DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Bb and Foxred1

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_758495.1	Gene:	Foxred1 / 235169	MGIID:	2446262	Length:	493	Species:	Mus musculus

Alignment Length:	524	Identity:	185/524 - (35%)
Similarity:	281/524 - (53%)	Gaps:	88/524 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RRTLRL-LG-----------------------NDMRKVKEFFVPKEP-----ETEKVPIPTQSQF 76
            ||.||| ||                       :|.:|..:..:|.:.     :|..:| |.|:
Mouse     3 RRALRLGLGPGLPYRGLRTRKGGFTLDWDAKVSDFKKKVDSILPGKKYEVLYDTSHLP-PEQA-- 64

  Fly    77 HFSGERDKSKEATVPDDFQTHCDVLIIGGGGVGSSIAYWLK--EKARDGLNVVVVEKDDTYAQ-S 138
                                  ||:|||||.:|.|:|:|||  |..|..:.|:|||:|.||:: |
Mouse    65 ----------------------DVVIIGGGILGLSVAFWLKKLESRRGAIRVLVVEQDHTYSRAS 107

  Fly   139 ATRVSVGGLCQQFSLPENIQMSLFAADFLRSARKHF----GEEVPLQFTPHGHLMLAGEEHAESL 199
            :|..||||:.||||:|||:|:|||:.:|||:..::.    ...|.|||.|.|.|:||.|:.|.:|
Mouse   108 STGPSVGGIWQQFSVPENVQLSLFSINFLRNINEYLAVVDAPPVELQFNPSGCLLLASEKDAATL 172

  Fly   200 KRSSQLQNELGARNELLTADRLTARFPWLNTKGIALGCLGLEKEGWFNPLALLSNFRRSASGYGA 264
            :.:.::|.:.||:..|::.::|..:|||:|.:|:||...|||.||||:..:||...||.....|.
Mouse   173 ENNVKMQRQEGAKVCLMSPEQLQTKFPWINVEGVALASYGLEDEGWFDAWSLLQGLRRKVQSMGV 237

  Fly   265 HFISGQVVDF-----EFKSQTDISVVTDLGSNEGAYTGLEKAVIQLPDGTRRTCKFALCVISAGA 324
            .|..|:|..|     ..|:.|...||  |......:..::|::...|      .:.|:.:.:|||
Mouse   238 FFCQGEVTRFITSSTPMKTPTGEHVV--LRRINNVHVKMDKSLEYQP------VECAVVINAAGA 294

  Fly   325 SSEQIARLARIGVG-PGILR-VPLPINARKRYMYAINSQAQSAPGMNMPMTIDPSGIFIRRDGLG 387
            .|.:||.||.:|.| ||.|: ..||:..||||::..:  ....||:..|:..|.||::.||:|||
Mouse   295 WSGKIAELAGVGKGLPGTLQGTKLPVEPRKRYVHLWH--CPQGPGLETPLVADISGVYFRREGLG 357

  Fly   388 GNYICVQDSTEEY----NSAMIDPQYFAQHIRPHLYNRIPV------LGEAQVVDSWAGCYDHNV 442
            .||:.....|||.    .:..:|..:|...:.|||..|:|.      |...||..:|||.||:|.
Mouse   358 SNYLGGCSPTEEEEPDPTNLNVDHDFFQNKVWPHLVQRVPSFKTLEHLLHLQVQSAWAGYYDYNT 422

  Fly   443 YDENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELIMDGQFRTIDLSRLSFDRLIVDQPM 507
            :|:||::|.||...|:|.||||||.|:|.:..:|||::|::::|.|:|||:|...|.|..:.:.:
Mouse   423 FDQNGVVGPHPLVVNMYFATGFSGRGLQHAPGIGRAVAEIMLEGHFKTIDMSPFLFTRFYLGEKL 487

  Fly   508 FELN 511
            .|.|
Mouse   488 QEYN 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	159/411 (39%)
Foxred1	NP_758495.1	DadA	60..485	CDD:223737	172/459 (37%)
Foxred1	NP_758495.1	NADB_Rossmann	65..>98	CDD:304358	17/32 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842032
Domainoid	1	1.000	329	1.000	Domainoid score	I1159
eggNOG	1	0.900	-	-		E1_KOG2853
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9712
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2266
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62229
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003481
OrthoInspector	1	1.000	-	-		otm43706
orthoMCL	1	0.900	-	-		OOG6_105163
Panther	1	1.100	-	-	O	PTHR13847
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3938
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760