DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Bb and Dmgdh

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_038957650.1	Gene:	Dmgdh / 245961	RGDID:	620453	Length:	884	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	121/560 - (21%)
Similarity:	216/560 - (38%)	Gaps:	131/560 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRYRQVVGLLQRRNFSAGATSNGSGSSGGDKSGE--DLHPIRRTLRLLGNDMRKVKEFFVPKEP 63
            |||    :|.|:.|.. |..:|.|..||.|.:.|.  :|:|
  Rat     1 MLR----LGALRLRGL-ALRSSQGRPSSAGLREGTVFELYP------------------------ 36

  Fly    64 ETEKVPIPTQSQF-HFS-GERDKSKEATVPD--DFQTHCDVLIIGGGGVGSSIAYWLKEKARDGL 124
                 .|.:.:.| |.: |:...|::.:.|.  :::...:.:|||||.||.|:||.|   |:.|:
  Rat    37 -----AILSSADFCHGACGKPAYSRQESPPSPPEWKDRAETVIIGGGCVGVSLAYHL---AKAGM 93

  Fly   125 -NVVVVEKDDTYAQSATRVSVGGLCQQFSLPENIQMSLF-AADFLRSARKHFGEEVPLQFTPHGH 187
             :||::||.:..|.|....:  ||...|....|::...: :........:..|:.|  .|...|.
  Rat    94 RDVVLLEKSELTAGSTWHAA--GLTTYFHPGINLKKIHYDSIKLYERLEEETGQVV--GFHQPGS 154

  Fly   188 LMLA-GEEHAESLKRSSQLQNELGARNELLTADRLTARFPWLNTKGIALGCLGLEKEGWFNPLAL 251
            :.|| ..|..:..|......|.......::..:::...||.||...|..| |....:|..:|.:|
  Rat   155 IRLATTPERVDEFKYQMTRTNWHATEQYIIEPEKIHELFPLLNMDKILAG-LYNPGDGHIDPYSL 218

  Fly   252 LSNFRRSASGYGAHFISGQVVDFEFKSQTDISVVTDLGSN-EGAYTGLEKAVIQLPDGTRRTCKF 315
            .......|..|||      ::.:.       :.||.|... :|.:.      ::.|.|:.|..:.
  Rat   219 TMALATGARKYGA------LLKYP-------APVTSLKPRPDGTWD------VETPQGSVRANRI 264

  Fly   316 ALCVISAGASSEQIARLARIGVGPGILRVPLPINARKRYMYAINSQAQSAPGM--NMPMTIDPSG 378
               |.:||..:.::.::  ||:...::.|        ::.|.|.|.......:  .:|:..|..|
  Rat   265 ---VNAAGFWAREVGKM--IGLDHPLIPV--------QHQYVITSTIPEVKALKRELPVLRDLEG 316

  Fly   379 IFI---RRDG-LGGNYICVQDSTEEYNSAMIDPQYFAQHIRP----------------HL---YN 420
            .:.   .||| |.|.|       |......:...:.|..:.|                |:   ..
  Rat   317 SYYLRQERDGLLFGPY-------ESQEKMKLQASWVAHGVPPGFGKELFESDLDRITEHVEAAME 374

  Fly   421 RIPVLGEAQVVDSWAG--CYDHNVYDENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELI 483
            .:|||.:|.:::...|  .|..::..   ::|.|....|.::|.|| |:|:..:..||..:|:.|
  Rat   375 MVPVLKKADIINIVNGPITYSPDILP---MVGPHQGVRNYWVAIGF-GYGIIHAGGVGTYLSDWI 435

  Fly   484 MDGQ--FRTIDLSRLSFDRLIVDQ-------PMFELNNVL 514
            :.|:  |..|:|....:.:....|       ..:..||::
  Rat   436 LHGEPPFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIV 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	89/420 (21%)
Dmgdh	XP_038957650.1	DadA	67..455	CDD:223737	97/438 (22%)
		FAO_M	437..492	CDD:406692	7/39 (18%)
		GcvT	508..877	CDD:223481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D752680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920