DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hrg and papola

DIOPT Version :9

Sequence 1:	NP_001261097.1	Gene:	hrg / 49636	FlyBaseID:	FBgn0015949	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	XP_005160406.1	Gene:	papola / 404041	ZFINID:	ZDB-GENE-030131-3507	Length:	724	Species:	Danio rerio

Alignment Length:	670	Identity:	343/670 - (51%)
Similarity:	436/670 - (65%)	Gaps:	81/670 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEI 87
            |..|..|:||.||||.|:..||..|.:|..:|.|:.|||.:.||..|:.:|.|||||||.|::|:
Zfish    14 PTPKHYGITSPISLAPPKEADLVLTRKLTETLRPFGVFEEELELQRRILVLGKLNTLVKFWIREV 78

  Fly    88 SVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVT 152
            |.:||:|.|..:.:||||:||||||||||.|||||||||||||::||||:|.||:|.||:|.||.
Zfish    79 SEAKNIPASVIDSVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERTDFFSSFYEKLKEQEEVK 143

  Fly   153 ECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDE 217
            :.|:||||||||||:.|||||||:|||||:|:.||::.|||||.||:|||.|.:|||||||||||
Zfish   144 DLRAVEEAFVPVIKLAFDGIEIDILFARLALQTIPENLDLRDDGLLKNLDIRCIRSLNGCRVTDE 208

  Fly   218 ILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFL 282
            ||.||||||||||.||.||||||:|.||||.||:.|||:|||||||||||||||.||||||||||
Zfish   209 ILHLVPNIENFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAVAATLVHKFFL 273

  Fly   283 VFSRWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTKKVILT 347
            |||:|:||||||||.|::.||...||||||..||||||||||||||||||||:|||.||:.:::.
Zfish   274 VFSKWEWPNPVLLKQPEDCNLNLPVWDPRVTPSDRYHLMPIITPAYPQQNSTYNVSASTRAIMVE 338

  Fly   348 EFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVESKVRLLIGN 412
            ||.||:.|||||:..:..|.:|||||:||.:|:|:||||.::||...||||.||||||:|:|:||
Zfish   339 EFKRGLAITDEILQNKADWSKLFEAPNFFQKYKHYIVLLASAQTEKQHLEWVGLVESKIRILVGN 403

  Fly   413 LERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSMWFIGLEF-- 475
            ||:|..|.||||||:.|...|          .||:.:              .|.:||.||:.|
Zfish   404 LEKNEFITLAHVNPQSFPGPK----------EGNDKE--------------EFSTMWVIGIVFKK 444

  Fly   476 -ERSENLNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYLDSDFLKRERKSME 539
             |.|||||||||..||:||:.|....:..||.::.|.|.|.|||||||...|....:.|.::
Zfish   445 MEGSENLNVDLTFDIQSFTDTVYRQAITSKMFEQDMKITAMHVKRKQLHQLLPEVAIHRSKR--- 506

  Fly   540 SHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEENSNASSDMG 604
                                                   :.|...::.::||..:.:.::.:.|.
Zfish   507 ---------------------------------------KHSSDGVRAMNDSNLDLSLDSDNSMS 532

  Fly   605 AGTPTTPTTAQLS-APSFKSS---GKNGSEIDVVEQEPTQPHN-----NGNASSNTTTTEVA--C 658
            ..:||.|:.|::: |||.:.|   ..|.||:. .:.|.|..:.     :|.:|||.:....|  .
Zfish   533 VPSPTGPSAAKIARAPSPQGSTGTATNTSELQ-GKTEATGENTHLASVDGTSSSNASGKGAAPPQ 596

  Fly   659 SXQPPTLHPHPPHQQPPPAP 678
            | .|......|..|.|.|:|
Zfish   597 STSPIQSEKKPSEQNPLPSP 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PTZ00418	28..600	CDD:240410	315/574 (55%)
		PAP_central	29..371	CDD:282745	235/341 (69%)
		PAP_RNA-bind	374..534	CDD:282743	72/162 (44%)
papola	XP_005160406.1	PTZ00418	7..561	CDD:240410	327/612 (53%)
		PAP_central	20..362	CDD:282745	235/341 (69%)
		PAP_RNA-bind	365..494	CDD:282743	71/152 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579718
Domainoid	1	1.000	504	1.000	Domainoid score	I326
eggNOG	1	0.900	-	-		E1_COG5186
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	671	1.000	Inparanoid score	I713
OMA	1	1.010	-	-		QHG48793
OrthoDB	1	1.010	-	-		D252593at33208
OrthoFinder	1	1.000	-	-		FOG0001429
OrthoInspector	1	1.000	-	-		otm24757
orthoMCL	1	0.900	-	-		OOG6_100691
Panther	1	1.100	-	-	O	PTHR10682
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X722
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770