Protein Alignment Invadolysin and Y43F4A.1

DIOPT Version :9

• Sequence 1: NP_652072.1
• Gene: Invadolysin / 49580
• FlyBaseID: FBgn0086359
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_001022870.1
• Gene: Y43F4A.1 / 176737
• WormBaseID: WBGene00012796
• Length: 663
• Species: Caenorhabditis elegans
• Alignment Length: 617
• Identity: 282/617 - (45%)
• Similarity: 375/617 - (60%)
• Gaps: 48/617 - (7%)

  Fly    35 CQHQHPKAHEVVHGVRIQLADSEDDSAGDPARHSVRRRSVAAEQ----------PLRILLVYDES 89
            |.:|:|:..:::..|.|:        ...|.||   ||.:.:..          ||||.|.||:|
 Worm    26 CSYQNPRIEDILLEVPIE--------HEHPHRH---RRGLPSSDPTSPPVEKFAPLRIQLHYDKS 79

  Fly    90 VYRLEEEKFNLINDTVLPEAVQFWEQALMVRETKGVIRLNRKCDSTQVYVKNG--HTHCIDHCKA 152
            :..|..|..|.:|.|:|||||.:||.||.||.....|||.|||.|:..|.|.|  :..|...|:.
 Worm    80 IQNLTAEVQNFVNTTLLPEAVGYWENALRVRPMTTPIRLRRKCISSFYYYKQGMRNVACDKGCRE 144

  Fly   153 TTMCGEVQVPDAHLDVCRVCNATGQNCRIDSNTQPGEGIENADFVFYVSARQTQRCFKGLTVAYA 217
            .|.|||..:|..||..|..||.| .:|:  :..:.|||:::.||:.||:|..::||....|::||
 Worm   145 RTTCGEADIPRDHLLDCLACNNT-DDCK--TTGELGEGVKDTDFILYVTAHDSKRCEGPETLSYA 206

  Fly   218 AHCQQEAALDRPIAGHANLCPESISTKPQELQTLISTVKHEILHALGFSVSLYAFFRDDDGKPRT 282
            |||||||..||||||:.||||.::|....:.:.|.|||||||||||||||.|||||||.:|||||
 Worm   207 AHCQQEADFDRPIAGNVNLCPSALSVHNHDYEILTSTVKHEILHALGFSVGLYAFFRDSEGKPRT 271

  Fly   283 PRKLDTGKP-YLNEKLQIHQWSNETIRKVVRENWSVRGGHVNKVVDMMVTPRVIAEVRAHFNCNK 346
            .|. ..|:| .||::...:.|.:.||..|:||||....|.|...:.|||||:|..|.|.||.|:|
 Worm   272 KRN-RYGRPTSLNKQKGYYDWDSNTITTVLRENWWTGEGKVIHPIHMMVTPKVREEARRHFGCDK 335

  Fly   347 LEGAELEDQGGEGTALTHWEKRILENEAMTGTHTQSPVFSRITLALMEDSGWYRANYSMATPLTW 411
            |||||||:||||||.|||||||..|||||||||||:||:||:|||.:||:|||:.||.:|..|.|
 Worm   336 LEGAELENQGGEGTYLTHWEKRAYENEAMTGTHTQNPVYSRLTLAFLEDTGWYQPNYEVAEDLHW 400

  Fly   412 GKGLGCAFAMRSCKDWIQYNHARGRSIHPFCSKVKQDPLQ----TECTDDRNSVALCNLIRHEFE 472
            ||.|||.|||:||.:||......|...:|:||.:|.|..:    |.||..|:|:|||||:..:.|
 Worm   401 GKQLGCDFAMKSCGEWIHEKKILGEDAYPYCSDIKHDGSKSMAITRCTTQRDSLALCNLVPFQKE 465

  Fly   473 LPKGYQNFDSLNHVKDGEEGFYGGSVSLADHCPYIQEFTWRSKNVIVRGSH----CRFTENNPRP 533
            ||..|:||.||..|......:|||||.:||:||::|||.|:   :|.:..|    |....|....
 Worm   466 LPSQYRNFMSLPGVNPDGAKYYGGSVEMADYCPFLQEFEWK---LIDKTQHKDSRCELEGNGKEG 527

  Fly   534 EKNFALESYGEGAKCFDHSESMWEERSCHQTREWQHWGSGCYKYDCFDGRLHILVGNYS----YK 594
            |.  .||.||..:|||:..:. |.||.|.:.|...|:.:|||::.|.:|.|:  ||:|:    |.
 Worm   528 ED--ILEVYGANSKCFEFPKP-WTERKCGRIRVLSHYMAGCYEHQCTNGTLY--VGSYNATDMYP 587

  Fly   595 CSFPGQKLSIRIAANGWLHKGAIMCPPCHELC 626
            |....||:.|:...:|||.:|:::||.|.:.|
 Worm   588 CYAENQKIHIKKVVDGWLREGSLICPKCEDYC 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Invadolysin	NP_652072.1	Peptidase_M8	93..628	CDD:302875	264/549 (48%)
Y43F4A.1	NP_001022870.1	Peptidase_M8	50..620	CDD:302875	275/585 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167421
Domainoid	1	1.000	450	1.000	Domainoid score	I261
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13198
Inparanoid	1	1.050	532	1.000	Inparanoid score	I657
Isobase	1	0.950	-	0	Normalized mean entropy	S3900
OMA	1	1.010	-	-		QHG48900
OrthoDB	1	1.010	-	-		D1310134at2759
OrthoFinder	1	1.000	-	-		FOG0006130
OrthoInspector	1	1.000	-	-		oto20635
orthoMCL	1	0.900	-	-		OOG6_101754
Panther	1	1.100	-	-	LDO	PTHR10942
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2617
SonicParanoid	1	1.000	-	-		X4421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890