Protein Alignment OCRL and ocrl

DIOPT Version :10

• Sequence 1: NP_001305713.1
• Gene: OCRL / 4952
• HGNCID: 8108
• Length: 902
• Species: Homo sapiens
• Sequence 2: XP_009289414.1
• Gene: ocrl / 777716
• ZFINID: ZDB-GENE-061110-61
• Length: 961
• Species: Danio rerio
• Alignment Length: 967
• Identity: 575/967 - (59%)
• Similarity: 723/967 - (74%)
• Gaps: 72/967 - (7%)

Human     1 MEPPLPVGAQPLAHTVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHV-----QDIIPIN 60
            |||...:.......||.|.|::...:||..|:|.:.:||::|.| |...:..|     |..||||
Zfish     2 MEPSFGISESQCIATVRGHEIRSGQKEPRLLSLLECSGQFKLDI-LSNPDAIVLSPVSQLSIPIN 65

Human    61 SHFRCVQEAEETLLIDIAS-NSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVL-AAQKAQSQLL 123
            :|||.::||||.|||||.| :...:||::|:...|...|:.|:.....||..|. |.|:|:...|
Zfish    66 NHFRIIREAEEALLIDIDSISKTVRIRLRGERTPELLLELQDDGQTQSFLEHVTKAKQQAERSSL 130

Human   124 -----------------VPEQKDSS-SWYQKLDTK--------DKPSVFSGLLGFEDNFSS-MNL 161
                             ||.|:.:| |:...::..        |.....:...|||:||:. :.:
Zfish   131 PRKMEPVVPAPVKDCVPVPPQRGTSKSFSNNINNSTLANPSNTDSTRSLATDFGFEENFNHVLKV 195

Human   162 DKKINSQNQPTGIHREPPPPPFSVNKMLPRE-------KEASNKEQPKVTN-------------- 205
            ::|.|.||:... .|||||||  :..:.||:       ..|:.:..|.|.|
Zfish   196 EEKKNKQNRLVA-QREPPPPP--IPPLPPRKGTNTSLTGPATKERPPSVQNATPVRNEFQSVDRS 257

Human   206 ----------TMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQSPDSGLE 260
                      |:|:..: ::.:|.||||:|:.|:|:|||||:|:.|:|||||||||||||||.|.
Zfish   258 VSWSESPSNSTIRQAMM-SSHAGSREGLLKYRLSKKEKEYVDIKNFKFFVGTWNVNGQSPDSSLG 321

Human   261 PWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMML 325
            |||:.||:|||:|.:||||||||||||||.:|.|||.|..|||||||.||:|.:|:::|||||||
Zfish   322 PWLSSDPDPPDVYALGFQELDLSTEAFFYMDSSKEQLWVDAVERGLHQKARYIQVRIIRLVGMML 386

Human   326 LIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQD 390
            :::.:|:....||:||:|:||||:|.|||||||||||||||||:||.|||||||||:||||||||
Zfish   387 VVYIKKEHKDQIREIASESVGTGLMNKMGNKGGVAVRFVFHNTSFCFVNSHLAAHVDDFERRNQD 451

Human   391 YKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLN 455
            ||||||||||.:  ...|.::|:||:|||||||||||||:|||.|||.||.:|:|:||.::||||
Zfish   452 YKDICARMSFHL--LEYPPVSIVKHDVVIWLGDLNYRLCLPDAGEVKRLIAEKELRRLQEYDQLN 514

Human   456 IQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMEL 520
            :||..|:.|.||.||||.||||||||:|:||||||||||:|||||||||||:||.||:|||||||
Zfish   515 LQRKTKRVFTDFMEGEINFIPTYKYDAKSDRWDSSGKCRIPAWCDRILWRGSNVKQLHYRSHMEL 579

Human   521 KTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFENVKFRQLQK 585
            |||||||||::|.||||:|.|:||:|:||:.||.||||||||||||.|:||||.||||||||||:
Zfish   580 KTSDHKPVSSVFSIGVKMVIEQRYKKIFEEIVRDMDRMENDFLPSLSLTRREFTFENVKFRQLQR 644

Human   586 EKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSG 650
            :.|.|:|:|||.|.|:|||||||||||||||||||.||.|:|||.::|.|:|||||||||:||||
Zfish   645 QSFLITNDGQVACTFAFIPKLNDSQYCKPWLRAEPCEGVLDPNEKIEIFLEVYVSKDSVTLLNSG 709

Human   651 EDKIEDILVLHLDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEEDSFLEKE 715
            ||.||||||||||||||||:|:||||||||||||||.|||||:||||:|:||||||.|||.:|||
Zfish   710 EDNIEDILVLHLDRGKDYFITVSGNYLPSCFGTSLETLCRMKKPIREIPITKLIDLGEDSCMEKE 774

Human   716 KSLLQMVPLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPET 780
            |:.:..:....|..::||::|||:||||:||:..||.|||||||||:|:|||.||||||||||::
Zfish   775 KARMTFLLDSAGTEDKPLKIPKEVWLLVNHLYTKACQQEDLFQTPGLQDELQSIIDCLDTSIPDS 839

Human   781 IPGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLR 845
            |||.|||||||||||||||||||:||||:||||:.::|.|:|:|:||||||.|||||||||||||
Zfish   840 IPGCNHSVAEALLIFLEALPEPVLCYELFQRCLECSHDSRLCKQLISQLPRAHRNVFRYLMAFLR 904

Human   846 ELLKFSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEED 902
            ||||.|..|::|||::||||.|||:||||||..:||..|||:|..|:||||:..:||
Zfish   905 ELLKHSIDNNLNANLLATLFASLLIRPPPNLAGKQTQHDRQKANDFILGFLMAGDED 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OCRL	NP_001305713.1	PH_OCRL1	15..116	CDD:270182	42/107 (39%)
		Clathrin box 1	74..78		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..187		10/21 (48%)
		5-phosphatase	238..564		236/325 (73%)
		INPP5c_INPP5B	241..534	CDD:197327	214/292 (73%)
		ASH	565..679		89/113 (79%)
		RhoGAP_OCRL1	669..897	CDD:239845	161/227 (71%)
		Clathrin box 2	703..707		3/3 (100%)
ocrl	XP_009289414.1	PH_OCRL1	13..122	CDD:270182	41/109 (38%)
		INPP5c_INPP5B	302..593	CDD:197327	214/292 (73%)
		RhoGAP_OCRL1	728..956	CDD:239845	161/227 (71%)