DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gish and csnk-1

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_492694.1	Gene:	csnk-1 / 172891	WormBaseID:	WBGene00013709	Length:	407	Species:	Caenorhabditis elegans

Alignment Length:	438	Identity:	273/438 - (62%)
Similarity:	320/438 - (73%)	Gaps:	58/438 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MYSTRQSVSTTT-------GVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKA 99
            |.:||.|.|.|:       |||||||||:||||||||||||||||||||||||||||:|||||||
Worm     1 MTNTRGSNSATSASTTNSQGVLMVGPNFKVGKKIGCGNFGELRLGKNLYNNEHVAIKLEPMKSKA 65

  Fly   100 PQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTV 164
            ||||||||||||||.     .:|:|::::.|.| |:|||:|:||||.||||||::|.|.||||||
Worm    66 PQLHLEYRFYKLLGQ-----AEGLPQVHYFGPC-GKYNALVMELLGHSLEDLFDLCDRHFSLKTV 124

  Fly   165 LMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYR 229
            .|:|.||:.||||||::||||||||||||||||.||:::.::|||||||||||||.||.:||.||
Worm   125 AMVAMQLIRRIEYVHTKHLIYRDVKPENFLIGRYSTRKQHVLHIIDFGLAKEYIDCDTGKHIAYR 189

  Fly   230 EHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR 294
            |||||||||||||||||:|:|||||||||||||||||||||||||||||||||||||||||||||
Worm   190 EHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR 254

  Fly   295 ATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGK--TMS 357
            .|.:||||:|.|:|||.||||.|||||||||||||...||:.:.||.|.|.:.|||||.|  .:|
Worm   255 QTAVEVLCEGFPDEFAQYLRYARRLDFFETPDYDFCYNLFKSVLDRLGATYDYEFDWTPKLNNVS 319

  Fly   358 TPVGSLQTGHEVIISPNKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLTPADRH---GSVQVVS 419
            ||.|||.|      |.:||     .|...:|.:              .::.|..|   ||.||::
Worm   320 TPSGSLHT------SESKD-----VKRTDRGEL--------------KVSQAAAHAQFGSTQVIN 359

  Fly   420 STNGEL-----NPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKKK 462
            |..||:     |.:..||...|:.          .|.|||||.:|::|
Worm   360 SNAGEVVEESRNTEGRTAAGDNSS----------GEVKCCCFRRRRRK 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	226/292 (77%)
		S_TKc	62..335	CDD:214567	215/272 (79%)
		CK1gamma_C	354..428	CDD:289378	23/83 (28%)
csnk-1	NP_492694.1	STKc_CK1_gamma	27..314	CDD:271028	226/292 (77%)
csnk-1	NP_492694.1	SPS1	27..>249	CDD:223589	181/227 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	365	1.000	Domainoid score	I488
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I696
Isobase	1	0.950	-	0	Normalized mean entropy	S538
OMA	1	1.010	-	-		QHG52120
OrthoDB	1	1.010	-	-		D281034at33208
OrthoFinder	1	1.000	-	-		FOG0001189
OrthoInspector	1	1.000	-	-		oto20209
orthoMCL	1	0.900	-	-		OOG6_101750
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R203
SonicParanoid	1	1.000	-	-		X651
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.860