DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Bb and PDPR

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001309046.1	Gene:	PDPR / 55066	HGNCID:	30264	Length:	879	Species:	Homo sapiens

Alignment Length:	469	Identity:	95/469 - (20%)
Similarity:	176/469 - (37%)	Gaps:	119/469 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ETEKVPIPTQSQFHFSGERDKSKEATVPDDFQTHCDVLIIGGGGVGSSIAYWLKEKARDGLNVVV 128
            |...:.:|||:|                        |:|.|||..|:|:||.|   ::.|...:|
Human    33 EARSMALPTQAQ------------------------VVICGGGITGTSVAYHL---SKMGWKDIV 70

  Fly   129 VEKDDTYAQSATRVSVGGLCQQFSLPENIQMSLFAADFLRSARKHFGEEVPLQ--FTPHGHLMLA 191
            :.:....|..:||...|.|    |...::.:....||:.........:|..:|  :|..|.:.||
Human    71 LLEQGRLAAGSTRFCAGIL----STARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFLA 131

  Fly   192 -GEEHAESLKRSSQLQNELGARNELLTADRLTARFPWLNTKGIALGCLGLEKEGWFN----PLAL 251
             .::...||||.:...|.:|..:|:::..::......||...: :|.:.:.::...:    .|||
Human   132 QTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDL-VGAMHVPEDAVVSSADVALAL 195

  Fly   252 LSNFRRSASGYGAHFISGQVVDFEFKSQTDISVVTDLGSNEGAYTGLEKAVIQLPDGTRRTCK-F 315
            .|    :||..|....             |.:.|..:...:|..||:|      .|..:..|: |
Human   196 AS----AASQNGVQIY-------------DRTSVLHVMVKKGQVTGVE------TDKGQIECQYF 237

  Fly   316 ALC----VISAGASSEQIARLARIGVGPGILRVPLPINARKRYMYAINSQAQSAPGMNMPMTIDP 376
            ..|    ....|.|:|:              .|.:|::|.:.: |.:....::....:.|..:|.
Human   238 VNCAGQWAYELGLSNEE--------------PVSIPLHACEHF-YLLTRPLETPLQSSTPTIVDA 287

  Fly   377 SG-IFIR--RDGL---------------GGNYICVQDSTEEYNSAMIDPQYFAQHIRP---HLYN 420
            .| |:||  :.|:               |.|.:.:|:..|:::           |..|   .|..
Human   288 DGRIYIRNWQGGILSGGFEKNPKPIFTEGKNQLEIQNLQEDWD-----------HFEPLLSSLLR 341

  Fly   421 RIPVLGEAQVVDSWAGCYDHNVYDENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELIMD 485
            |:|.|...::: ....|.:....|...|:|..|.....::..|.:..|:......|:.::|.::.
Human   342 RMPELETLEIM-KLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVH 405

  Fly   486 G----QFRTIDLSR 495
            |    ....:||.|
Human   406 GYPSENVWELDLKR 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	83/420 (20%)
PDPR	NP_001309046.1	NADB_Rossmann	5..>74	CDD:304358	17/67 (25%)
		DadA	39..426	CDD:223737	94/463 (20%)
		FAO_M	405..460	CDD:292961	4/15 (27%)
		GcvT	453..830	CDD:223481
		GCV_T	463..736	CDD:279857
		GCV_T_C	748..852	CDD:285832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151900
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840