DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Bb and FOXRED1

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_060017.1	Gene:	FOXRED1 / 55572	HGNCID:	26927	Length:	486	Species:	Homo sapiens

Alignment Length:	434	Identity:	178/434 - (41%)
Similarity:	268/434 - (61%)	Gaps:	26/434 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 HCDVLIIGGGGVGSSIAYWLK--EKARDGLNVVVVEKDDTYAQSATRVSVGGLCQQFSLPENIQM 159
            |.||:|:|||.:|.|:|||||  |..|..:.|:|||:|.||:|::|.:||||:|||||||||||:
Human    63 HSDVVIVGGGVLGLSVAYWLKKLESRRGAIRVLVVERDHTYSQASTGLSVGGICQQFSLPENIQL 127

  Fly   160 SLFAADFLRSARKHF----GEEVPLQFTPHGHLMLAGEEHAESLKRSSQLQNELGARNELLTADR 220
            |||:|.|||:..::.    ...:.|:|.|.|:|:||.|:.|.:::.:.::|.:.||:..|::.|:
Human   128 SLFSASFLRNINEYLAVVDAPPLDLRFNPSGYLLLASEKDAAAMESNVKVQRQEGAKVSLMSPDQ 192

  Fly   221 LTARFPWLNTKGIALGCLGLEKEGWFNPLALLSNFRRSASGYGAHFISGQVVDFEFKSQ----TD 281
            |..:|||:||:|:||...|:|.||||:|..||...||.....|..|..|:|..|...||    ||
Human   193 LRNKFPWINTEGVALASYGMEDEGWFDPWCLLQGLRRKVQSLGVLFCQGEVTRFVSSSQRMLTTD 257

  Fly   282 ISVVTDLGSNEGAYTGLEKAVIQLPDGTRRTCKFALCVISAGASSEQIARLARIGVG-PGILR-V 344
            ...|. |......:..:::::...|      .:.|:.:.:|||.|.|||.||.:|.| ||.|: .
Human   258 DKAVV-LKRIHEVHVKMDRSLEYQP------VECAIVINAAGAWSAQIAALAGVGEGPPGTLQGT 315

  Fly   345 PLPINARKRYMYAINSQAQSAPGMNMPMTIDPSGIFIRRDGLGGNYICVQDSTEEYN----SAMI 405
            .||:..||||:|..:  ....||:..|:..|.||.:.||:|||.||:..:..||:..    :..:
Human   316 KLPVEPRKRYVYVWH--CPQGPGLETPLVADTSGAYFRREGLGSNYLGGRSPTEQEEPDPANLEV 378

  Fly   406 DPQYFAQHIRPHLYNRIPVLGEAQVVDSWAGCYDHNVYDENGILGAHPYYNNLYLATGFSGHGVQ 470
            |..:|...:.|||..|:|.....:|..:|||.||:|.:|:||::|.||...|:|.||||||||:|
Human   379 DHDFFQDKVWPHLALRVPAFETLKVQSAWAGYYDYNTFDQNGVVGPHPLVVNMYFATGFSGHGLQ 443

  Fly   471 QSLAVGRAISELIMDGQFRTIDLSRLSFDRLIVDQPMFELNNVL 514
            |:..:|||::|:::.|:|:|||||...|.|..:.:.:.| ||::
Human   444 QAPGIGRAVAEMVLKGRFQTIDLSPFLFTRFYLGEKIQE-NNII 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	165/403 (41%)
FOXRED1	NP_060017.1	DadA	77..478	CDD:223737	167/409 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2853
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9712
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62229
OrthoDB	1	1.010	-	-		D393377at33208
OrthoFinder	1	1.000	-	-		FOG0003481
OrthoInspector	1	1.000	-	-		otm41660
orthoMCL	1	0.900	-	-		OOG6_105163
Panther	1	1.100	-	-	O	PTHR13847
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3938
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.720