DRSC/TRiP Functional Genomics Resources

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Protein Alignment hrg and PAPOLA

DIOPT Version :10

Sequence 1:NP_001261097.1 Gene:hrg / 49636 FlyBaseID:FBgn0015949 Length:827 Species:Drosophila melanogaster
Sequence 2:NP_116021.2 Gene:PAPOLA / 10914 HGNCID:14981 Length:745 Species:Homo sapiens


Alignment Length:839 Identity:382/839 - (45%)
Similarity:491/839 - (58%) Gaps:140/839 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 STSGG----PPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNT 78
            :|.|.    ||.|..|:||.||||.|:..|...|.:|..:|:|:.|||.::||..|:.||.|||.
Human     6 TTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQRRILILGKLNN 70

  Fly    79 LVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFE 143
            |||:|::|||.|||:|:|..|.:||||:||||||||||.|||||||||||||:::|:|:|.||::
Human    71 LVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYD 135

  Fly   144 VLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRS 208
            .||.|.||.:.|:||||||||||:.|||||||:|||||:|:.||:|.|||||:||:|||.|.:||
Human   136 KLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRS 200

  Fly   209 LNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAA 273
            |||||||||||.|||||:||||.||.||||||:|.||||.||:.|||:|||||||||||||||.|
Human   201 LNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIA 265

  Fly   274 ATLVHKFFLVFSRWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVS 338
            :|||||||||||:|:||||||||.|:..||...|||||||.||||||||||||||||||||:|||
Human   266 STLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVS 330

  Fly   339 ESTKKVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVE 403
            .||:.|::.||.:|:.|||||:|.:..|.:|||||:||.:|:|:||||.::.|....|||.||||
Human   331 VSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVE 395

  Fly   404 SKVRLLIGNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSM 468
            ||:|:|:|:||:|..|.||||||:.|...|        .|...|:                |.:|
Human   396 SKIRILVGSLEKNEFITLAHVNPQSFPAPK--------ENPDKEE----------------FRTM 436

  Fly   469 WFIGLEF---ERSENLNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYLDSDF 530
            |.|||.|   |.||||:||||..||:||:.|....:|.||.:..|.|.|.|||||||        
Human   437 WVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQL-------- 493

  Fly   531 LKRERKSMESHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEE 595
                      |....|.:|..:|:.|||                       |.|:..|:||..:.
Human   494 ----------HQLLPNHVLQKKKKHSTE-----------------------GVKLTALNDSSLDL 525

  Fly   596 NSNASSDMGAGTPTTPTTAQLSAPSFKSSGKN--------GSEIDVVEQEPTQPHNNGNASSNTT 652
            :.::.:.|...:||:.|.......|..|.|:|        .|..::...|.:.|..|.:.||..|
Human   526 SMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGT 590

  Fly   653 TTEVACSXQPPTLHPHPPHQQPPPAPPQPPAHHHHHQKFRKNNNAAAAAASNSIFN--QRSILHA 715
            ::|     .|.|.      .||..:||..|             ..:...:|..:.|  .||..:|
Human   591 SSE----SIPQTA------TQPAISPPPKP-------------TVSRVVSSTRLVNPPPRSSGNA 632

  Fly   716 ASSLSAALS----ITGHKR-----KQQTATSTTMISSSNIAHSNYTQHSTHNNNGGGGGSHYNKT 771
            |:|.:||..    |.|.||     |:::...|..........:|....|.|              
Human   633 ATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGH-------------- 683

  Fly   772 YYIDDDDEDNNQPLLTPNNQTQQQ--QKAVRITA---TSASPATSVPVAASAAPPAPTI 825
                 |..:..:.|.|..:.||.:  |.|..:.|   ||::..:.:|  |..|.|.|.|
Human   684 -----DKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTDLSDIP--ALPANPIPVI 735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hrgNP_001261097.1 PAP_central 29..371 CDD:461486 235/341 (69%)
PAP_RNA-bind 374..534 CDD:461484 69/162 (43%)
PAPOLANP_116021.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 5/15 (33%)
PAP_central 21..363 CDD:461486 235/341 (69%)
PAP_RNA-bind 367..495 CDD:461484 69/169 (41%)
Nuclear localization signal 1. /evidence=ECO:0000250 490..507 7/34 (21%)
motB <501..646 CDD:183756 42/190 (22%)
Ser/Thr-rich 508..643 40/180 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..565 8/41 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..704 36/168 (21%)
Nuclear localization signal 2. /evidence=ECO:0000250 650..665 3/14 (21%)
Required for interaction with NUDT21 677..745 18/80 (23%)

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