Protein Alignment hrg and pap-2

DIOPT Version :9

• Sequence 1: NP_001261097.1
• Gene: hrg / 49636
• FlyBaseID: FBgn0015949
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_496067.1
• Gene: pap-2 / 174513
• WormBaseID: WBGene00011791
• Length: 554
• Species: Caenorhabditis elegans
• Alignment Length: 517
• Identity: 238/517 - (46%)
• Similarity: 329/517 - (63%)
• Gaps: 41/517 - (7%)

  Fly    13 QHNGNSTSGGPPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLN 77
            |...|:||..|   ..|::..||.|.|:..|:..|..|:.|||.:..|||:.|...|:::|..|:
 Worm     2 QSVNNATSSTP---IFGVSQPISTAFPKANDVALTSSLQSSLEEFKSFESKQETLLRIKVLKNLD 63

  Fly    78 TLVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFF 142
            .|||.||::.::|: :|:......|||:..|||||||||..|||||::.||||:|.|:|:|.||.
 Worm    64 GLVKDWVQKTTISR-IPKDQMFNAGGKLIPFGSYRLGVHSSGADIDSIVVAPRHITRSDFFNSFK 127

  Fly   143 EVLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVR 207
            ::|.|.|||||..:||:||||::.:.:.|::||:|||||:||.:|:|.::.||:||:|||..|||
 Worm   128 DILAKNPEVTELCAVEKAFVPIMTLKYSGVDIDILFARLALKSVPEDLNILDDSLLKNLDEESVR 192

  Fly   208 SLNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAA 272
            |||||||.:::|.|||:.:||.:.||.||||||.|||||||:|:|||:|||:||||.||||||||
 Worm   193 SLNGCRVAEQLLKLVPHQKNFCITLRAIKLWAKNHGIYSNSMGFFGGITWAILVARICQLYPNAA 257

  Fly   273 AATLVHKFFLVFSRWKWPNPVLLKH-----PDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQN 332
            .:.|:.|.|.:||.|.||.||||.:     .|...|...|||||.|.:||||||||||||:||||
 Worm   258 PSRLIQKVFFIFSTWNWPAPVLLDYINCDRTDLAQLNQLVWDPRRNHADRYHLMPIITPAFPQQN 322

  Fly   333 STFNVSESTKKVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLE 397
            ||.|||.|:.|||..|..:.:.|.|:|..|.:.|..|.|..:||.:|.|||.|.:.:::..:.|.
 Worm   323 STHNVSRSSMKVIQDEMKKALIICDKIHEGTLEWRDLLEEINFFSKYHHFIALKLKAESVKEELA 387

  Fly   398 WCGLVESKVRLLIGNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTS 462
            :.|..||::|.|:..||:|..|.:|.:||:.|:                  |:|.
 Worm   388 FGGFFESRIRQLVQILEKNQVIQVAQINPRKFK------------------DVKD---------- 424

  Fly   463 APFCSMWFIGLEFERSENLNVDLTESIQNFTEHVMMHGVNIKMLKEGMTI--DARHVKRKQL 522
             |..|:|||||||..:.. |||||..||.|..::....:::|.:..|..:  |..:.||..|
 Worm   425 -PKKSIWFIGLEFVANVK-NVDLTSDIQQFKMNIDRQSMSVKEIAAGCQVETDFTYEKRSNL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrg	NP_001261097.1	PTZ00418	28..600	CDD:240410	233/502 (46%)
		PAP_central	29..371	CDD:282745	186/346 (54%)
		PAP_RNA-bind	374..534	CDD:282743	46/151 (30%)
pap-2	NP_496067.1	PAP_central	15..361	CDD:368197	186/346 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167327
Domainoid	1	1.000	388	1.000	Domainoid score	I413
eggNOG	1	0.900	-	-		E1_COG5186
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I855
Isobase	1	0.950	-	0	Normalized mean entropy	S941
OMA	1	1.010	-	-		QHG48793
OrthoDB	1	1.010	-	-		D252593at33208
OrthoFinder	1	1.000	-	-		FOG0001429
OrthoInspector	1	1.000	-	-		otm14136
orthoMCL	1	0.900	-	-		OOG6_100691
Panther	1	1.100	-	-	O	PTHR10682
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3127
SonicParanoid	1	1.000	-	-		X722
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750