DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hrg and pap-3

DIOPT Version :9

Sequence 1:	NP_001261097.1	Gene:	hrg / 49636	FlyBaseID:	FBgn0015949	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_496524.1	Gene:	pap-3 / 174816	WormBaseID:	WBGene00009658	Length:	554	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	253/550 - (46%)
Similarity:	338/550 - (61%)	Gaps:	48/550 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEI 87
            |..:..|::..||.|.|..:||:.|..|:.:|..||.:|.|:|.:.|:::|.|||..||||:::|
Worm    14 PITRTFGVSQPISTALPNAKDLELTSSLQKTLNQYNSYEPQEETSQRVKVLQKLNGCVKQWIQKI 78

  Fly    88 SVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVT 152
            :.:: .|:......||::..|||||||||..|||||.|.:|||:..|.|:|.||.::|.|.||||
Worm    79 TEAR-YPKDQLFNAGGQLMAFGSYRLGVHSSGADIDTLVLAPRHATRADFFSSFKQMLAKDPEVT 142

  Fly   153 ECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDE 217
            ...:||.||||::.|.:.|||||.|||||:|||:|:|.|:.||.||:|||..||||||||||.:.
Worm   143 NLCAVENAFVPIMTMKYSGIEIDFLFARLALKEVPEDLDILDDALLKNLDQESVRSLNGCRVAEN 207

  Fly   218 ILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAAATLVHKFFL 282
            :|.||||.|||.:.||.||||||.|||||||:|:|||:|||:||||.|||||||:.:.|:.|.|.
Worm   208 LLKLVPNQENFCITLRAIKLWAKNHGIYSNSMGFFGGITWAILVARACQLYPNASPSKLIQKVFF 272

  Fly   283 VFSRWKWPNPVLL-----KHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVSESTK 342
            :||.||||.||||     ...|...|...|||||.|.|||||||||:|||:||||||.|||.|:.
Worm   273 IFSTWKWPAPVLLDFISSDRMDLAQLNQLVWDPRRNQSDRYHLMPIVTPAFPQQNSTHNVSRSSM 337

  Fly   343 KVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVESKVR 407
            |||..|....:...|.|..|...|..|.|..:||.||:|||.|.:.::|..|.|.:.|..||::|
Worm   338 KVIQEEMKDALITCDNIQNGSCNWMDLLEEINFFSRYKHFISLSMTAETEKDELAFGGFFESRIR 402

  Fly   408 LLIGNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSMWFIG 472
            .|:..||:|..|.|||:|||.|:..|.                             |..|:||||
Worm   403 QLVLILEKNQGIKLAHINPKKFKAAKD-----------------------------PKKSVWFIG 438

  Fly   473 LEFERSENL-NVDLTESIQNFTEHVMMHGVNIKMLKEGMTI--DARHVKRKQLSLYLDSDFLKRE 534
            |:|:  ||: |:|||:.||.|..::.....::|.::....:  |..:|||..|:..:....||:.
Worm   439 LQFD--ENVKNLDLTKDIQQFKRNIDYQAKSVKDIEANCAVETDFSYVKRSDLAQTISVKDLKQG 501

  Fly   535 R--KSMESHNNFNNTLLANRKRLSTELAQS 562
            :  |..||.:.      .::||..:|.|.|
Worm   502 KMYKKPESKDP------VSKKRKVSENAPS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PTZ00418	28..600	CDD:240410	251/544 (46%)
		PAP_central	29..371	CDD:282745	190/346 (55%)
		PAP_RNA-bind	374..534	CDD:282743	53/162 (33%)
pap-3	NP_496524.1	PAP_central	20..366	CDD:368197	190/346 (55%)
pap-3	NP_496524.1	PAP_RNA-bind	369..489	CDD:368195	50/150 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167328
Domainoid	1	1.000	388	1.000	Domainoid score	I413
eggNOG	1	0.900	-	-		E1_COG5186
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I855
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48793
OrthoDB	1	1.010	-	-		D252593at33208
OrthoFinder	1	1.000	-	-		FOG0001429
OrthoInspector	1	1.000	-	-		otm14136
orthoMCL	1	0.900	-	-		OOG6_100691
Panther	1	1.100	-	-	O	PTHR10682
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3127
SonicParanoid	1	1.000	-	-		X722
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800