DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Bb and DMGDH

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_037523.2	Gene:	DMGDH / 29958	HGNCID:	24475	Length:	866	Species:	Homo sapiens

Alignment Length:	492	Identity:	113/492 - (22%)
Similarity:	201/492 - (40%)	Gaps:	115/492 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 EKVPIPTQSQFHFSGERDKSKEATVPDDFQTHCDVLIIGGGGVGSSIAYWLKEKARDGL-NVVVV 129
            ||.|:..::|:     :|::             :.:|||||.||.|:||.|   |:.|: :||::
Human    36 EKPPLSAETQW-----KDRA-------------ETVIIGGGCVGVSLAYHL---AKAGMKDVVLL 79

  Fly   130 EKDDTYAQSATRVSVGGLCQQFSLPENIQMSLFAADFLRSARKHFGEEV--PLQFTPHGHLMLAG 192
            ||.:..|.|....:  ||...|.  ..|.:.....|.::...| ..||.  .:.|...|.:.||.
Human    80 EKSELTAGSTWHAA--GLTTYFH--PGINLKKIHYDSIKLYEK-LEEETGQVVGFHQPGSIRLAT 139

  Fly   193 -----EEHAESLKRSSQLQNELGARNELLTADRLTARFPWLNTKGIALGCLGLEKEGWFNPLALL 252
                 :|....:.|:.....|    ..|:..:::...||.||...:..| |....:|..:|.:|.
Human   140 TPVRVDEFKYQMTRTGWHATE----QYLIEPEKIQEMFPLLNMNKVLAG-LYNPGDGHIDPYSLT 199

  Fly   253 SNFRRSASGYGAHFISGQVVDFEFKSQTDISVVTDL-GSNEGAYTGLEKAVIQLPDGTRRTCKFA 316
            ......|...||      ::.:.       :.||.| ..::|.:.      ::.|.|:.|..:.
Human   200 MALAAGARKCGA------LLKYP-------APVTSLKARSDGTWD------VETPQGSMRANRI- 244

  Fly   317 LCVISAGASSEQIARLARIGVGPGILRVPL-PINARKRYMYAINSQAQSAPGM--NMPMTIDPSG 378
              |.:||..:.::.::  ||     |..|| |:    ::.|.:.|.......:  .:|:..|..|
Human   245 --VNAAGFWAREVGKM--IG-----LEHPLIPV----QHQYVVTSTISEVKALKRELPVLRDLEG 296

  Fly   379 IFI---RRDG-LGGNY-----ICVQDS-----------TEEYNSAMIDPQYFAQHIRPHLYNRIP 423
            .:.   .||| |.|.|     :.||||           .|.:.|   |.....:||:..: ..:|
Human   297 SYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFES---DLDRIMEHIKAAM-EMVP 357

  Fly   424 VLGEAQVVDSWAG--CYDHNVYDENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELIMDG 486
            ||.:|.:::...|  .|..::..   ::|.|....|.::|.|| |:|:..:..||:.:|:.|:.|
Human   358 VLKKADIINVVNGPITYSPDILP---MVGPHQGVRNYWVAIGF-GYGIIHAGGVGKYLSDWILHG 418

  Fly   487 Q--FRTIDLSRLSFDRLIVDQ-------PMFELNNVL 514
            :  |..|:|....:.:....|       ..:..||::
Human   419 EPPFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIV 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	97/423 (23%)
DMGDH	NP_037523.2	NADB_Rossmann	44..>90	CDD:304358	21/66 (32%)
		DadA	47..435	CDD:223737	106/454 (23%)
		FAO_M	417..472	CDD:292961	7/39 (18%)
		GcvT	464..857	CDD:223481
		GCV_T	482..745	CDD:279857
		GCV_T_C	753..845	CDD:285832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D752680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920