DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CIAPIN1 and CIAPIN1

DIOPT Version :9

Sequence 1:	NP_524938.1	Gene:	CIAPIN1 / 49424	FlyBaseID:	FBgn0001977	Length:	248	Species:	Drosophila melanogaster
Sequence 2:	NP_064709.2	Gene:	CIAPIN1 / 57019	HGNCID:	28050	Length:	312	Species:	Homo sapiens

Alignment Length:	298	Identity:	116/298 - (38%)
Similarity:	163/298 - (54%)	Gaps:	69/298 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IWTDSADLDK---RVEQLKAATG--GDVALENVHRLSFSSYANSSFDLIV---------IECAQL 63
            :|..|:.::.   .|::|:|.||  |.|::||:.:|..|::..||||:|:         :..|::
Human    15 VWDKSSPVEALKGLVDKLQALTGNEGRVSVENIKQLLQSAHKESSFDIILSGLVPGSTTLHSAEI 79

  Fly    64 TDSYVKLLHMLKPSGKLHLV----------SYIGPAASLLQEIKLSGFINCREDSPDALTAE--- 115
               ..::..:|:|.|.|.|.          |.:..|:.|...:.|||.:..:|...:.||.|
Human    80 ---LAEIARILRPGGCLFLKEPVETAVDNNSKVKTASKLCSALTLSGLVEVKELQREPLTPEEVQ 141

  Fly   116 ---------------------KPGYETGSS--ARLSFAKKNA---------SAVNVWKISGDDEE 148
                                 ||.:|.|||  .:||..||::         :|..:|.:|.:|.|
Human   142 SVREHLGHESDNLLFVQITGKKPNFEVGSSRQLKLSITKKSSPSVKPAVDPAAAKLWTLSANDME 206

  Fly   149 -----LIDEEELLDEEDKQKPDPAGLRV--CSTTGKRKACKNCSCGLAEELETEKQSQKATENAK 206
                 |||.:||||.||.:|||||.||.  |....||||||||:||||||||.||..::.:...|
Human   207 DDSMDLIDSDELLDPEDLKKPDPASLRAASCGEGKKRKACKNCTCGLAEELEKEKSREQMSSQPK 271

  Fly   207 SSCGNCYLGDAFRCSTCPYLGMPAFKPGEKVQLADNLL 244
            |:||||||||||||::|||||||||||||||.|:|:.|
Human   272 SACGNCYLGDAFRCASCPYLGMPAFKPGEKVLLSDSNL 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CIAPIN1	NP_524938.1	CIAPIN1	172..239	CDD:282890	48/66 (73%)
CIAPIN1	NP_064709.2	AdoMet_MTases	3..95	CDD:327401	26/103 (25%)
		N-terminal SAM-like domain. /evidence=ECO:0000255\|HAMAP-Rule:MF_03115	6..172		63/220 (29%)
		Linker. /evidence=ECO:0000255\|HAMAP-Rule:MF_03115	173..224		33/52 (63%)
		Fe-S binding site A. /evidence=ECO:0000255\|HAMAP-Rule:MF_03115	237..251		6/10 (60%)
		CIAPIN1	240..304	CDD:309988	3/7 (43%)
		Fe-S binding site B. /evidence=ECO:0000255\|HAMAP-Rule:MF_03115	274..288
		Cx2C motif 1. /evidence=ECO:0000255\|HAMAP-Rule:MF_03115	274..277
		Cx2C motif 2. /evidence=ECO:0000255\|HAMAP-Rule:MF_03115	285..288

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156522
Domainoid	1	1.000	72	1.000	Domainoid score	I9401
eggNOG	1	0.900	-	-		E1_COG5636
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10658
Inparanoid	1	1.050	180	1.000	Inparanoid score	I4017
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58036
OrthoDB	1	1.010	-	-		D1588798at2759
OrthoFinder	1	1.000	-	-		FOG0004602
OrthoInspector	1	1.000	-	-		oto88325
orthoMCL	1	0.900	-	-		OOG6_102453
Panther	1	1.100	-	-	LDO	PTHR13273
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R350
SonicParanoid	1	1.000	-	-		X3221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800