DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hrg and papolg

DIOPT Version :9

Sequence 1:	NP_001261097.1	Gene:	hrg / 49636	FlyBaseID:	FBgn0015949	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_956915.1	Gene:	papolg / 393593	ZFINID:	ZDB-GENE-040426-1256	Length:	744	Species:	Danio rerio

Alignment Length:	850	Identity:	388/850 - (45%)
Similarity:	500/850 - (58%)	Gaps:	164/850 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GNSTSGG-PPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTL 79
            ||||.|| .|.|..|:||:||||.||..|...|.:|..:::|:.|||.:||||||:.:|.|||:.
Zfish     8 GNSTLGGQQPRKHYGITSSISLAFPREIDHIYTQKLTEAMKPFGVFEGEDELNHRLAVLGKLNSF 72

  Fly    80 VKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEV 144
            ||:|:.|||.|||:|.||...:||||:||||||||||.|||||||||||||::||||:|.||||.
Zfish    73 VKEWISEISESKNLPPSAVANVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERTDFFSSFFEK 137

  Fly   145 LKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSL 209
            ||:..|:.:.|:||:|||||||..|||||||||||||:|:.|||:.|||.|:||||||.|.:|||
Zfish   138 LKRHDEIKDLRAVEDAFVPVIKFKFDGIEIDLLFARLALQSIPDNLDLRGDSLLRNLDIRCIRSL 202

  Fly   210 NGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAA 274
            ||||||||||.||||.|||||.||.||||||:.|||||.||:.|||:|||||||||||||||.||
Zfish   203 NGCRVTDEILYLVPNKENFRLTLRAIKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAVAA 267

  Fly   275 TLVHKFFLVFSRWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSE 339
            |||||||||||:|:||||||||.|::.||...|||||||.||||||||||||||||||||:|||.
Zfish   268 TLVHKFFLVFSKWEWPNPVLLKQPEDSNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVST 332

  Fly   340 STKKVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVES 404
            ||:.::..||..|:.:||||:.|:..|.:|||.|:||.:|||:|||..::.|.::||||.|||||
Zfish   333 STRTIMNEEFKNGLTVTDEILQGKADWSKLFEPPNFFQQYRHYIVLTASASTEENHLEWIGLVES 397

  Fly   405 KVRLLIGNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSMW 469
            |:|:|:||||||.:|.||||||:.|   .|...|.::|:                     |.|||
Zfish   398 KIRVLVGNLERNEYITLAHVNPQSF---PGSKENRNEND---------------------FVSMW 438

  Fly   470 FIGLEFERSEN---LNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYLDSDFL 531
            |||:.|::.:|   :|:|||..||:||:.|.....||.|||:||||:|.|||:|||..||..:.:
Zfish   439 FIGISFKKLDNSDCVNIDLTYDIQSFTDTVYRQASNINMLKDGMTIEATHVKKKQLHHYLPPELV 503

  Fly   532 KRERKSMESHNNFNNTLLANRKRL-STELAQSQD-----------PLPPGQQPSSGNRGRDSGAK 584
            :|::||:...|..:|...:.|..| |::|..|:|           |:....||:|
Zfish   504 QRKKKSLGDINRSSNGGGSKRCSLDSSQLDSSRDTDIGTPFSSPTPISKPCQPAS---------- 558

  Fly   585 IQRLSDSLTEENSNASSDMGAGTPT-----TPTTAQLSAPSFKSSGKNGSEIDVVEQEPTQPHNN 644
                    |.|::::|...   .|.     :|..::||.|    ..:.|..|.|:..:|
Zfish   559 --------TPEDNSSSPPQ---HPVLVFMDSPPASELSQP----KPEQGMSIPVIGSKP------ 602

  Fly   645 GNASSNTTTTEVACSXQPPTLHPHPPHQQPPPAPPQPPAHHHHHQKFRKNNNAAAAAASNSIFNQ 709
                   .||.||                   .||.|||           .|........|:..:
Zfish   603 -------ITTPVA-------------------KPPTPPA-----------GNTIPTVVGRSVIPR 630

  Fly   710 RSILHAASSLSAALSITGHKRKQQTAT---------STTMISSSNIAHSNYTQHSTHNNNGGGGG 765
            .    ||||...|.|:.|..::..:.:         .|.:.|..:.....|...|    ||
Zfish   631 L----AASSPELANSVNGAPKRPHSPSLEDPPKRHKDTEVFSDDSAFKEPYPPSS----NG---- 683

  Fly   766 SHYNKTYYIDDDD--------EDNNQPLLTPNNQTQQQQKAVRITATSASPATSVPVAASAAPPA 822
                    :|.|:        |....|:  |...|.:.|:.         |:..:|.|:|   |.
Zfish   684 --------LDGDEGQTVEALAETKAMPI--PTIDTSRSQRL---------PSKELPDASS---PI 726

  Fly   823 PTISL 827
            ||.:|
Zfish   727 PTSNL 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PTZ00418	28..600	CDD:240410	331/586 (56%)
		PAP_central	29..371	CDD:282745	237/341 (70%)
		PAP_RNA-bind	374..534	CDD:282743	74/162 (46%)
papolg	NP_956915.1	PTZ00418	9..566	CDD:240410	338/598 (57%)
		PAP_central	22..365	CDD:282745	238/342 (70%)
		PAP_RNA-bind	367..506	CDD:282743	74/162 (46%)
		K1377	<543..>620	CDD:291997	26/144 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	504	1.000	Domainoid score	I326
eggNOG	1	0.900	-	-		E1_COG5186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56959
Inparanoid	1	1.050	671	1.000	Inparanoid score	I713
OMA	1	1.010	-	-		QHG48793
OrthoDB	1	1.010	-	-		D252593at33208
OrthoFinder	1	1.000	-	-		FOG0001429
OrthoInspector	1	1.000	-	-		otm24757
orthoMCL	1	0.900	-	-		OOG6_100691
Panther	1	1.100	-	-	LDO	PTHR10682
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3127
SonicParanoid	1	1.000	-	-		X722
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870