DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ext2 and sotv

DIOPT Version :9

Sequence 1:	NP_001008400.1	Gene:	ext2 / 493780	ZFINID:	ZDB-GENE-041124-3	Length:	719	Species:	Danio rerio
Sequence 2:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	722	Identity:	345/722 - (47%)
Similarity:	474/722 - (65%)	Gaps:	44/722 - (6%)

- Green bases have known domain annotations that are detailed below.

Zfish    16 PRMKTKHRIYYITLFSVVLLGLIATGMFQFWP----------HSIESSAEWSLDRRSVHDAPLVR 70
            ||   :|.:..:|...:|::.|.|.  |..|.          |....|....||...:.:
  Fly    22 PR---EHILNCLTYGLLVIVALCAG--FLLWDLSSSPRDGFFHGKRDSHTLILDLEHIQE----- 76

Zfish    71 ISVNSPIPGRG-DLSCRMHTCFDVYRCGYNPKNKIKVYIYPLQRFVDEVGVPISSTGLSREYNDL 134
            ::||.....|. :::|....|.::|:|.:   :::||||||||.||||.....::| ||.||..:
  Fly    77 LAVNPEAEQRARNVNCTFWDCLNIYKCEH---DRLKVYIYPLQEFVDEQSDKTATT-LSSEYFQI 137

Zfish   135 LSAISDSDFYTDDVSRACLFVPSIDVLNQNSLRIRETAQALAMLPRWDKGMNHLLFNMLPGGPPD 199
            |.|:..|.:||.:.:.||||:||:|:||||.........|||.|..||:|.||::|||||||.|.
  Fly   138 LEAVLKSRYYTSNPNEACLFLPSLDLLNQNVFDKHLAGAALASLDFWDRGANHIIFNMLPGGAPS 202

Zfish   200 YNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPERQ----PGPRRYFILSSQT 260
            |||.|||..|.|::.||||.:|:||.|:||:|||:||...      ||    ...|::.::.:|.
  Fly   203 YNTVLDVNTDNAIIFGGGFDSWSYRPGFDVAIPVWSPRLV------RQHAHATAQRKFLLVVAQL 261

Zfish   261 AIHREYRVELERLKDENGEALLLLDKCSNLSQGLTSVRKRCYKGQVY---DYPQILQESSFCVVL 322
            .|...:...|..|...:.|.||||..|.||     .:..||...|.:   :||::|....||::.
  Fly   262 NILPRFVRTLRELSLAHSEQLLLLGACENL-----DLTMRCPLSQHHKSLEYPRLLSRGKFCLLG 321

Zfish   323 RGARLGQATLSDVLQAGCVPVIMADSYILPFSEVLDWKRASVVIPEEKLPEMYTILKSIPHRQVE 387
            |..|:||..|.:::...|:|||..|:|:|||.:|:||..|||.|.|.:|..:...||:|...::.
  Fly   322 RSLRMGQPDLVEIMSQHCIPVIAVDNYVLPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIV 386

Zfish   388 EMQRQARWFWEAYFSSMKAIGMTTLQIINDRIYPYAAHTYEEWNNPPVVKWSSVNSPLFLPLIPP 452
            |||:|.:|.:..||..:|.:.:|.|:::..||:|..|.:..:||.......|:.| |||||.:.|
  Fly   387 EMQKQVQWLFSKYFKDLKTVTLTALEVLESRIFPLRARSSRQWNTIDTNARSTFN-PLFLPSLAP 450

Zfish   453 RSPGFTAVVLTYDRIESLFRVITEISKVPSLAKLLVVWNNQNKSPPEESLWPKVAVPLKVVRTKE 517
            :|.|||||:|||||:||||.:|.:::.||||..:||:||||.||||..|.:|.::.|||:.:|||
  Fly   451 KSQGFTAVILTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKE 515

Zfish   518 NKLSNRFFPFDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMGKWK 582
            |||||||:|:.||||||:|.|||||||||:|||.|||||||||||.:||:|.|:|:|::...:|.
  Fly   516 NKLSNRFYPYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWH 580

Zfish   583 YESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANITGKAPIKV 647
            |||||||::|||||||||:|||::::||:.||||||:|||.|||||||||||||||||...||||
  Fly   581 YESEWTNQISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKV 645

Zfish   648 TPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKS 712
            ||||||||||||..:.||.|..||.|||.||::|:.::|.|||:.||.||||||::|:||:|||.
  Fly   646 TPRKKFKCPECTNTEMLSADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFPDKLKR 710

Zfish   713 FPNIGSL 719
            :.:||||
  Fly   711 YNDIGSL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ext2	NP_001008400.1	Exostosin	100..381	CDD:281069	121/287 (42%)
ext2	NP_001008400.1	Glyco_transf_64	457..691	CDD:286358	158/233 (68%)
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	121/289 (42%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	158/233 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592300
Domainoid	1	1.000	373	1.000	Domainoid score	I841
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H345
Inparanoid	1	1.050	680	1.000	Inparanoid score	I685
OMA	1	1.010	-	-		QHG48639
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	1	1.000	-	-		FOG0008338
OrthoInspector	1	1.000	-	-		oto39643
orthoMCL	1	0.900	-	-		OOG6_106435
Panther	1	1.100	-	-	LDO	PTHR11062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4562
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940