Protein Alignment gish and CSNK1E

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001885.1
• Gene: CSNK1E / 1454
• HGNCID: 2453
• Length: 416
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 198/416 - (47%)
• Similarity: 273/416 - (65%)
• Gaps: 45/416 - (10%)

  Fly    56 LMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 120
            |.||..:|:|:|||.|:||::.||.|:.:.|.||||:|.:|:|.||||:|.:|||::....
Human     3 LRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGV---- 63

  Fly   121 DGIPRIYHLGTCG--GRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHL 183
             |||.|   ..||  |.||.||:||||.|||||||.|:|||||||||::|.|::.||||:||::.
Human    64 -GIPSI---KWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNF 124

  Fly   184 IYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMG 248
            |:|||||:|||:|  ..|:..:::||||||||:|.|..|::||||||:|:|||||||.|||||:|
Human   125 IHRDVKPDNFLMG--LGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLG 187

  Fly   249 REQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYL 313
            .|||||||||:||::.|||..||||||||||.|.:::|::|.:.|.:|||||||.|:|.||:|||
Human   188 IEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYL 252

  Fly   314 RYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDWTGKTMSTPVGSLQTGHEVIISPNKDR- 377
            .:.|.|.|.:.|||.:||:||::||.|:|::.:..|||.    ....|:.:...:|    :::|
Human   253 NFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWN----MLKFGAARNPEDV----DRERR 309

  Fly   378 -HNVTAKTNAKGGVA--AWPDVPKPGATLGNL---------TPADR-----HGSVQVVSSTNGE- 424
             |....:.....|.|  |.|..|..|||...|         |||.|     :.|.:.:|..:.|
Human   310 EHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRER 374

  Fly   425 -----LNPDDPTAGHSNTPITQQPEV 445
                 |:...| |..|::.:|.:.||
Human   375 KVSMRLHRGAP-ANVSSSDLTGRQEV 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	168/294 (57%)
		CK1gamma_C	354..439	CDD:463640	24/108 (22%)
CSNK1E	NP_001885.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	164/283 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..416		26/104 (25%)