DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Bb and AgaP_AGAP009080

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_319829.4	Gene:	AgaP_AGAP009080 / 1280035	VectorBaseID:	AGAP009080	Length:	521	Species:	Anopheles gambiae

Alignment Length:	523	Identity:	269/523 - (51%)
Similarity:	363/523 - (69%)	Gaps:	44/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RRNFSAGATSNGSGSSGGD-KSGEDL---------HPIRRTLRLLGNDMRKVKEFFVPKEPETEK 67
            ||.::    |:|.||.||. |...|.         :||.|||:|:|||::::|:|.:|
Mosquito    17 RRQYA----SSGEGSKGGSGKPSGDFSDQVEANKDNPISRTLKLIGNDVQRMKKFILP------- 70

  Fly    68 VPIPTQSQFHFSGERDKSKEATVP----------DDFQTHCDVLIIGGGGVGSSIAYWLKEKARD 122
                  |.:...|.:..|.::...          |.||:|||||:|||||||||||||||::||.
Mosquito    71 ------SSYTNPGAKGDSPDSANSIENYLERYRRDGFQSHCDVLVIGGGGVGSSIAYWLKKRARQ 129

  Fly   123 GLNVVVVEKDDTYAQSATRVSVGGLCQQFSLPENIQMSLFAADFLRSARKHFGEEVPLQFTPHGH 187
            ||||||:|||.||||::|.:|||||.||||:.|||||||:.|||:|::|.:.|::|.|.|||||:
Mosquito   130 GLNVVVLEKDATYAQASTCLSVGGLRQQFSIVENIQMSLYGADFMRNSRDYLGDDVDLNFTPHGY 194

  Fly   188 LMLAGEEHAESLKRSSQLQNELGARNELLTADRLTARFPWLNTKGIALGCLGLEKEGWFNPLALL 252
            |:||.|..||.|:::|:||..|||:||||||.||..||||:||:||||||.||||||||:|.|||
Mosquito   195 LLLASEAGAEQLEQNSKLQCALGAKNELLTAKRLKERFPWMNTEGIALGCHGLEKEGWFDPWALL 259

  Fly   253 SNFRRSASGYGAHFISGQVVDFEFKSQTDISVVTDLGSNEGAYTGLEKAVIQLPDGTRRTCKFAL 317
            |.||:.|..||||::.|::|.|.|:.|.||...   |..||:|.|:::|.:::.||..|..|||:
Mosquito   260 SGFRKRAIEYGAHYVEGEMVGFGFRQQPDILAE---GIEEGSYEGIDRAFVKMKDGEMREIKFAI 321

  Fly   318 CVISAGASSEQIARLARIGVGPGILRVPLPINARKRYMYAINSQAQSAPGMNMPMTIDPSGIFIR 382
            .:|:|||.|..||::||||.|.|:|.:|||:..||||:|....:....||:|.|:||||||.:.|
Mosquito   322 AIIAAGAQSGAIAKMARIGTGKGMLSIPLPVEPRKRYVYVFQCENDQGPGINTPLTIDPSGTYFR 386

  Fly   383 RDGLGGNYICVQDSTEE----YNSAMIDPQYFAQHIRPHLYNRIPVLGEAQVVDSWAGCYDHNVY 443
            ||||||||:..:....|    .::..:|..:|.:.:.|:|...:|.....:|.::|||.|:.|.:
Mosquito   387 RDGLGGNYLGGKSPLPEEEPPVDNLDVDHTFFDKTVWPNLAQMVPAFEAIKVKNAWAGYYEFNTF 451

  Fly   444 DENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELIMDGQFRTIDLSRLSFDRLIVDQPMF 508
            |||||:|.||||||||:||||||||:||:.|||||:||:|:||.|||:||:|..|||:||||||:
Mosquito   452 DENGIVGPHPYYNNLYIATGFSGHGIQQTPAVGRAVSEMIIDGGFRTVDLTRFGFDRIIVDQPMY 516

  Fly   509 ELN 511
            |.|
Mosquito   517 EAN 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	217/391 (55%)
AgaP_AGAP009080	XP_319829.4	DadA	120..508	CDD:223737	216/390 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	456	1.000	Domainoid score	I1561
eggNOG	1	0.900	-	-		E1_KOG2853
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9712
Inparanoid	1	1.050	534	1.000	Inparanoid score	I2811
OMA	1	1.010	-	-		QHG62229
OrthoDB	1	1.010	-	-		D393377at33208
OrthoFinder	1	1.000	-	-		FOG0003481
OrthoInspector	1	1.000	-	-		otm50746
Panther	1	1.100	-	-	O	PTHR13847
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3938
TreeFam	1	0.960	-	-
	13	12.940