DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP4A and Atpalpha

DIOPT Version :9

Sequence 1:	NP_000695.2	Gene:	ATP4A / 495	HGNCID:	819	Length:	1035	Species:	Homo sapiens
Sequence 2:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster

Alignment Length:	1034	Identity:	622/1034 - (60%)
Similarity:	780/1034 - (75%)	Gaps:	2/1034 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     2 GKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKY 66
            |:|::|.:.:| :........|....|.::.......:||.|:::|:|::|:.|::|..||.|::
  Fly    10 GRADSYRVATV-IATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRF 73

Human    67 QTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQAS 131
            ||....|||.:.|.|.|.|||||||.||:.|||:|||.:.|.||...|:|:.|.:|.:|::||||
  Fly    74 QTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAS 138

Human   132 EGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQL 196
            ..:...||||||.|.|.|||:|||.|.||||.||:.|:.||||:|||.|||||:|:|..:.|:.|
  Fly   139 TSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDL 203

Human   197 VVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCL 261
            |:||:||:|.|||:||||||:.|:..||||||||||||||:|..|.|||:||||:|:|||||..:
  Fly   204 VLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAV 268

Human   262 EGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGY 326
            |||.:|:|::.||.|::||||.||||::..:||||.||.||:.:|.|:|:..|.|||::|..:||
  Fly   269 EGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGY 333

Human   327 TFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGT 391
            .:|.|::|.:.|:||.|||||||||||||:|||||:|||||:||||||||||||||.||||||||
  Fly   334 HWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGT 398

Human   392 LTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKR 456
            ||||||||:|:||||.|..|||||||||..:|::|..::||.|:.||||||.||.|||.||:.|:
  Fly   399 LTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKK 463

Human   457 IVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGA 521
            .|.|||||.||||..||.||:.|..|.|..|:.|:|||||||:|:|||..||..|||:|||||||
  Fly   464 EVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGA 528

Human   522 PERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEA 586
            |||:|||||:|.|.|:|..|||:.:|||..||:.||||||||||||...|....||.|:.|:.:.
  Fly   529 PERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDD 593

Human   587 MNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSET 651
            :|||...|.|.||:||||||||.|||||.|||:|||:||||||||||||||||.||||||||:||
  Fly   594 INFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNET 658

Human   652 VEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESC 716
            |||||.||.:||.:||.::|:|.|::|.:|:|:...:|.|.||.|.|:|||||||||||:|||.|
  Fly   659 VEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGC 723

Human   717 QRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFD 781
            ||:||||||||||||||||||||||||||||||||.:|.|||||||||||||||||||:||||||
  Fly   724 QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 788

Human   782 NLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLR 846
            |||||||||||.||||::|:|.:|...:|||||.:|||.|:|.||:.|::|||||.||:|||...
  Fly   789 NLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRP 853

Human   847 PRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQD 911
            ||:|..|:|||..|.:.:|.|||.||:.|||..||..||:.|:.|....|:|..|:...:.||.|
  Fly   854 PRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTD 918

Human   912 SYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCI 976
            |||||||:..|...:|||:|.|||||.|.|.||::|.||||.|.|||| .||..|...:||:..:
  Fly   919 SYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQG-MRNWALNFGLVFETVL 982

Human   977 GCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 1035
            ..||.|||||.......|::..||...:|:.:.||:|||.|:..:|..||.|.:||.||
  Fly   983 AAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP4A	NP_000695.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		6/38 (16%)
		H-K_ATPase_N	2..>22	CDD:312544	4/19 (21%)
		ATPase-IIC_X-K	43..1035	CDD:273445	612/991 (62%)
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	614/996 (62%)
		Cation_ATPase_N	58..132	CDD:214842	36/73 (49%)
		E1-E2_ATPase	152..383	CDD:278548	146/230 (63%)
		Cation_ATPase	445..539	CDD:289987	63/93 (68%)
		COG4087	<695..770	CDD:226572	62/74 (84%)
		Cation_ATPase_C	817..1025	CDD:279079	105/208 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830