Protein Alignment hrg and Papola

DIOPT Version :10

• Sequence 1: NP_001261097.1
• Gene: hrg / 49636
• FlyBaseID: FBgn0015949
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_006515659.1
• Gene: Papola / 18789
• MGIID: 109301
• Length: 753
• Species: Mus musculus
• Alignment Length: 832
• Identity: 374/832 - (44%)
• Similarity: 487/832 - (58%)
• Gaps: 141/832 - (16%)

  Fly    15 NGNSTSGG-----PPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILA 74
            :|..|:.|     ||.:..|:||.||||.|:..|...|.:|..:|:|:.|||.::||..|:.||.
Mouse    16 SGPVTTQGSQQTQPPQRHYGITSPISLAAPKETDCLLTQKLIETLKPFGVFEEEEELQRRILILG 80

  Fly    75 KLNTLVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQ 139
            |||.|||:|::|||.|||:|:|..|.:||||:||||||||||.|||||||||||||:::|:|:|.
Mouse    81 KLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFT 145

  Fly   140 SFFEVLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHR 204
            ||::.||.|.||.:.|:||||||||||:.|||||||:|||||:|:.||:|.|||||:||:|||.|
Mouse   146 SFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIR 210

  Fly   205 SVRSLNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYP 269
            .:|||||||||||||.|||||:||||.||.||||||:|.||||.||:.|||:|||||||||||||
Mouse   211 CIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYP 275

  Fly   270 NAAAATLVHKFFLVFSRWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNST 334
            ||.|:|||||||||||:|:||||||||.|:..||...|||||||.||||||||||||||||||||
Mouse   276 NAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNST 340

  Fly   335 FNVSESTKKVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWC 399
            :|||.||:.|::.||.:|:.|||||:|.:..|.:|||||:||.:|:|:||||.::.|....|||.
Mouse   341 YNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWV 405

  Fly   400 GLVESKVRLLIGNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAP 464
            ||||||:|:|:|:||:|..|.||||||:.|...| :|.:..:
Mouse   406 GLVESKIRILVGSLEKNEFITLAHVNPQSFPAPK-ESPDREE----------------------- 446

  Fly   465 FCSMWFIGLEF---ERSENLNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYL 526
            |.:||.|||.|   |.||||:||||..||:||:.|....:|.||.:..|.|.|.|||||||...|
Mouse   447 FRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFELDMKIAAMHVKRKQLHQLL 511

  Fly   527 DSDFLKRERKSMESHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDS 591
            .|..|::                  ||:.|||                       |.|:..|:||
Mouse   512 PSHVLQK------------------RKKHSTE-----------------------GVKLTALNDS 535

  Fly   592 LTEENSNASSDMGAGTPTTPTTAQLSAP---SFKSSGKN--------GSEIDVVEQEPTQPHNNG 645
            ..:.:.::.:.|..   .:||:|..::|   |..|.|:|        .|...:...|.:.|..|.
Mouse   536 SLDLSMDSDNSMSV---PSPTSAMKTSPLNSSGSSQGRNSPAPAVTAASVTSIQASEVSVPQANS 597

  Fly   646 NASSNTTTTEVACSXQPPTLHPHPPHQQPPPAPPQPPAHHHHHQKFRKNNNAAAAAASNSIFNQR 710
            :.|....::|    ..|.|.      .||..:||..|             ..:...:|..:.|..
Mouse   598 SESPGGPSSE----SIPQTA------TQPAISPPPKP-------------TVSRVVSSTRLVNPS 639

  Fly   711 SILHAASSLSAALSITGHKRKQQTATSTTMISSSNIAHSNYTQHSTHNNNGGGGGSHYNKTYYID 775
            ......::......|.|.||          .||.|...|.                  .||...:
Mouse   640 PRPSGNTATKVPNPIVGVKR----------TSSPNKEESP------------------KKTKTEE 676

  Fly   776 DD-DEDNNQPLLTPNNQTQQQQKAVRITATSASPATSVPVAASAAPPAPTIS 826
            |: .||.|...|:.:::|:.:::.  ...|||..:.:||.:||......|.|
Mouse   677 DETSEDANCLALSGHDKTETKEQV--DLETSAVQSETVPASASLLASQKTSS 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PAP_central	29..371	CDD:461486	235/341 (69%)
		PAP_RNA-bind	374..534	CDD:461484	71/162 (44%)
Papola	XP_006515659.1	PAP_central	35..377	CDD:461486	235/341 (69%)
		PAP_RNA-bind	381..509	CDD:461484	68/151 (45%)
		Herpes_BLLF1	<544..>739	CDD:282904	49/239 (21%)