DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hrg and PAPOLB

DIOPT Version :9

Sequence 1:	NP_001261097.1	Gene:	hrg / 49636	FlyBaseID:	FBgn0015949	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_064529.4	Gene:	PAPOLB / 56903	HGNCID:	15970	Length:	637	Species:	Homo sapiens

Alignment Length:	754	Identity:	344/754 - (45%)
Similarity:	448/754 - (59%)	Gaps:	140/754 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STSG----GPPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNT 78
            :|.|    .||..:.|::|.||||.|:..|...|..|..:|.|:.|||.::||..|:.:|.|||.
Human     7 TTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQRRILVLEKLNN 71

  Fly    79 LVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFE 143
            |||:|::|||.||::|:|..|.:||||:||||||||||.||||||||||||.:::|:|:|.||:.
Human    72 LVKEWIREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPSHVDRSDFFTSFYA 136

  Fly   144 VLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRS 208
            .||.|.||.:.|:||||||||||:.|||||||:|||||:|:.||:|.|||||:||:|||.|.:||
Human   137 KLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRS 201

  Fly   209 LNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAA 273
            |||||||||||.|||||:||||.||.||||||.|.||||.||:.|||:|||||||||||||||.|
Human   202 LNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKCHNIYSNILGFLGGVSWAMLVARTCQLYPNAVA 266

  Fly   274 ATLVHKFFLVFSRWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVS 338
            :|||.|||||||.|:||||||||.|:..||...|||||||.||||||||||||||||||||:|||
Human   267 STLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVS 331

  Fly   339 ESTKKVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVE 403
            .||:.|::.||.:|:.||.||:|.:..|.:||||||||.:|:|:||||.::.|...||||.||||
Human   332 ISTRMVMIEEFKQGLAITHEILLSKAEWSKLFEAPSFFQKYKHYIVLLASASTEKQHLEWVGLVE 396

  Fly   404 SKVRLLIGNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSM 468
            ||:|:|:|:||:|..|.||||||:.|...|            ...|:::            |.:|
Human   397 SKIRILVGSLEKNEFITLAHVNPQSFPAPK------------ENPDMEE------------FRTM 437

  Fly   469 WFIGLEFERSEN---LNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYLDSDF 530
            |.|||..::.:|   |::|||..||:||:.|....||.||.:.||.|.|.|::||:|
Human   438 WVIGLGLKKPDNSEILSIDLTYDIQSFTDTVYRQAVNSKMFEMGMKITAMHLRRKEL-------- 494

  Fly   531 LKRERKSMESHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEE 595
                      |....:.:|.::|..|||                       |.::..|:||
Human   495 ----------HQLLPHHVLQDKKAHSTE-----------------------GRRLTDLNDS---- 522

  Fly   596 NSNASSDMGAG------TPTTPTTAQLSAPSFKSSGKNGSEIDVVEQEPTQPHNNGNAS-SNTTT 653
                |.|:.||      .|::.:|.:.......|.|:|...:.|:           .|| :|...
Human   523 ----SFDLSAGCENSMSVPSSTSTMKTGPLISSSQGRNSPALAVM-----------TASVANIQA 572

  Fly   654 TEVACSXQPPTLHPHPPHQQPPPAPPQPPAHHHHHQKFRKNNNAAAAAASNSIFNQRSILHAASS 718
            ||.:..                                :.|.|.::..|.|     .||.||.|
Human   573 TEFSLQ--------------------------------QVNTNESSGVALN-----ESIPHAVS- 599

  Fly   719 LSAALSITGHKRKQQTATSTTMISSSNIAHSNYTQHSTH 757
             ..|:|.:......:..:||.:||..::..   ||..|:
Human   600 -QPAISPSPKAMVARVVSSTCLISHPDLQE---TQQQTY 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PTZ00418	28..600	CDD:240410	307/574 (53%)
		PAP_central	29..371	CDD:282745	229/341 (67%)
		PAP_RNA-bind	374..534	CDD:282743	64/162 (40%)
PAPOLB	NP_064529.4	PTZ00418	21..569	CDD:240410	319/631 (51%)
		PAP_central	22..364	CDD:282745	229/341 (67%)
		PAP_RNA-bind	367..496	CDD:282743	64/170 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146151
Domainoid	1	1.000	500	1.000	Domainoid score	I348
eggNOG	1	0.900	-	-		E1_COG5186
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I814
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48793
OrthoDB	1	1.010	-	-		D252593at33208
OrthoFinder	1	1.000	-	-		FOG0001429
OrthoInspector	1	1.000	-	-		otm40821
orthoMCL	1	0.900	-	-		OOG6_100691
Panther	1	1.100	-	-	O	PTHR10682
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X722
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770