Protein Alignment hrg and PAPOLG

DIOPT Version :10

• Sequence 1: NP_001261097.1
• Gene: hrg / 49636
• FlyBaseID: FBgn0015949
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_075045.2
• Gene: PAPOLG / 64895
• HGNCID: 14982
• Length: 736
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 344/680 - (50%)
• Similarity: 440/680 - (64%)
• Gaps: 91/680 - (13%)

  Fly    26 KQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVS 90
            |..|:||.||||.|:..|...|.:|..:::|:.|||.::|||||:.:|.|||.|||:|:.::|.|
Human    17 KHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDVSES 81

  Fly    91 KNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECR 155
            ||:|.|....:||||:||||||||||.|||||||||||||::||:|:||||||.||.|..:...|
Human    82 KNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGIRNLR 146

  Fly   156 SVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILA 220
            :||:|||||||..||||||||:||||:::.|.|:.|||||:.||:||.|.:|||||||||||||.
Human   147 AVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILH 211

  Fly   221 LVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFLVFS 285
            ||||.|.|||.||.:|||||:.|||||.||:.|||:|||||||||||||||||:|||||||||||
Human   212 LVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFS 276

  Fly   286 RWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTKKVILTEFN 350
            :|:||||||||.|:..||...|||||||.||||||||||||||||||||:|||.||:.|::.||.
Human   277 KWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFK 341

  Fly   351 RGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVESKVRLLIGNLER 415
            :|:.:||||:.|:..|.:|.|.|:||.:|||:|||..::.|.::||||.||||||:|:|:|||||
Human   342 QGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLER 406

  Fly   416 NPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSMWFIGLEFERSEN 480
            |..|.||||||:.|   .|...::..||                     :.||||:|:.|.|.||
Human   407 NEFITLAHVNPQSF---PGNKEHHKDNN---------------------YVSMWFLGIIFRRVEN 447

  Fly   481 ---LNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYLDSDFLKRERKSMESHN 542
               :|:|||..||:||:.|.....||.||||||.|:|.|||:|||..||.::.|::::|...|.
Human   448 AESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQSLSD- 511

  Fly   543 NFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEENSNASSDMGAGT 607
                   .||                    |||      |.:.:||  ||.....::|.|...||
Human   512 -------VNR--------------------SSG------GLQSKRL--SLDSSCLDSSRDTDNGT 541

  Fly   608 PTTPTTAQLSAPSFKSSGKNGSE--IDVVEQEPTQPHNNG------NASSNTTTTEVACSXQPPT 664
            |.....::..:||...:.:|.:|  ..:||:..:.|...|      .|..::|...|:    |||
Human   542 PFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVS----PPT 602

  Fly   665 LHPHP-------------PHQQPPPAPPQP 681
            :...|             ||.   ||..||
Human   603 VCTIPTVVGRNVIPRITTPHN---PAQGQP 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PAP_central	29..371	CDD:461486	228/341 (67%)
		PAP_RNA-bind	374..534	CDD:461484	75/162 (46%)
PAPOLG	NP_075045.2	PAP_central	20..363	CDD:461486	228/342 (67%)
		PAP_RNA-bind	366..503	CDD:461484	75/160 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..564		20/93 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..720