Protein Alignment OGDH and ogdh-1

DIOPT Version :10

• Sequence 1: NP_001425936.1
• Gene: OGDH / 4967
• HGNCID: 8124
• Length: 1038
• Species: Homo sapiens
• Sequence 2: NP_500617.1
• Gene: ogdh-1 / 177235
• WormBaseID: WBGene00020679
• Length: 1029
• Species: Caenorhabditis elegans
• Alignment Length: 1030
• Identity: 582/1030 - (56%)
• Similarity: 752/1030 - (73%)
• Gaps: 55/1030 - (5%)

Human    30 AARTFQQIRCYS--APVAAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTA 92
            :|.|..|.|..|  |.|..||||:|:||.|:|:||.|||::|.|||.|||.:|||..|||.||.|
 Worm    30 SASTLVQHRNQSVAAAVKHEPFLNGSSSIYIEQMYEAWLQDPSSVHTSWDAYFRNVEAGAGPGQA 94

Human    93 YQSPLPLS--RGSL-AAVAHAQSLVEAQP--NVD-----KLVEDHLAVQSLIRAYQIRGHHVAQL 147
            :|:| |.:  .|:| .:.|.||....:.|  .:|     :.:.|||.:|.|||:||.|||::|.|
 Worm    95 FQAP-PATAYAGALGVSPAAAQVTTSSAPATRLDTNASVQSISDHLKIQLLIRSYQTRGHNIADL 158

Human   148 DPLGILDADLDSSVPADIISSTDKLDLAVFKERLRMLTVGGFYGLDESDLDKVFHLPTTTFIGGQ 212
            |||||..||||.::|.:       |:|:             ||||.|.|||:.|.||.|||| .:
 Worm   159 DPLGINSADLDDTIPPE-------LELS-------------FYGLGERDLDREFLLPPTTFI-SE 202

Human   213 ESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRST 277
            :.:|.||||::||:..||...|||:|.:|:|||..|||::||.|.:.:.::::|:.|..||:|||
 Worm   203 KKSLTLREILQRLKDIYCTSTGVEYMHLNNLEQQDWIRRRFEAPRVTELSHDQKKVLFKRLIRST 267

Human   278 RFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELE 342
            :|||||.:||.||||||||||||||||:|.:||.||..|||..::||||||||||||||.|:.|.
 Worm   268 KFEEFLAKKWPSEKRFGLEGCEVLIPAMKQVIDSSSTLGVDSFVIGMPHRGRLNVLANVCRQPLA 332

Human   343 QIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQ 407
            .|..|| |.||.|||||||||||||:...|:||.:.:|:.:::|||||||||.|||||||.:||.
 Worm   333 TILSQF-STLEPADEGSGDVKYHLGVCIERLNRQSQKNVKIAVVANPSHLEAVDPVVMGKVRAEA 396

Human   408 FYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARS 472
            ||.||.:..:.|:|||||||||||||:|.|||:|.|||||||||.:|:|||||||||||||.:||
 Worm   397 FYAGDEKCDRTMAILLHGDAAFAGQGVVLETFNLDDLPSYTTHGAIHIVVNNQIGFTTDPRSSRS 461

Human   473 SPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFT 537
            |||.|||.|||..||||||.|||||||:||.|||:||.||.|||:||||||||:||||:||||||
 Worm   462 SPYCTDVGRVVGCPIFHVNVDDPEAVMHVCNVAADWRKTFKKDVIVDLVCYRRHGHNELDEPMFT 526

Human   538 QPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKH--WL 600
            |||||::|::.|..|:||.|.::::||.|:...:||::||..|.|:|:..:  :|:.::::  ||
 Worm   527 QPLMYQRIKQTKTALEKYQEKILNEGVANEQYVKEELTKYGSILEDAYENA--QKVTYVRNRDWL 589

Human   601 DSPWPGFFTLDGQPRSMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRT 665
            ||||..||.   :...:..||||:.::.:..|....|..| |.|.:|.||.|.||.|.:|:|:.:
 Worm   590 DSPWDDFFK---KRDPLKLPSTGIEQENIEQIIGKFSQYP-EGFNLHRGLERTLKGRQQMLKDNS 650

Human   666 VDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTV 730
            :|||..|.:|||||||||||:|||||||:||||||||||||||.||::...|:|.|...|..|||
 Worm   651 LDWACGEALAFGSLLKEGIHVRLSGQDVQRGTFSHRHHVLHDQKVDQKIYNPLNDLSEGQGEYTV 715

Human   731 CNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP 795
            ||||||||.|||||||::|..||:||:||||||||.|||||||||||..||:||:||:|:|:|||
 Worm   716 CNSSLSEYAVLGFELGYSMVDPNSLVIWEAQFGDFSNTAQCIIDQFISSGQSKWIRQSGLVMLLP 780

Human   796 HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLK----EANFDINQLYDCNWVVVNCSTPGNFFHV 856
            ||.||||||||||||||||||||:|.::  ||:    |..|:..||:|.||:|.||:||.|.:|:
 Worm   781 HGYEGMGPEHSSARPERFLQMCNEDDEI--DLEKIAFEGTFEAQQLHDTNWIVANCTTPANIYHL 843

Human   857 LRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTG 921
            ||||:.:|||||.::|:||||||||.|||..::...|::|||||||.|..:|||.:|||::||||
 Worm   844 LRRQVTMPFRKPAVVFSPKSLLRHPMARSPVEDFQSGSNFQRVIPETGAPSQNPPDVKRVVFCTG 908

Human   922 KVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYYDYVKP 986
            |||||:...||.......||:.|:|||||||:||:.:|.:||..||:.|.||||||.|.:.:|:|
 Worm   909 KVYYDMVAARKHVGKENDVALVRVEQLSPFPYDLVQQECRKYQGAEILWAQEEHKNMGAWSFVQP 973

Human   987 RLRTTIS-RAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAF-----DLDVFK 1035
            |:.:.:| ..:...||||.|:::||||||.||:.|.:.::...|     .|:.||
 Worm   974 RINSLLSIDGRATKYAGRLPSSSPATGNKFTHMQEQKEMMSKVFGVPKSKLEGFK 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OGDH	NP_001425936.1	None
ogdh-1	NP_500617.1	SucA	51..1019	CDD:440333	570/998 (57%)