DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hrg and PAP1

DIOPT Version :9

Sequence 1:	NP_001261097.1	Gene:	hrg / 49636	FlyBaseID:	FBgn0015949	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_012927.3	Gene:	PAP1 / 853871	SGDID:	S000001710	Length:	568	Species:	Saccharomyces cerevisiae

Alignment Length:	571	Identity:	223/571 - (39%)
Similarity:	326/571 - (57%)	Gaps:	57/571 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVS 90
            |..|:|..:|.......:.:..|.|...|:....||::.|..:|:::|..|..|.:::|.|:|..
Yeast     5 KVFGITGPVSTVGATAAENKLNDSLIQELKKEGSFETEQETANRVQVLKILQELAQRFVYEVSKK 69

  Fly    91 KNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECR 155
            |||.:..|...||||:|:||||||||..|:|||.|.|.|:::.|.|:|..|..:|:::.|:.|..
Yeast    70 KNMSDGMARDAGGKIFTYGSYRLGVHGPGSDIDTLVVVPKHVTREDFFTVFDSLLRERKELDEIA 134

  Fly   156 SVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILA 220
            .|.:||||:||:.|.||.|||:.|||...::|....|.|.|||||||.:.:|:|||.|||||||.
Yeast   135 PVPDAFVPIIKIKFSGISIDLICARLDQPQVPLSLTLSDKNLLRNLDEKDLRALNGTRVTDEILE 199

  Fly   221 LVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFLVFS 285
            |||....||:|||.|||||::..:|:|..|:.|||.|||||||.|||||||.:|.::::||::.|
Yeast   200 LVPKPNVFRIALRAIKLWAQRRAVYANIFGFPGGVAWAMLVARICQLYPNACSAVILNRFFIILS 264

  Fly   286 RWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTKKVILTEFN 350
            .|.||.||:||..::..|:.:||:|::.|.||.|.||:||||||...:|.|::||||||||.||.
Yeast   265 EWNWPQPVILKPIEDGPLQVRVWNPKIYAQDRSHRMPVITPAYPSMCATHNITESTKKVILQEFV 329

  Fly   351 RGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADD-HLEWCGLVESKVRLLIGNLE 414
            ||:.||::|...:..|..|||...||:||:.::.:...::.:|: ||:|.||||||||||:..||
Yeast   330 RGVQITNDIFSNKKSWANLFEKNDFFFRYKFYLEITAYTRGSDEQHLKWSGLVESKVRLLVMKLE 394

  Fly   415 RNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQG----------------------NQ 457
            ....|.:||...|.||         |......|||.:..|.                      .:
Yeast   395 VLAGIKIAHPFTKPFE---------SSYCCPTEDDYEMIQDKYGSHKTETALNALKLVTDENKEE 450

  Fly   458 SAVTSAP--FCSMWFIGLEF-----ERSENLNVDLTESI---QNFTEHVMMHGV-NI-------- 503
            .::..||  :.|..:|||:|     :...::::..||.:   ::|.|....|.| |:
Yeast   451 ESIKDAPKAYLSTMYIGLDFNIENKKEKVDIHIPCTEFVNLCRSFNEDYGDHKVFNLALRFVKGY 515

  Fly   504 ----KMLKEGMTIDARHVKRKQLSLYLDSDFLKRERKSMESHNNFNNTLLA 550
                ::..|.....::..|||.|....::  :||.:....|.:|.|.|..|
Yeast   516 DLPDEVFDENEKRPSKKSKRKNLDARHET--VKRSKSDAASGDNINGTTAA 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PTZ00418	28..600	CDD:240410	222/569 (39%)
		PAP_central	29..371	CDD:282745	163/341 (48%)
		PAP_RNA-bind	374..534	CDD:282743	51/205 (25%)
PAP1	NP_012927.3	PAP1	1..555	CDD:227513	218/560 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346545
Domainoid	1	1.000	342	1.000	Domainoid score	I153
eggNOG	1	0.900	-	-		E1_COG5186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56959
Inparanoid	1	1.050	391	1.000	Inparanoid score	I326
Isobase	1	0.950	-	0	Normalized mean entropy	S941
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001429
OrthoInspector	1	1.000	-	-		oto99288
orthoMCL	1	0.900	-	-		OOG6_100691
Panther	1	1.100	-	-	LDO	PTHR10682
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3127
SonicParanoid	1	1.000	-	-		X722
TreeFam	1	0.960	-	-
	15	14.730