Protein Alignment OGDH and kgd1

DIOPT Version :10

• Sequence 1: NP_001425936.1
• Gene: OGDH / 4967
• HGNCID: 8124
• Length: 1038
• Species: Homo sapiens
• Sequence 2: NP_595772.1
• Gene: kgd1 / 2540991
• PomBaseID: SPBC3H7.03C
• Length: 1009
• Species: Schizosaccharomyces pombe
• Alignment Length: 1038
• Identity: 474/1038 - (45%)
• Similarity: 653/1038 - (62%)
• Gaps: 55/1038 - (5%)

Human     8 AAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSV 72
            :||.|.|..| .|..:..||.....:.||.|.: |....:.||:|.:::||:|||.||.::|.||
pombe     8 SAKARALRRS-AVTAYRLNRLTCLSSLQQNRTF-ATQPTDDFLTGGAADYVDEMYDAWKKDPNSV 70

Human    73 HKSWDIFFRNT-NAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRA 136
            |.||..:|:|. ..|..|..|:|:| ||...:.:..|...||:......|..|..::.||.|:||
pombe    71 HASWQAYFKNVQERGVSPSKAFQAP-PLLDYADSYTALDSSLINGNNYADIDVGIYMKVQLLVRA 134

Human   137 YQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLDLAVFKERLRMLTVGGFYGLDESDLDKVF 201
            ||.||||:|:||||||   :::.:.|:::...                    .||..||||::..
pombe   135 YQSRGHHLAKLDPLGI---NVNHNRPSELTLE--------------------HYGFTESDLNRTI 176

Human   202 HLP---TTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTN 263
            ||.   ...|.......:.||||:...|..||....|||..|:..::..||....|||...::::
pombe   177 HLGPGILPNFREAGRKTMTLREIVETCEKIYCGSFAVEFTHISSRKRSNWILSHLETPTPFRYSH 241

Human   264 EEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRG 328
            ::|..:..||..:..||.||..|:.::|||||||||.::|.:|.:||:|.:.|:..:::||.|||
pombe   242 DQKIMIFDRLSWADSFERFLFTKFPNDKRFGLEGCEAMVPGMKALIDRSVDEGISNIVIGMAHRG 306

Human   329 RLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLE 393
            |||:|.|::||..:.||.:|....:..|||||||||||||.::| ...:.:.::|||||||||||
pombe   307 RLNLLHNIVRKPAQAIFSEFRGTQDPDDEGSGDVKYHLGMNYQR-PTPSGKRVSLSLVANPSHLE 370

Human   394 AADPVVMGKTKAEQFYCGD-TEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVV 457
            |.||||:||.:|.|.|..| ...::.|.||:|||||||.||:|||||.|..||.|:|.||||:|:
pombe   371 AEDPVVLGKVRAIQHYTSDEASHEQSMGILIHGDAAFAAQGVVYETFGLHALPGYSTGGTVHIVI 435

Human   458 NNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVC 522
            |||||||||||.|||:||.||:|:.:.|||||||.||.|||.::|::||:||..|..|||||:||
pombe   436 NNQIGFTTDPRFARSTPYCTDIAKSMEAPIFHVNGDDVEAVTFICQLAADWRKAFKTDVVVDIVC 500

Human   523 YRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFAR 587
            |||:||||.|:|.||||.|||.|.|..|..:.|.:.|:.:..|::.|.:.:..:...|.|.:|..
pombe   501 YRRHGHNETDQPSFTQPRMYKAIAKHPPTFKIYTQQLLQEKTVSKAEVDAQEKRVWDILESSFES 565

Human   588 SKDEKILHIKHWLDSPWPGFFTLDGQPRSMS---CPS--TGLTEDILTHIGNVASSVPVENFTIH 647
            ||:.|..| :.||.:||.||    ..|:.:.   .||  ||:..|.|..||....::| |.|..|
pombe   566 SKNYKSDH-REWLSNPWVGF----ASPKDLMTKILPSYPTGVNIDTLKQIGKALYTLP-EGFDAH 624

Human   648 GGLSRILKTRGEMVKN-RTVDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVD 711
            ..|.|||..|.:.:.: ..:|...||.:|||:||:||.|:|:|||||||||||.||.|||||: .
pombe   625 RNLKRILNNRNKSISSGEGIDMPTAEALAFGTLLEEGHHVRVSGQDVERGTFSQRHAVLHDQS-S 688

Human   712 KRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQF 776
            :...||:|||.||||.:.:.|||||||||||||.|::::||||||:||||||||.|.||||||||
pombe   689 ENVYIPLNHLSPNQASFVIRNSSLSEYGVLGFEYGYSLSSPNALVVWEAQFGDFANNAQCIIDQF 753

Human   777 ICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCN 841
            |..|:.||:::.||||.||||.:|.||||||||.||:||:||:||...|..::..   .|..|||
pombe   754 IAAGETKWLQRTGIVLSLPHGYDGQGPEHSSARMERYLQLCNEDPREFPSEEKLQ---RQHQDCN 815

Human   842 WVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPED--G 904
            ...:..:.|..:||.|||.|...|||||:||..|||||||.|||:.||......|:.::.|:  |
pombe   816 IQAIYVTKPSQYFHALRRNIHRQFRKPLVIFFSKSLLRHPAARSTIDEFDEKHGFKLILEEEEHG 880

Human   905 PAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPN-AEL 968
            .:...||.:::|:.|:|:|:..|::.|: .:.:..:||||:|||.||.:..:...:.:||| .|:
pombe   881 KSILPPEKIEKLIICSGQVWVALSKARE-ENKIDNIAITRVEQLHPFGWKQMAANISQYPNLKEI 944

Human   969 AWCQEEHKNQGYYDYVKPRLRTT---ISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTA 1028
            .|||||..|.|.:.|::||:.|.   :.|..||.||||.|:|:.|.|||:.||.|.::.|:.|
pombe   945 IWCQEEPLNAGAWTYMEPRIYTILKHLGRDLPVRYAGRPPSASVAAGNKQQHLAEQEQFLNDA 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OGDH	NP_001425936.1	None
kgd1	NP_595772.1	SucA	47..1008	CDD:440333	462/997 (46%)