DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Invadolysin and LMLN2

DIOPT Version :9

Sequence 1:	NP_652072.1	Gene:	Invadolysin / 49580	FlyBaseID:	FBgn0086359	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001341569.1	Gene:	LMLN2 / 100128908	HGNCID:	53647	Length:	788	Species:	Homo sapiens

Alignment Length:	727	Identity:	160/727 - (22%)
Similarity:	235/727 - (32%)	Gaps:	296/727 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VRIQ---LADSEDDSAGDPARHSVRRRSVAAEQPLRILLVYDESVYRLEEEKFNLINDTVLPEAV 110
            :|||   |.|...|.|.||....:|..|       |.|....|:..|::         .||  ||
Human    62 LRIQSCYLGDHISDGAWDPEGEGMRGGS-------RALAAVREATQRIQ---------AVL--AV 108

  Fly   111 QFWEQALMVRETKGVIRLNRKCDSTQVYVKNGHTHCIDHCKATTMCGEVQVPDAHLDVCRVCNA- 174
            |            |.:.|:|  |..|            :|.|  :.|:...|:.|.  |.:.|.
Human   109 Q------------GPLLLSR--DPAQ------------YCHA--VWGDPDSPNYHR--CSLLNPG 143

  Fly   175 -TGQNC---RIDSN----------------TQP-GEGIENADFVFYVSARQTQRCFK-------- 210
             .|::|   :|...                .|| |.|::|.||:.||....|.:|.:
Human   144 YKGESCLGAKIPDTHLRGYALWPEQGPPQLVQPDGPGVQNTDFLLYVRVAHTSKCHQETVSLCCP 208

  Fly   211 ------------GLT---------------------------------------VAYAAHCQQEA 224
                        .||                                       :||||.||.::
Human   209 GWSTAAQSQLTAALTSWAQRRGFVMLPRLCLKLLGSSNLPTLASQSIRITGPSVIAYAACCQLDS 273

  Fly   225 ALDRPIAGHANLCPESISTKPQELQTLISTVKHEILHALGFSVSLYAFFRDDDGKPRTPRKLDTG 289
            . |||:||....|.:.:::.......::....||:|||||||..|:..:||      .|....
Human   274 E-DRPLAGTIVYCAQHLTSPSLSHSDIVMATLHELLHALGFSGQLFKKWRD------CPSGFS-- 329

  Fly   290 KPYLNEKLQIHQWSNETIRKVVRENWSVR--------GGHVNKVVDMMVTPRVIAEVRAHFNCNK 346
                                 ||||.|.|        .|.:     ::.||.|...:..|...:.
Human   330 ---------------------VRENCSTRQLVTRQDEWGQL-----LLTTPAVSLSLAKHLGVSG 368

  Fly   347 LE-GAELEDQGGEGTALTHWEKRILENEAMTGTH--TQSPVFSRITLALMEDSGWYRANYSMATP 408
            .. |..||::  ||...:|||.|:|:...||.|.  .|......||||..:|||||:.|:|.|..
Human   369 ASLGVPLEEE--EGLLSSHWEARLLQGSLMTATFDGAQRTRLDPITLAAFKDSGWYQVNHSAAEE 431

  Fly   409 LTWGKGLGCAFAMRSCKDWIQYNHARGRSIHPFCSKVKQDPLQTECTDDRNSVALCNLIRHEFEL 473
            |.||:|.|..|.:.:.                 |.....|..   ||..       .|..|...|
Human   432 LLWGQGSGPEFGLVTT-----------------CGTGSSDFF---CTGS-------GLGCHYLHL 469

  Fly   474 PKGYQNFDSLNHVKDGEEGFYGGSVSLADHCPYIQEFTWRSKNVIVRGSHCRFTENN-PRPEKNF 537
            .||..:.|                 .:.:.|        |....:..||.|...||. |....|.
Human   470 DKGSCSSD-----------------PMLEGC--------RMYKPLANGSECWKKENGFPAGVDNP 509

  Fly   538 ALESYGEGAKCFD---HSESMWEERSCHQT-----REWQHWGSGCYKYDCFDGRLHILVGNYSYK 594
            ..|.|...::||.   .|:.:..::..|.:     :|.:..|. ||.:.|        .|..:||
Human   510 HGEIYHPQSRCFFANLTSQLLPGDKPRHPSLTPHLKEAELMGR-CYLHQC--------TGRGAYK 565

  Fly   595 CSFPGQKLSIRIAANGWL------------HKGAIMCPPCHELCGAQFAAQGKQCRPGEE----- 642
                     :::..:.|:            :.|.:.||            :|:.|:..|:
Human   566 ---------VQVEGSPWVPCLPGKVIQIPGYYGLLFCP------------RGRLCQTNEDINAVT 609

  Fly   643 --------PDPL 646
                    ||||
Human   610 SPPVSLSTPDPL 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Invadolysin	NP_652072.1	Peptidase_M8	93..628	CDD:302875	138/647 (21%)
LMLN2	NP_001341569.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..59
		Peptidase_M8	<254..602	CDD:302875	107/466 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1310134at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10942
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020