Protein Alignment hrg and pap-1

DIOPT Version :10

• Sequence 1: NP_001261097.1
• Gene: hrg / 49636
• FlyBaseID: FBgn0015949
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001379022.1
• Gene: pap-1 / 179458
• WormBaseID: WBGene00012528
• Length: 655
• Species: Caenorhabditis elegans
• Alignment Length: 725
• Identity: 278/725 - (38%)
• Similarity: 399/725 - (55%)
• Gaps: 97/725 - (13%)

  Fly    28 LGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVSKN 92
            ||::..||||.|..:|:.:|..|..:|:.:..:|.::|...|||:|..||.|||:|||.::..|
 Worm    12 LGVSQPISLAHPDSKDIAQTTLLIETLKKFGSYEPKEETEQRMEVLRNLNRLVKEWVKNVTAMK- 75

  Fly    93 MPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECRSV 157
            :|.......|||::||||||||||..|||||.|.|.||:|:|:|:|.||.|:|...|.|||...|
 Worm    76 IPNGEGVNAGGKLFTFGSYRLGVHSSGADIDTLAVVPRHIDRSDFFTSFKEMLNNDPNVTELHGV 140

  Fly   158 EEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILALV 222
            |||||||:|:.:.|:|:|:|||||:|||:||..:|.|||||||||..||||||||||.:::|.||
 Worm   141 EEAFVPVMKLKYSGVELDILFARLALKEVPDTQELSDDNLLRNLDQESVRSLNGCRVAEQLLKLV 205

  Fly   223 PNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFLVFSRW 287
            |..:.|.:.||.||||||.|||||||:|:|||:|||:||||.|||||||:.:.|||:.|.:||.|
 Worm   206 PRQKEFCVTLRAIKLWAKNHGIYSNSMGFFGGITWAILVARACQLYPNASPSRLVHRMFFIFSTW 270

  Fly   288 KWPNPVLLKHPDN-----VNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTKKVILT 347
            .||:||:|...:|     ..|...|||||...:||:|:|||||||:|:||||.||:.||..||..
 Worm   271 TWPHPVVLNEMNNDRNDIPTLCELVWDPRRKNTDRFHVMPIITPAFPEQNSTHNVTRSTATVIKN 335

  Fly   348 EFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVESKVRLLIGN 412
            |....:.|..:|..|:..|..|||..:||.||:|||.|::.:...::.|.:.|.:||::|||:.:
 Worm   336 EICEALEICRDISEGKSKWTALFEEVNFFSRYKHFIALIMAAPNEEEELNYGGFLESRIRLLVQS 400

  Fly   413 LERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSMWFIGLEF-E 476
            ||||..|.:||.:|     .|.:.:.|::.:...|:         ..||      :||||||| |
 Worm   401 LERNQDIIIAHNDP-----NKHKPSPNAKFDVNPEN---------KRVT------VWFIGLEFAE 445

  Fly   477 RSENLNVDLTESIQNFTEHVMMHGVNIKMLKEG--MTIDARHVKRKQLSLYLDSDFLKRERKSME 539
            .::.|  |||..||.|..:|.:...|:|.:...  :.||..:|||..|...:.:..|:|.|:..:
 Worm   446 HAKTL--DLTNEIQRFKTNVELQASNVKGIGPNCQVQIDMFYVKRNSLIQVISAADLRRGRRWKK 508

  Fly   540 SHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEENSNASSDMG 604
            ......||.:::    ||              |.|..|              .|..:|..::..|
 Worm   509 VVPIATNTSVSS----ST--------------PRSVVR--------------TTSTSSVPTTPTG 541

  Fly   605 AGTPTTPTTAQLSAPSFKSSGKNGSEIDVVEQEPTQPHNNGNASSNTTTTEVACSXQPPTLHPHP 669
            ...|.||.:|.:||.:...|..||:.:       ::..:....||.|.|:::
 Worm   542 LAAPKTPLSASVSATNEPDSTTNGTPL-------SRKRSMDEESSTTVTSQI------------- 586

  Fly   670 PHQQPPPAPPQPPAHHHHHQKFRKNNNAAAAAASNSIFNQRS-------ILHAASSLSAALSITG 727
                   :....|..........:|..:.....||.:..||:       .|.|.:.|:.:..:..
 Worm   587 -------SDESVPKKKTRDDTLEENRVSMVVEVSNVVVEQRTKVVQEIVDLQADNGLNTSNGLEA 644

  Fly   728 HKRKQQTATS 737
            .::|.:...|
 Worm   645 SEQKMEVPQS 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PAP_central	29..371	CDD:461486	186/346 (54%)
		PAP_RNA-bind	374..534	CDD:461484	53/162 (33%)
pap-1	NP_001379022.1	PAP_central	13..360	CDD:461486	187/347 (54%)
		PAP_RNA-bind	363..>461	CDD:461484	43/119 (36%)