DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdc5l and Cdc5

DIOPT Version :9

Sequence 1:	NP_001008202.1	Gene:	cdc5l / 493564	XenbaseID:	XB-GENE-983551	Length:	804	Species:	Xenopus tropicalis
Sequence 2:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	505/817 - (61%)
Similarity:	621/817 - (76%)	Gaps:	39/817 - (4%)

- Green bases have known domain annotations that are detailed below.

Frog     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65

Frog    66 EEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEYLLDKAAQRDNEEESADDPRKLKPGEIDP 130
            ||:||||||||||||||||||||||||||||||.||||||:|.::::.|::.|||||||||||||
  Fly    66 EEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDP 130

Frog   131 NPETKPARPDPVDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAG 195
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||.|||||||||||
  Fly   131 NPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAAG 195

Frog   196 IEIQKKRKKKRGVDYNAEIPFEKKPAPGFYNTSEENYDALNADFRKLRQQDLDGDLRSEKEARDR 260
            |. ...||:.:|:||||||||||:||.|||:||||:......||.|:|||||||:||||||.|:|
  Fly   196 IG-SGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPDFNKMRQQDLDGELRSEKEERER 259

Frog   261 KKDKQNIKRKKESDLPSAILQTTGGVSELTKKRSKLVLPSPQISDAELEEVVKIGQASEIARQTA 325
            |:|||.:|::||:::|:|:||.    .|..:||||||||:|||||.||::|||:|:|||:|::.|
  Fly   260 KRDKQKLKQRKENEVPTAMLQN----MEPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIA 320

Frog   326 EESGITNSASSTLLSEYNVANNSVALRTPKTPAA-QDRILQEAQNLMALTNVDTPLKGGLNTPLH 389
            .||||  ..:..||::|::.....|  ||:|||. .|||:|||||:||||:.:||||||||||||
  Fly   321 GESGI--ETTDALLADYSITPQVAA--TPRTPAPYTDRIMQEAQNMMALTHTETPLKGGLNTPLH 381

Frog   390 ESDFSGVTPQRQVVQTPNTVLSTPFRTPSQSSEGITPRGGMTPK-----PVIGA--------TPG 441
            |||||||.|:...:.|||||::|||||..:.. ..||.|..||.     ||.||        ||.
  Fly   382 ESDFSGVLPKAASIATPNTVIATPFRTQREGG-AATPGGFQTPSSGALVPVKGAGGATGVVNTPA 445

Frog   442 RTPLRDKLNINPEDGTVDYNDPSYIKQMERESREHLRLGLLNLPAPKNDFEIVLPENAERELEER 506
            .  :||||:||||:.......|::.|..:::.:..||.||..||||:||:|||:||..|.|..|.
  Fly   446 Y--VRDKLSINPEESMGVTETPAHYKNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQEESERIET 508

Frog   507 DQDDSFVEDAADIEARKQAIREAQRAKELKNRHNAVQKDLPRPSEVNKTILRPVNVEPPLTDLQK 571
            :.:.: |||.||::||..|.:||:|.:||:.|...:|:.||||:|||..||||.:.:..||:.|:
  Fly   509 NSEPA-VEDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQQ 572

Frog   572 SEEMIKKEMIVMLHYDTIHNPYADNVGGKRGKAPGSAATNAESL-AFLEQSPYDKFSKEELKLAE 635
            :||:||.|||.|..||::.:|           .||.:....|.| ::.:.:||:..|::||..|:
  Fly   573 AEELIKHEMITMQLYDSVKDP-----------VPGQSQHKLEQLQSYFKANPYEDISQQELAKAK 626

Frog   636 DLLQQEMEVVKQGMGHGDLSIDSYNQVWEECYSQVLYLPGQGRYTRANLASKKDRIESLEKRLEI 700
            .:|.:||||||:.|.||:|.:|.|.|||:||..||||||.|.|||||||||||||:||.|||||.
  Fly   627 QMLTEEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTRANLASKKDRLESAEKRLET 691

Frog   701 NRGHMTAEAKRAAKMEKKLKILLGGYQSRAMGLIKQLNEIWDQYEQANLELGTFEELKTHEDIAI 765
            ||.||..||||..|:|||||||.||||:||..|||||.:.:.|.||.::.|.||..|...|.||:
  Fly   692 NRRHMAKEAKRCGKIEKKLKILTGGYQARAQVLIKQLQDTYGQIEQNSVSLSTFRFLGEQEAIAV 756

Frog   766 PRRIECLKEDVQRQEERERELQQRFAELMLEKESYES 802
            |||:|.|:|||:||.:||:||||::|.|:.|::|..|
  Fly   757 PRRLESLQEDVRRQMDREKELQQKYASLVEERDSLYS 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdc5l	NP_001008202.1	REB1	6..>271	CDD:227476	222/264 (84%)
cdc5l	NP_001008202.1	Myb_Cef	405..657	CDD:371749	110/265 (42%)
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	47/47 (100%)
		Myb_DNA-bind_6	11..71	CDD:290632	58/59 (98%)
		SANT_CDC5_II	56..108	CDD:212557	48/51 (94%)
		SANT	60..104	CDD:197842	41/43 (95%)
		Myb_Cef	397..648	CDD:288664	110/265 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	452	1.000	Domainoid score	I502
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13291
Inparanoid	1	1.050	954	1.000	Inparanoid score	I334
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195986at33208
OrthoFinder	1	1.000	-	-		FOG0002438
OrthoInspector	1	1.000	-	-		oto102259
Panther	1	1.100	-	-	LDO	PTHR45885
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R188
SonicParanoid	1	1.000	-	-		X1623
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190