DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gish and ttbk1a

DIOPT Version :9

Sequence 1:	NP_001262624.1	Gene:	gish / 49701	FlyBaseID:	FBgn0250823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_009304405.1	Gene:	ttbk1a / 100332125	ZFINID:	ZDB-GENE-100609-4	Length:	1298	Species:	Danio rerio

Alignment Length:	511	Identity:	153/511 - (29%)
Similarity:	227/511 - (44%)	Gaps:	73/511 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AGNVANATTALAGGKSSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNE 86
            |..|.:....||.....:.||..|.:.........||...::|.||||.|.|||:....:|...|
Zfish    10 AARVLSGLQCLAPALQDNANMNGTAEQQDILPPHCMVKDRWKVLKKIGGGGFGEIYEALDLLTRE 74

  Fly    87 HVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCG--GRYNAMVLELLGLSLE 149
            :||:|:|..:.....|.:|....|.|        .|...:.....||  .::|.:|::|.|.:|.
Zfish    75 NVALKVESAQQPKQVLKMEVAVLKKL--------QGKNHVCKFIGCGRNDKFNYVVMQLQGRNLA 131

  Fly   150 DLFNICAR-KFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGR-TSTKREKIIHIIDFG 212
            ||.....| .|::.|.|.:.||:|..||.:||...::||:||.||.:|| .||.|:  .:::|||
Zfish   132 DLRRSQPRGTFTMSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTFRK--CYMLDFG 194

  Fly   213 LAKEYIDLDTNRHI-PYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQG 276
            ||::|  .:||..: |.|......||.||.|:|.|..:|..|.|||.:|.:|.:.|..|.|||:.
Zfish   195 LARQY--TNTNGEVRPPRTVAGFRGTVRYASVNAHKNKEMGRHDDLWSLFYMLVEFAAGQLPWRK 257

  Fly   277 LK----ADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDL 337
            :|    ...:||||..          .:|....|.||..:|.:|..||::..|||..|..:|::.
Zfish   258 IKDKEQVGQIKERYDH----------RMLLKHMPSEFNVFLEHVLALDYYTKPDYQLLMSVFENS 312

  Fly   338 FDRKGYTDEGEFDWTGKTMSTPVGSLQTGHEVIIS---PNKDRHNVTAKTNAKGGVAAWPDVPKP 399
            ...:..|:...:||.           ::|.|.|||   |...:.| |..|.|..||.....:|
Zfish   313 MKERIITENEPYDWE-----------KSGTETIISATTPTAAQQN-TRPTAAMVGVINVTPMP-- 363

  Fly   400 GATLGNLTPADRHGSVQVVSSTNGELNPDDPTAGHSNTPI--TQQP-EVEVVDETKCCCFFKRKK 461
                |:|...:....||....::.|..|..|    |..|:  :|.| :.:..:||.    |.|.|
Zfish   364 ----GDLPRENTDDVVQDEHLSDQENAPPIP----SGRPVDGSQMPTDADGWEETD----FNRNK 416

  Fly   462 ------KKSTRQKXLDGVQC--SPEREAVTLLRATSHSNSRDSVLNNPSQDYIQQA 509
                  |....:....|| |  ||:|..:.......|| .|...:|:|..|.:..|
Zfish   417 LRINLGKGGQEEDGSRGV-CPVSPQRGGLDSPGMQVHS-IRYRRVNSPESDRMSAA 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	101/301 (34%)
		S_TKc	62..335	CDD:214567	97/281 (35%)
		CK1gamma_C	354..428	CDD:289378	18/76 (24%)
ttbk1a	XP_009304405.1	PKc_like	49..310	CDD:304357	97/282 (34%)
ttbk1a	XP_009304405.1	Pkinase	50..295	CDD:278497	91/266 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810