Protein Alignment OCRL and syj1

DIOPT Version :10

• Sequence 1: NP_001305713.1
• Gene: OCRL / 4952
• HGNCID: 8108
• Length: 902
• Species: Homo sapiens
• Sequence 2: NP_596431.1
• Gene: syj1 / 2540270
• PomBaseID: SPBC2G2.02
• Length: 1076
• Species: Schizosaccharomyces pombe
• Alignment Length: 735
• Identity: 183/735 - (24%)
• Similarity: 302/735 - (41%)
• Gaps: 181/735 - (24%)

Human     8 GAQPLAHTVEGMEMKG---PLREPCALTLAQRNGQYELIIQ-------------------LHEK- 49
            |:.|:....||::|.|   .:......|.|.....:..:|:                   |.|:
pombe   288 GSIPIFWEQEGVQMFGQKIDITRSLEATRAAFEKHFTSLIEEYGPVHIINLLGTGSGERSLSERL 352

Human    50 EQHVQ-----DIIPI-----NSHFRCVQEAE----------ETLLIDIASNSGCKIRVQGDWIRE 94
            .||:|     |:|.:     :|..|..::|.          ||......:|.|..|.||....|
pombe   353 RQHIQLSPEKDLIHLTEFDYHSQIRSFEDANKIRPMIYSDAETFGFYFENNEGQSIVVQDGVFR- 416

Human    95 RRFEIPDEEHCLKFLSAVLAAQKAQSQLLVPE--------------QKDSSSWYQKLDTKDKPSV 145
                    .:||..|......|...|::.:.:              |..|:.|....|...:  :
pombe   417 --------TNCLDCLDRTNVIQNLVSRVFLEQVMIYTRQNAGYDFWQVHSTIWANNGDALAR--I 471

Human   146 FSGLLGFEDNFS---SMNLDKKINSQNQPTGIHREPPPPPFSVNKMLPREKEASNKEQPKVTNTM 207
            ::|....:.:|:   .:::...:|..::..|
pombe   472 YTGTGALKSSFTRKGKLSIAGALNDLSKSVG---------------------------------- 502

Human   208 RKLFVPNTQ-SGQREGL----------------------IKHILAKREKEYVNIQTFRFFVGTWN 249
             ::::.|.| .|::|.:                      :.|.|.|||.|:...:..:.||.::|
pombe   503 -RMYINNFQDKGRQETIDLLLGRLIDQHPVILYDPIHEYVNHELRKRENEFSEHKNVKIFVASYN 566

Human   250 VNGQSPDSGLEPWLNCDPNP-PDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAK- 311
            :||.|..:.||.||..:..| .|||.:||||: .|:.:.....:..|.:||...|:|.|:.|..
pombe   567 LNGCSATTKLENWLFPENTPLADIYVVGFQEIVQLTPQQVISADPAKRREWESCVKRLLNGKCTS 631

Human   312 ---YKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIV 373
               |.:::..:|||..|:||.::.....|:::......||:.|..||||.||:||.:.:|..|.:
pombe   632 GPGYVQLRSGQLVGTALMIFCKESCLPSIKNVEGTVKKTGLGGVSGNKGAVAIRFDYEDTGLCFI 696

Human   374 NSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKS 438
            .|||||...:::.|:.||:.|.:.:.|      ....:|..|:.|:|.||.|||:.: ...||..
pombe   697 TSHLAAGYTNYDERDHDYRTIASGLRF------RRGRSIFNHDYVVWFGDFNYRISL-TYEEVVP 754

Human   439 LINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRIL 503
            .|.:..|..|.::||||.|....|.|..|:|..|.|.||||:|..||.:|:|.|.|||||.||||
pombe   755 CIAQGKLSYLFEYDQLNKQMLTGKVFPFFSELPITFPPTYKFDIGTDIYDTSDKHRVPAWTDRIL 819

Human   504 WRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFED-----SVRIMDRMENDF- 562
            :||..|.. :|:| :.|..|||:|:.|.:...:..||..:.:.:||:     ...:.|..:..:
pombe   820 YRGELVPH-SYQS-VPLYYSDHRPIYATYEANIVKVDREKKKILFEELYNQRKQEVRDASQTSYT 882

Human   563 --------------LPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFSFIP-----KLND 608
                          :|.|..:..:      |.:|...|:.:...:..:|......|     :||.
pombe   883 LIDIAGSVAGKPNLIPHLPANGVD------KIKQPSSERSKWWFDDGLPAKSIAAPPGPEYRLNP 941

Human   609 SQYCKPWLRAEPFEGYLEPN 628
            |   :|   ..|||...||:
pombe   942 S---RP---INPFEPTAEPD 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OCRL	NP_001305713.1	PH_OCRL1	15..116	CDD:270182	28/143 (20%)
		Clathrin box 1	74..78		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..187		2/21 (10%)
		5-phosphatase	238..564		117/351 (33%)
		INPP5c_INPP5B	241..534	CDD:197327	112/298 (38%)
		ASH	565..679		15/69 (22%)
		RhoGAP_OCRL1	669..897	CDD:239845
		Clathrin box 2	703..707
syj1	NP_596431.1	COG5329	1..582	CDD:227637	60/339 (18%)
		COG5411	529..981	CDD:227698	139/448 (31%)