DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Bb and AgaP_AGAP007123

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_308638.4	Gene:	AgaP_AGAP007123 / 1269983	VectorBaseID:	AGAP007123	Length:	897	Species:	Anopheles gambiae

Alignment Length:	457	Identity:	105/457 - (22%)
Similarity:	174/457 - (38%)	Gaps:	84/457 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LRLLGNDMRKVKEFFVPKEPETEKVPIPTQSQFHFSGERDKSKEATVPDDFQTHCDVLIIGGGGV 108
            |||..|.:.|.|......|   ::..|...|      .|..|.|:.:|:.    .||:|||||..
Mosquito     2 LRLRANAVAKFKSHIAGGE---QRAIIAATS------ARKYSTESPLPES----ADVVIIGGGSA 53

  Fly   109 GSSIAYWLKEKARDGLNVVVVEKDDTYAQSATRVSVGGLCQQFSLPENIQMSLFAA--DFLRSAR 171
            |.:..|.|   |:.|:..|::||....|  .|.....||..:.. |.::::.|.||  |.|.|..
Mosquito    54 GCNTLYQL---AKRGVRAVLLEKSKLTA--GTTWHTAGLVWRLR-PNDVEIRLLAATRDLLMSLE 112

  Fly   172 KHFGEEVPLQFTPHGHLMLA-GEEHAESLKRSSQLQNELGARNELLTADRLTARFPWLNTKGIAL 235
            :..|..  ..:..:|.|.:: ..|..:...|.:.|....|..:.::..::....||.|:.....
Mosquito   113 EETGHN--SGWINNGGLFISHSPERLDEYSRLATLGKCFGIDSHIVGPEQAQKLFPPLDPTSFT- 174

  Fly   236 GCLGLEKEGWFNPLALLSNFRRSASGYGAHFISGQVVDFEFKSQTDISVVTDLGSN-------EG 293
            |.|....:|..:|..:.:...:.|:..|     |.||:....||    ::|  |.|       .|
Mosquito   175 GALYSPGDGVVDPAMMCTALTKGATANG-----GLVVEDCTVSQ----IIT--GENLLGMKDVRG 228

  Fly   294 AYTGLEKAVIQLPDGTRRTCKFALCVISAGASSEQIARLARIGVGPGILRVPLPINARKRYMYAI 358
            ..|.         .||.||   ...|.:.|.....:       :.|  |.|.||:...| :.|.:
Mosquito   229 VLTN---------KGTIRT---NTVVNATGVWGRDL-------IEP--LGVFLPLIPMK-HAYVV 271

  Fly   359 NSQAQSAPGMNMPMTIDPS-GIFIRRDG----LGG---NYICVQDSTEEYNSAMIDPQY--FAQH 413
            :....:...| :|...|.. .::.|..|    :||   |.|.:.....:::..:.|..|  |..|
Mosquito   272 SETMDTIHQM-LPNVRDHDFSLYFRIQGKSICMGGYENNPIMLNRVPGDFHFGLYDLDYSVFDTH 335

  Fly   414 IRPHLYNRIPVLGEAQVVDSWAGCYDHNVYDENGILGAHPYYNNLYLATGFS------GHGVQQS 472
            |:..: ...|..|.|.:..:..| .:....|...::|..|..:.|:.:.|::      |.|..:.
Mosquito   336 IQGAV-KLCPAFGSAGIKSTICG-PESFTPDHKPLMGPDPTVSGLFHSVGYNSAGMMLGGGCAEQ 398

  Fly   473 LA 474
            ||
Mosquito   399 LA 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	84/388 (22%)
AgaP_AGAP007123	XP_308638.4	DadA	39..422	CDD:223737	93/411 (23%)
		NADB_Rossmann	43..>82	CDD:304358	17/43 (40%)
		FAO_M	405..457	CDD:292961
		GcvT	462..894	CDD:223481
		GCV_T	463..778	CDD:279857
		GCV_T_C	783..877	CDD:285832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910