DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Bb and PIPOX

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_057602.2	Gene:	PIPOX / 51268	HGNCID:	17804	Length:	390	Species:	Homo sapiens

Alignment Length:	451	Identity:	98/451 - (21%)
Similarity:	151/451 - (33%)	Gaps:	158/451 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 DVLIIGGGGVGSSIAYWLKEKARDGLNVVVVEKDDTYAQSATRVSVGGLCQQFSLPENIQMSLFA 163
            |.::||.|..|...||.|                   |:...|:.   |.:||.||.:...|...
Human     9 DAIVIGAGIQGCFTAYHL-------------------AKHRKRIL---LLEQFFLPHSRGSSHGQ 51

  Fly   164 ADFLRSAR----------------KHFGEEVPLQFTPHGHLMLAGEEHAESLKRSSQLQNELGAR 212
            :..:|.|.                .....|...|......|:|.|.:..:.||......:.....
Human    52 SRIIRKAYLEDFYTRMMHECYQIWAQLEHEAGTQLHRQTGLLLLGMKENQELKTIQANLSRQRVE 116

  Fly   213 NELLTADRLTARFPWLNTKGIALGCLGLEKEGWFNPLALLSNFRRSASGYGAHFISGQVVDFEFK 277
            ::.|:::.|..|||.:.   :..|.:|           ||.|             ||.|: :.:|
Human   117 HQCLSSEELKQRFPNIR---LPRGEVG-----------LLDN-------------SGGVI-YAYK 153

  Fly   278 SQTDI-SVVTDLGSNEGAYTGLEKAVIQLPDG-------TRRTCKFALCVISAGASSEQIARLAR 334
            :...: ..:..||   |.....|| |:::..|       |.|:.:....||:||..:.|:.|
Human   154 ALRALQDAIRQLG---GIVRDGEK-VVEINPGLLVTVKTTSRSYQAKSLVITAGPWTNQLLR--- 211

  Fly   335 IGVGPGILRVPLPINARKRYMYAINSQAQSAPGMNMPMTIDPSGIFIRRDGLGGNY--------- 390
                      ||                    |:.||:......:...|:.:.|:|
Human   212 ----------PL--------------------GIEMPLQTLRINVCYWREMVPGSYGVSQAFPCF 246

  Fly   391 ----ICVQD----STEEYNSAM---------IDP---------------QYFAQHIRPHLYNRIP 423
                :|...    .|.||...|         .||               |..:..:|.||.:..|
Human   247 LWLGLCPHHIYGLPTGEYPGLMKVSYHHGNHADPEERDCPTARTDIGDVQILSSFVRDHLPDLKP 311

  Fly   424 VLGEAQVVDSWAGCYDHNVYDENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELIM 484
               |..|::|   |...|..||..||..||.|:|:.:..||||||.:.:..||:.:.||.|
Human   312 ---EPAVIES---CMYTNTPDEQFILDRHPKYDNIVIGAGFSGHGFKLAPVVGKILYELSM 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	93/437 (21%)
PIPOX	NP_057602.2	soxA_mon	8..388	CDD:130444	98/451 (22%)
		NAD_binding_8	12..>38	CDD:290186	10/47 (21%)
		Microbody targeting signal. /evidence=ECO:0000255	388..390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D752680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920