DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Bb and dmgdh

DIOPT Version :9

Sequence 1:	NP_536791.1	Gene:	l(2)37Bb / 49427	FlyBaseID:	FBgn0002021	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_021324608.1	Gene:	dmgdh / 100141496	ZFINID:	ZDB-GENE-080227-8	Length:	862	Species:	Danio rerio

Alignment Length:	443	Identity:	99/443 - (22%)
Similarity:	171/443 - (38%)	Gaps:	70/443 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 IPTQSQFHFSGERDKSKEATVPDDFQTHCDVLIIGGGGVGSSIAYWLKEKARDGLNVVVVEKDDT 134
            :|.:....|:.:..::....:....|...|.|:||||.||.|:||.|.:..:.  :||::||.:.
Zfish    20 VPRERARSFATDPREASAGVLARRLQDSADTLVIGGGCVGVSVAYHLAKAGQK--DVVLLEKSEL 82

  Fly   135 YAQSATRVSVGGLCQQFSLPENI-QMSLFAADFLRSARKHFGEEVPLQFTPHGHLMLAGEE-HAE 197
            .|.|....:  ||...:....|: ::..::...........|:.|  .|...|.:.||... ..:
Zfish    83 TAGSTWHAA--GLTTYYHPGINLKKIHYYSIKLFEQLEAETGQAV--GFHQPGSIRLASTPVRVD 143

  Fly   198 SLKRSSQLQNELGARNELLTADRLTARFPWLNTKGIALGCLGLEKEGWFNPLALLSNFRRSASGY 262
            .||..............|:..:|:...||.||...:..| |....:|..:|.:|.......|..|
Zfish   144 ELKYQMSRTRWHPTPQFLIEPERIQQLFPLLNMDKVLAG-LYNPGDGHIDPYSLTMALAAGARMY 207

  Fly   263 GAHFISGQVVDFEFKSQTDISVVTDLGSNE-GAYTGLEKAVIQLPDGTRRTCKFALCVISAGASS 326
            ||.....             :.||.|...| |.:.      :|.|.||.|..:.   |.:.|..:
Zfish   208 GAQIYCP-------------AAVTGLTPTEDGRWD------VQTPHGTIRANRI---VNATGFWA 250

  Fly   327 EQIARLARIGVGPGILRVPLPINARKRYMYAINSQAQSAPGM--NMPMTIDPSGIFI---RRDG- 385
            .::.::.      |.....:|::    :.|.:.........:  .:|:..|..|.:.   .|||
Zfish   251 RELGQML------GFPHPTVPVH----HQYVVTGSVPEVQALQTELPVIRDLEGSYYLRQERDGL 305

  Fly   386 LGGNY-----ICVQDS-----------TEEYNSAMIDPQYFAQHIRPHLYNRIPVLGEAQVVDSW 434
            |.|.|     :.:|||           .|.:.|   |......|:...: ..:|||..|.:::..
Zfish   306 LFGPYEREEKMKLQDSWITDGVPAGFGKELFES---DLDRIMDHVEMAM-EMVPVLKNADIINIV 366

  Fly   435 AGCYDHNVYDENGILGAHPYYNNLYLATGFSGHGVQQSLAVGRAISELIMDGQ 487
            :|...:.. |...::|.|....|.:.|.|| |:|:..|..|||.:|:.|::|:
Zfish   367 SGPITYTP-DLLPMIGPHQGARNYWTAIGF-GYGIIHSGGVGRFLSDWIINGE 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Bb	NP_536791.1	DadA	113..501	CDD:223737	87/400 (22%)
dmgdh	XP_021324608.1	DadA	44..433	CDD:223737	97/419 (23%)
		FAO_M	419..466	CDD:318549
		GcvT	466..855	CDD:223481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D752680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920