DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRpL4 and MRPL4

DIOPT Version :9

Sequence 1:	NP_524939.1	Gene:	mRpL4 / 49425	FlyBaseID:	FBgn0001995	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_011526347.1	Gene:	MRPL4 / 51073	HGNCID:	14276	Length:	357	Species:	Homo sapiens

Alignment Length:	253	Identity:	118/253 - (46%)
Similarity:	159/253 - (62%)	Gaps:	16/253 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TSRQVLYPVARTFSRSGNHGNVVTEAAATVGAPPATRSPLILPQDYTDCLPVSRNTARQAWIENT 72
            |..|.|..:|...:|:..:    .|..|:.|.|......:.||      :|..|... |||:|:.
Human    16 TGSQGLSSLAEEAARATEN----PEQVASEGLPEPVLRKVELP------VPTHRRPV-QAWVESL 69

  Fly    73 DAVAERKVGLIELHPDVFAAQPRVDIIQENVEWQSKYRYVSMAHTKTRAEVRGGGRKPWPQKGGG 137
            ....:.:|||.:|||||||..||:||:.:...||..::.:|.|.|||||||||||||||||||.|
Human    70 RGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTG 134

  Fly   138 RARHGSLRSPMLKGGGVVHGPRSPTTHFYMLPFYKRVLGLTSTLSVKLAQDDLHIIDNVDIPTGD 202
            ||||||:|||:.:||||.||||.||:::||||...|.|||...|:||||||||||:|::::||||
Human   135 RARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLELPTGD 199

  Fly   203 AEFLKDLIAERNWGPSVLIVDEDH-MFPANICQASDDLGYVNLMPTFGLNVYSMLKHD 259
            .::|.:|...|.||.|||:||..| ..|.:|.:|:..|...||:|.    |.:..:|:
Human   200 PQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPA----VATRWRHE 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRpL4	NP_524939.1	Ribosomal_L4	83..274	CDD:278970	98/178 (55%)
MRPL4	XP_011526347.1	Ribosomal_L4	81..245	CDD:278970	95/163 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158063
Domainoid	1	1.000	236	1.000	Domainoid score	I2365
eggNOG	1	0.900	-	-		E1_COG0088
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32286
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3112
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52318
OrthoDB	1	1.010	-	-		D1592747at2759
OrthoFinder	1	1.000	-	-		FOG0003002
OrthoInspector	1	1.000	-	-		oto89851
orthoMCL	1	0.900	-	-		OOG6_101056
Panther	1	1.100	-	-	LDO	PTHR10746
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1141
SonicParanoid	1	1.000	-	-		X3343
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800