DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hrg and pap-1

DIOPT Version :9

Sequence 1:	NP_001261097.1	Gene:	hrg / 49636	FlyBaseID:	FBgn0015949	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_001379022.1	Gene:	pap-1 / 179458	WormBaseID:	WBGene00012528	Length:	655	Species:	Caenorhabditis elegans

Alignment Length:	725	Identity:	278/725 - (38%)
Similarity:	399/725 - (55%)	Gaps:	97/725 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVSKN 92
            ||::..||||.|..:|:.:|..|..:|:.:..:|.::|...|||:|..||.|||:|||.::..|
Worm    12 LGVSQPISLAHPDSKDIAQTTLLIETLKKFGSYEPKEETEQRMEVLRNLNRLVKEWVKNVTAMK- 75

  Fly    93 MPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECRSV 157
            :|.......|||::||||||||||..|||||.|.|.||:|:|:|:|.||.|:|...|.|||...|
Worm    76 IPNGEGVNAGGKLFTFGSYRLGVHSSGADIDTLAVVPRHIDRSDFFTSFKEMLNNDPNVTELHGV 140

  Fly   158 EEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILALV 222
            |||||||:|:.:.|:|:|:|||||:|||:||..:|.|||||||||..||||||||||.:::|.||
Worm   141 EEAFVPVMKLKYSGVELDILFARLALKEVPDTQELSDDNLLRNLDQESVRSLNGCRVAEQLLKLV 205

  Fly   223 PNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFLVFSRW 287
            |..:.|.:.||.||||||.|||||||:|:|||:|||:||||.|||||||:.:.|||:.|.:||.|
Worm   206 PRQKEFCVTLRAIKLWAKNHGIYSNSMGFFGGITWAILVARACQLYPNASPSRLVHRMFFIFSTW 270

  Fly   288 KWPNPVLLKHPDN-----VNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTKKVILT 347
            .||:||:|...:|     ..|...|||||...:||:|:|||||||:|:||||.||:.||..||..
Worm   271 TWPHPVVLNEMNNDRNDIPTLCELVWDPRRKNTDRFHVMPIITPAFPEQNSTHNVTRSTATVIKN 335

  Fly   348 EFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVESKVRLLIGN 412
            |....:.|..:|..|:..|..|||..:||.||:|||.|::.:...::.|.:.|.:||::|||:.:
Worm   336 EICEALEICRDISEGKSKWTALFEEVNFFSRYKHFIALIMAAPNEEEELNYGGFLESRIRLLVQS 400

  Fly   413 LERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSMWFIGLEF-E 476
            ||||..|.:||.:|     .|.:.:.|::.:...|:         ..||      :||||||| |
Worm   401 LERNQDIIIAHNDP-----NKHKPSPNAKFDVNPEN---------KRVT------VWFIGLEFAE 445

  Fly   477 RSENLNVDLTESIQNFTEHVMMHGVNIKMLKEG--MTIDARHVKRKQLSLYLDSDFLKRERKSME 539
            .::.|  |||..||.|..:|.:...|:|.:...  :.||..:|||..|...:.:..|:|.|:..:
Worm   446 HAKTL--DLTNEIQRFKTNVELQASNVKGIGPNCQVQIDMFYVKRNSLIQVISAADLRRGRRWKK 508

  Fly   540 SHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEENSNASSDMG 604
            ......||.:::    ||              |.|..|              .|..:|..::..|
Worm   509 VVPIATNTSVSS----ST--------------PRSVVR--------------TTSTSSVPTTPTG 541

  Fly   605 AGTPTTPTTAQLSAPSFKSSGKNGSEIDVVEQEPTQPHNNGNASSNTTTTEVACSXQPPTLHPHP 669
            ...|.||.:|.:||.:...|..||:.:       ::..:....||.|.|:::
Worm   542 LAAPKTPLSASVSATNEPDSTTNGTPL-------SRKRSMDEESSTTVTSQI------------- 586

  Fly   670 PHQQPPPAPPQPPAHHHHHQKFRKNNNAAAAAASNSIFNQRS-------ILHAASSLSAALSITG 727
                   :....|..........:|..:.....||.:..||:       .|.|.:.|:.:..:..
Worm   587 -------SDESVPKKKTRDDTLEENRVSMVVEVSNVVVEQRTKVVQEIVDLQADNGLNTSNGLEA 644

  Fly   728 HKRKQQTATS 737
            .::|.:...|
Worm   645 SEQKMEVPQS 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PTZ00418	28..600	CDD:240410	253/579 (44%)
		PAP_central	29..371	CDD:282745	186/346 (54%)
		PAP_RNA-bind	374..534	CDD:282743	53/162 (33%)
pap-1	NP_001379022.1	PAP_central	13..360	CDD:398542	187/347 (54%)
pap-1	NP_001379022.1	PAP_RNA-bind	362..>461	CDD:398540	43/120 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167326
Domainoid	1	1.000	388	1.000	Domainoid score	I413
eggNOG	1	0.900	-	-		E1_COG5186
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I855
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48793
OrthoDB	1	1.010	-	-		D252593at33208
OrthoFinder	1	1.000	-	-		FOG0001429
OrthoInspector	1	1.000	-	-		otm14136
orthoMCL	1	0.900	-	-		OOG6_100691
Panther	1	1.100	-	-	LDO	PTHR10682
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X722
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810