Protein Alignment OCRL and Ocrl

DIOPT Version :10

• Sequence 1: NP_001305713.1
• Gene: OCRL / 4952
• HGNCID: 8108
• Length: 902
• Species: Homo sapiens
• Sequence 2: NP_569962.2
• Gene: Ocrl / 31157
• FlyBaseID: FBgn0023508
• Length: 850
• Species: Drosophila melanogaster
• Alignment Length: 921
• Identity: 269/921 - (29%)
• Similarity: 419/921 - (45%)
• Gaps: 166/921 - (18%)

Human    10 QPLAHTVEGMEMKGP--LREPCALTLAQRNGQYELIIQLH-------EKEQHVQDIIPINSHFRC 65
            :.:.:..|..::|||  .....||..:|..|.:.:|...:       ..|..:..:..|:.:|:.
  Fly    32 ETIEYIFEAYQIKGPEYSNRLLALVSSQSGGTFAIIAFSYLRTPLSSANELIINKVFAIDHNFQL 96

Human    66 VQEAEETLL---IDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQLLVPEQ 127
            .|:::.::.   .|:::.....|:..        :...:..|..:|::.|::.:...:|
  Fly    97 RQDSKSSITTQQFDLSTAEDGPIKYY--------YYATESHHYEEFVAKVISFKSTMAQ------ 147

Human   128 KDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPPPFSVNKMLPRE 192
                        .|..:|.        ||..:|..::|
  Fly   148 ------------HDPETVL--------NFRWLNDYRQI--------------------------- 165

Human   193 KEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQS-PD 256
                                         |.:|..|.|||.||:..:....:..|||||.:: .|
  Fly   166 -----------------------------GEVKQELKKRESEYIVYKDIIIYCATWNVNNKTCSD 201

Human   257 SG--LEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVK--EQEWSMAVERGLHSKAKYKKVQL 317
            |.  |..||.|...|||||.||.||||..|:|......|:  |::|...:...:|...:|:.:..
  Fly   202 SNNPLRAWLACSEKPPDIYAIGLQELDTPTKAMLNSTQVQAIEKQWIDKMMDSVHPDVEYEILMS 266

Human   318 VRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVE 382
            .|||..||.:..||...::|.....::|..||...:|||||||:....:....|.||||||||:.
  Fly   267 HRLVATMLTVIVRKQLRQHIIRCRPKSVARGIFNTLGNKGGVAISLQLNEGNICFVNSHLAAHMG 331

Human   383 DFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKS-LINKKDLQ 446
            ..|.|||||..|...:.| ...:|     |..|:.:.|:||||||:..|...:... |.:.:..:
  Fly   332 YVEERNQDYNAIVEGIRF-DDGRT-----ISDHDHIFWVGDLNYRIQEPPGQQRPGPLSDAQTYE 390

Human   447 RLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGTNVNQ 511
            .||::|||..:..:.|.|..:.||||||.||||||..||.:|||.|.|.||:|||:||:||.:.|
  Fly   391 LLLQYDQLRQEMRRGKCFEGYTEGEIKFRPTYKYDPGTDNYDSSEKQRAPAYCDRVLWKGTRIEQ 455

Human   512 LNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFE 576
            |.|.|.||::.||||||.|:|.:.||..||.:|::|.|:.::.:|:.|||..|.:.:.:....|.
  Fly   456 LAYNSIMEIRQSDHKPVYAVFQVKVKTRDEVKYKRVQEEVLKAVDKRENDNQPQINVEKTVIDFG 520

Human   577 NVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSK 641
            .|:|.:.....|.:.||..:|..|||..| :....|:|||..:|.:..|..:....|.|.:..:.
  Fly   521 TVRFNEPSTRDFNVYNNCPLPVDFSFKEK-DIHAICEPWLHVDPRQDSLLIDSARSIRLKMNANV 584

Human   642 DSVTILNSGEDKIE-----DILVLHLDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVT 701
            .::..|..   ||.     |||:||::.|:|.|:|::|:|.|||||.|:|.:||..||:.|....
  Fly   585 RTIAGLLR---KIRASDNFDILILHVENGRDIFITVTGDYQPSCFGLSMETMCRTDRPLSEYSQD 646

Human   702 KLIDLEEDSFLEKEKSLLQMVPLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEEL 766
            ::..|..|.                 :.|..:.:|:|.:||:|:|::....|...|  |.....|
  Fly   647 QIKQLMNDE-----------------SPEYRVTMPREFFLLIDYLYRQGSKQVGAF--PSYDSRL 692

Human   767 ------QQIIDCLDTSIPETIPGSNHSVAEALLIFLE----ALPEPVICYELYQRCLDSAYDPRI 821
                  ..:.|.|||...:..|.:..:.|:|||:.|:    ||.|||:  |....|.:.:.
  Fly   693 SLGAQFNSVRDWLDTWSDDPFPANAETAAQALLLLLDLPEHALLEPVV--ENLLECTNKSQ---- 751

Human   822 CRQVISQLPRCHRNVFRYLMAFLRELLKFSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSD-R 885
            ....||.|....||||.:|..|||..::...|   :.:.:|:.|..:|||.    ..|....| .
  Fly   752 AMDYISLLSPPKRNVFMHLCMFLRAGIESQFY---DLHQVASTFGRILLRS----TERAAWMDYH 809

Human   886 QRAIQFLLGFL 896
            .|.|||:..|:
  Fly   810 SRCIQFMRLFI 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OCRL	NP_001305713.1	PH_OCRL1	15..116	CDD:270182	18/112 (16%)
		Clathrin box 1	74..78		1/6 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..187		1/21 (5%)
		5-phosphatase	238..564		136/331 (41%)
		INPP5c_INPP5B	241..534	CDD:197327	125/298 (42%)
		ASH	565..679		33/118 (28%)
		RhoGAP_OCRL1	669..897	CDD:239845	70/239 (29%)
		Clathrin box 2	703..707		0/3 (0%)
Ocrl	NP_569962.2	INPP5B_PH	23..160	CDD:465268	23/161 (14%)
		INPP5c_INPP5B	185..478	CDD:197327	125/298 (42%)
		RhoGAP_OCRL1	614..823	CDD:239845	70/239 (29%)