Protein Alignment gish and ttbk1b

DIOPT Version :10

• Sequence 1: NP_001262624.1
• Gene: gish / 49701
• FlyBaseID: FBgn0250823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: XP_021328804.1
• Gene: ttbk1b / 100000353
• ZFINID: ZDB-GENE-100609-5
• Length: 1219
• Species: Danio rerio
• Alignment Length: 538
• Identity: 150/538 - (27%)
• Similarity: 217/538 - (40%)
• Gaps: 117/538 - (21%)

  Fly    35 GKSSSNNMYSTRQSVSTTTGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKA 99
            |.....||....:.|.......:|...::|.||||.|.|||:....:|...|:||:|:|..:...
Zfish     7 GVHGDENMNGAGEQVDILPSNCLVKDRWKVLKKIGGGGFGEIYEAYDLLTRENVALKVESAQQPK 71

  Fly   100 PQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCG--GRYNAMVLELLGLSLEDLFNICAR-KFSL 161
            ..|.:|....|.|        .|...:.....||  .::|.:|::|.|.:|.||.....| .||:
Zfish    72 QVLKMEVAVLKKL--------QGKNHVCKFIGCGRNDKFNYVVMQLQGRNLADLRRSQPRGTFSM 128

  Fly   162 KTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGR-TSTKREKIIHIIDFGLAKEYIDLDTNRH 225
            .|.|.:.||:|..||.:||...::||:||.||.:|| .||.|:  .:::|||||::|  .:||..
Zfish   129 STTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTCRK--CYMLDFGLARQY--TNTNGE 189

  Fly   226 I-PYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLK----ADTLKER 285
            : |.|......||.||.|||.|..:|..|.|||.:|.:|.:.|..|.|||:.:|    ...:|||
Zfish   190 VRPPRSVAGFRGTVRYASINAHKNKEMGRHDDLWSLFYMLVEFTVGQLPWRKIKDKEQVGQIKER 254

  Fly   286 YQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFD 350
            |:.          .:|....|.||..:..:|..||:|..|||..|..:|::....:..|:...:|
Zfish   255 YEH----------RMLLKHMPAEFHIFYDHVLDLDYFTKPDYQLLMSVFENSMKDRVITENEPYD 309

  Fly   351 W--TGKTMSTPVGSLQTGHEVIISPNKDRHNVTAKTNAKGGVAAWPDVPKPGATLGNLTPA---- 409
            |  :|...:.|.           |.:......|.:|.|..||.             |:||.
Zfish   310 WEKSGTDTALPT-----------STHTPPQQNTRQTAAIVGVV-------------NVTPVPGEL 350

  Fly   410 ----------DRHGSVQVVSSTNGELNPDDPTAGHSNTPITQQPEVEVVDETKCCCFFKRKKKK- 463
                      |.|.|.|  .:....|.|..||     .|....|..|..|||.    |.|.:.:
Zfish   351 PRENTDDVLQDEHLSDQ--ENAPPALIPSRPT-----EPAPAAPAGEAWDETD----FNRNQLRI 404

  Fly   464 ---STRQKXLDG-------------------VQCSPER-------EAVTLLRATSHSN-----SR 494
               .|:....||                   .|..|.|       |:..|..|....:     ||
Zfish   405 SISKTQVAAEDGDEPAGGGRSVSPARGGEGDAQARPPRYRRVNSPESERLSGAEDRGDGADKRSR 469

  Fly   495 DSVLNNPSQDYIQQATSQ 512
            ..:|.:||:.......:|
Zfish   470 LDMLGSPSRHVYSSQPAQ 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gish	NP_001262624.1	STKc_CK1_gamma	61..354	CDD:271028	103/303 (34%)
		CK1gamma_C	354..439	CDD:463640	18/98 (18%)
ttbk1b	XP_021328804.1	Protein Kinases, catalytic domain	33..294	CDD:473864	99/282 (35%)