Protein Alignment hrg and pla1

DIOPT Version :10

• Sequence 1: NP_001261097.1
• Gene: hrg / 49636
• FlyBaseID: FBgn0015949
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_595362.1
• Gene: pla1 / 2541099
• PomBaseID: SPBC646.04
• Length: 566
• Species: Schizosaccharomyces pombe
• Alignment Length: 578
• Identity: 213/578 - (36%)
• Similarity: 328/578 - (56%)
• Gaps: 60/578 - (10%)

  Fly    26 KQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVS 90
            ||.|:|..||.|....::......|...|:..|:|||..|...|:::|.:|..:..::||::|::
pombe     4 KQWGITPPISTAPATEQENALNTALINELKNQNLFESPAESEKRVKVLDELQQITTEFVKKVSLA 68

  Fly    91 KNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECR 155
            |:|.|..|.:.||||:|:|||||||:..|:|||.|.|.|:::.|.::||....:|:::.|||:..
pombe    69 KHMNEKMANEAGGKIFTYGSYRLGVYGPGSDIDTLVVVPKHVSRDNFFQDLEPMLREREEVTDLA 133

  Fly   156 SVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILA 220
            :|.:|:||:||..|.||.|||:|||||:..:|.|.:|.|:|||:.::.|.|.||||.||||:||.
pombe   134 AVPDAYVPIIKFKFLGISIDLIFARLSVPRVPRDLELSDNNLLKGVEERCVLSLNGTRVTDQILQ 198

  Fly   221 LVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFLVFS 285
            ||||...|:.|||.||.||::..||:|.:|:.|||.|||:|||.|||||||.::.:|.|||.:..
pombe   199 LVPNRAVFKHALRAIKFWAQRRAIYANVVGFPGGVAWAMMVARICQLYPNAVSSVIVAKFFRILH 263

  Fly   286 RWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTKKVILTEFN 350
            :|.||.|:|||..::..|:.::|:|::..||:.|.|||||||||...:|.|::.||:.:||.|..
pombe   264 QWNWPQPILLKPIEDGPLQVRIWNPKLYPSDKAHRMPIITPAYPSMCATHNITLSTQTIILREMV 328

  Fly   351 RGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVESKVRLLIGNLER 415
            |...|.|:||:..:||..||:...||:||:|::.:...::||:..|:|.||||||:|.|:..||.
pombe   329 RAGEIADQIMVKALPWSALFQKHDFFHRYKHYLTITAAAKTAEAQLKWAGLVESKLRHLVTRLEL 393

  Fly   416 NPHIALAHVNPKCFEFKKG--------------------------------QSANNSQNNSGNED 448
            ...|||||      .|.||                                :.||::.|....::
pombe   394 VDAIALAH------PFNKGFDKVYNCSSEEEAQQVASGVTLEVAYESTDHEKLANDTVNEEKADN 452

  Fly   449 DLKQSQGNQSAVTS--APFCSMWFIGLEFERSEN---LNVDLTESIQNFTEHVMMHGVNIKMLKE 508
            ...::.|:::....  ..:.:..:||||.|:.:.   ..:|::...|.|.|      :..|..|.
pombe   453 TESKADGSENGEKQIFPVYTTTCYIGLELEKKKGHPIKRLDISWPTQEFYE------LCKKWDKY 511

  Fly   509 GMTIDARHVKRKQLSLYLDSDFLKRERKSMESHNNFNNTLLANRKRLSTELAQSQDPL 566
            ..|:....:|..:.:...|..|...|.:..           |.:||.:.:.|.|.:.|
pombe   512 DDTLMNVFIKNTKNTALPDEVFEPGEERPK-----------ATKKRSTADTAHSTEQL 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PAP_central	29..371	CDD:461486	157/341 (46%)
		PAP_RNA-bind	374..534	CDD:461484	46/196 (23%)
pla1	NP_595362.1	PAP_central	7..350	CDD:461486	158/342 (46%)
		PAP_RNA-bind	352..540	CDD:461484	47/199 (24%)