Protein Alignment Invadolysin and Lmln

DIOPT Version :9

• Sequence 1: NP_652072.1
• Gene: Invadolysin / 49580
• FlyBaseID: FBgn0086359
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_766411.1
• Gene: Lmln / 239833
• MGIID: 2444736
• Length: 681
• Species: Mus musculus
• Alignment Length: 691
• Identity: 296/691 - (42%)
• Similarity: 387/691 - (56%)
• Gaps: 65/691 - (9%)

  Fly    21 GICSW----LLV--------------SATAHNCQHQHPKAHEVVHGVRIQLADSEDDSAGDPARH 67
            |.|.|    |||              ..|:..|:|......||::.|.::            ..|
Mouse    21 GGCLWVRGVLLVLGGLPAGAGAAPVSLGTSPPCRHHVLSDTEVINKVHLK------------TNH 73

  Fly    68 SVRRRSVAAEQPLRILLVYDESVYRLEEEKFNLINDTVLPEAVQFWEQALMVRETKGVIRLNRKC 132
            ..:|   .|:..|||..:||:|:..|..||..|:.:.:.|:|:.:.|:...||...|.|.|:|:|
Mouse    74 VTKR---DADGHLRIKTIYDQSIEELLPEKRYLVKNKLFPQAISYLEKTFQVRRPAGRILLSRQC 135

  Fly   133 DSTQVYVKNG--HTHCIDHCKATTMCGEVQVPDAHLDVCRVCNATGQNCRIDSNTQPGEGIENAD 195
            .:.|...|..  |.:|...|...|.||.|.||:.||..||||......|.......| ||:.:||
Mouse   136 ATNQYLRKENDPHRYCTGECAVHTKCGPVIVPEEHLQQCRVCREGKWPCGAVGVLDP-EGVRDAD 199

  Fly   196 FVFYVSARQTQRCFKGLTVAYAAHCQQEAALDRPIAGHANLCPESISTKPQELQTLISTVKHEIL 260
            ||.||.|..|:||.....::|||:|||||.:||||||:|||||..|||:|||...::|||||||:
Mouse   200 FVLYVGALATERCSHENIISYAAYCQQEAKMDRPIAGYANLCPNMISTQPQEFIGMLSTVKHEII 264

  Fly   261 HALGFSVSLYAFFRDDDGKPRTPRKLDTGKPYLNEKLQIHQWSNETIRKVVRENWSVRGGHVNKV 325
            ||||||..|:||:.|.||.|.|.|..| |.|..|..|.::|||::.:|||.| .|:||.   ||:
Mouse   265 HALGFSAGLFAFYHDQDGNPLTSRSAD-GLPPFNYSLGLYQWSDKVVRKVER-LWNVRD---NKI 324

  Fly   326 VD----MMVTPRVIAEVRAHFNCNKLEGAELEDQGGEGTALTHWEKRILENEAMTGTHTQSPVFS 386
            |.    ::|||||:.|.|.||||..|||.|||:|||.||.|.|||||:||||||||:|||:.|.|
Mouse   325 VRHTVYLLVTPRVVEEARKHFNCPVLEGMELENQGGMGTELNHWEKRLLENEAMTGSHTQNRVLS 389

  Fly   387 RITLALMEDSGWYRANYSMATPLTWGKGLGCAFAMRSCKDWIQYNHARGRSIHPFCSKVKQDPLQ 451
            |||||||||:|||:||||||..|.||:||||.|..:|||.||..:..|.:...|:|..::.:|||
Mouse   390 RITLALMEDTGWYKANYSMAEKLDWGRGLGCEFVRKSCKFWIDQHRQRRQVPSPYCDTLRSNPLQ 454

  Fly   452 TECTDDRNSVALCNLIRHEFELPKGYQNFDSLNHVKDGEEGFYGGSVSLADHCPYIQEFTWRSKN 516
            ..|..|:.:||:|||.|....||..||.||.|..:...:..:|||||.:||:||:.|||:|....
Mouse   455 LTCRQDQRAVAVCNLQRFPNPLPPEYQYFDELTGIPAEDLPYYGGSVEIADYCPFSQEFSWHLSG 519

  Fly   517 VIVRGSHCRFTENNPRPEKNFALESYGEGAKCFDHSESMWEERSCHQTREWQHWGSGCYKYDCFD 581
            ...|.|.||..||.|...||:..|.||..:.|.....:...|: |.:...:..||||||:..|..
Mouse   520 EYQRSSDCRILENQPELFKNYGAEQYGPHSVCLLQKSAFIMEQ-CERKLSYPDWGSGCYQVSCSP 583

  Fly   582 GRLHILVGNYSYKCSFPGQKLSIRIAANGWLHKGAIMCPPCHELCGAQFAAQGKQCRPGEEPDPL 646
            ..|.:.|.:.||.||..||.|.:||..|||:|.|.::||.|.:.|        :||.|..:|...
Mouse   584 QGLKVWVQDTSYLCSRAGQVLPVRIQMNGWIHNGNLLCPSCWDFC--------EQCPPETDPPAA 640

  Fly   647 N---KYPRDNLACGAGSEKSRSVAIITAVLL--LFGLRWGF 682
            |   ..|.|..:|      |.|:.:...:||  ||.|..||
Mouse   641 NLTRALPLDLCSC------SSSLVVTLWLLLGNLFPLLAGF 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Invadolysin	NP_652072.1	Peptidase_M8	93..628	CDD:302875	258/540 (48%)
Lmln	NP_766411.1	Peptidase_M8	96..628	CDD:302875	257/538 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850272
Domainoid	1	1.000	335	1.000	Domainoid score	I1126
eggNOG	1	0.900	-	-		E1_KOG2556
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13198
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1192
Isobase	1	0.950	-	0	Normalized mean entropy	S3900
OMA	1	1.010	-	-		QHG48900
OrthoDB	1	1.010	-	-		D1310134at2759
OrthoFinder	1	1.000	-	-		FOG0006130
OrthoInspector	1	1.000	-	-		oto93717
orthoMCL	1	0.900	-	-		OOG6_101754
Panther	1	1.100	-	-	LDO	PTHR10942
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2617
SonicParanoid	1	1.000	-	-		X4421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750