Protein Alignment gish and ttbk1a

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: XP_009304405.1
• Gene: ttbk1a / 100332125
• ZFINID: ZDB-GENE-100609-4
• Length: 1298
• Species: Danio rerio
• Alignment Length: 511
• Identity: 153/511 - (29%)
• Similarity: 227/511 - (44%)
• Gaps: 73/511 - (14%)

  Fly    22 AGNVANATTALAGGKSSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNE 86
            |..|.:....||.....:.||..|.:.........||...::|.||||.|.|||:....:|...|
Zfish    10 AARVLSGLQCLAPALQDNANMNGTAEQQDILPPHCMVKDRWKVLKKIGGGGFGEIYEALDLLTRE 74

  Fly    87 HVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCG--GRYNAMVLELLGLSLE 149
            :||:|:|..:.....|.:|....|.|        .|...:.....||  .::|.:|::|.|.:|.
Zfish    75 NVALKVESAQQPKQVLKMEVAVLKKL--------QGKNHVCKFIGCGRNDKFNYVVMQLQGRNLA 131

  Fly   150 DLFNICAR-KFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGR-TSTKREKIIHIIDFG 212
            ||.....| .|::.|.|.:.||:|..||.:||...::||:||.||.:|| .||.|:  .:::|||
Zfish   132 DLRRSQPRGTFTMSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTFRK--CYMLDFG 194

  Fly   213 LAKEYIDLDTNRHI-PYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQG 276
            ||::|  .:||..: |.|......||.||.|:|.|..:|..|.|||.:|.:|.:.|..|.|||:.
Zfish   195 LARQY--TNTNGEVRPPRTVAGFRGTVRYASVNAHKNKEMGRHDDLWSLFYMLVEFAAGQLPWRK 257

  Fly   277 LK----ADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDL 337
            :|    ...:||||..          .:|....|.||..:|.:|..||::..|||..|..:|::.
Zfish   258 IKDKEQVGQIKERYDH----------RMLLKHMPSEFNVFLEHVLALDYYTKPDYQLLMSVFENS 312

  Fly   338 FDRKGYTDEGEFDWTGKTMSTPVGSLQTGHEVIIS---PNKDRHNVTAKTNAKGGVAAWPDVPKP 399
            ...:..|:...:||.           ::|.|.|||   |...:.| |..|.|..||.....:|
Zfish   313 MKERIITENEPYDWE-----------KSGTETIISATTPTAAQQN-TRPTAAMVGVINVTPMP-- 363

  Fly   400 GATLGNLTPADRHGSVQVVSSTNGELNPDDPTAGHSNTPI--TQQP-EVEVVDETKCCCFFKRKK 461
                |:|...:....||....::.|..|..|    |..|:  :|.| :.:..:||.    |.|.|
Zfish   364 ----GDLPRENTDDVVQDEHLSDQENAPPIP----SGRPVDGSQMPTDADGWEETD----FNRNK 416

  Fly   462 ------KKSTRQKXLDGVQC--SPEREAVTLLRATSHSNSRDSVLNNPSQDYIQQA 509
                  |....:....|| |  ||:|..:.......|| .|...:|:|..|.:..|
Zfish   417 LRINLGKGGQEEDGSRGV-CPVSPQRGGLDSPGMQVHS-IRYRRVNSPESDRMSAA 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	101/301 (34%)
		CK1gamma_C	354..439	CDD:463640	21/87 (24%)
ttbk1a	XP_009304405.1	Protein Kinases, catalytic domain	49..310	CDD:473864	97/282 (34%)