Protein Alignment NVL and Pex1

DIOPT Version :10

• Sequence 1: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Sequence 2: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Alignment Length: 1017
• Identity: 248/1017 - (24%)
• Similarity: 419/1017 - (41%)
• Gaps: 226/1017 - (22%)

Human    25 KCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTE------------ 77
            ||....|:    .:|:.|:......:......:..||:...:..:..:.|.|:
  Fly    82 KCALIADV----LNLRSVHVTPVSSKDWEIIELSTEKISGSVLEQTRIVNSTQILIVWINKSMQV 142

Human    78 -LEDEHLAKRARQGEEDNDVSL-----CHPGF------------SALAQSWLTAVLTSQAQAILP 124
             |..:.|......|..|::..|     .:.|.            :.|::|..||.:..:....|.
  Fly   143 ALTVDRLKPHMNYGRIDHNTELVVAPNLYKGLTNGTSNGVIEENTKLSRSKTTAQVKDELTEKLT 207

Human   125 PQPHRYTESYSDDD---SSMEDYPDPQSANHMNSS--------LLSLYRKGNPDS-----VSNTP 173
            |..|..|.|...:.   :..:|:.:....:....|        :..|:|:...:|     ..:.|
  Fly   208 PLTHSSTVSNVKNTIQRNKRQDHMERLKKDLRRESSRSFEFRVIRGLWREQAQESDVFVNGKHLP 272

Human   174 EMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKT--PSVKKDSFFLDLSCEKSNPK---K 233
            |....:........:.|...:.::|...|.|..  :.:|  ||::.::..:.|...|...:   :
  Fly   273 EFFDLDLFYCMHTAADKDYYVRVRTVEDDIEDD--LPETIHPSIELNANLMKLLGIKELERVVLR 335

Human   234 PITEIQDSKDSSLLESDMKRKGKLKNKGSKR-------------KKEDLQEVDGE---------- 275
            |.|.:.:..:...|.::.|...|:.....||             .:|::..::.:
  Fly   336 PKTTVVNFVEKIELFANKKTHYKIMENAFKRFVIERTQHKPMLFNQEEVVRLEDDLLVTVGILPE 400

Human   276 ------IEAVLQKKAK--ARGLEFQISN-VKFEDVGGNDMTLKEVCKM-----LIHMRHPEVYHH 326
                  ::|...|::|  |..|...:.. :|.|....:.::::::.::     ::.....|:..:
  Fly   401 HFRYCVVDAQFLKESKIYAADLVRPVGEIIKEETPPTSPLSVQDLIQLPEYDKIVDQVVQELRMN 465

Human   327 L------GVVPPRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFD-FSGSNDPPASASQELD 384
            |      .|:....|||.|..|.|||:|...|  .:.......:|.|: |.||..
  Fly   466 LCLSADNSVMRQCNVLLAGASGTGKTVLVERI--LDQLSRKPDYCHFEFFHGSRS---------- 518

Human   385 LPILKVAAPEIVSGVSGESEQK-LRELFEQAVSNAPCIIFIDEIDAIT-PKREVASKDME----- 442
                        .|...||.|| ||.:|...:.:||.|:.::.:|.:. ...|.:|:|.|
  Fly   519 ------------KGRKTESIQKDLRNIFTSCLQHAPAIVVLENLDVLAHAAGEQSSQDGEYYNRM 571

Human   443 ----RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRR-AGRFDREICLGIP--DEAS 500
                .:::.|..|     ||..|     ||...|...:|:..|.. .||...:....:|  :.|.
  Fly   572 ADTVYQLIVQYTT-----NNAIA-----VIATVNELQTLNKRLSSPRGRHVFQTVARLPNLERAD 626

Human   501 RERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEME 565
            ||.||:.||..:.:.:..|....::||.|:...||:.....|...|..  :.|.|.....:..:|
  Fly   627 REIILRELCSHINVAKDLDLVKFSNLTEGYRKCDLVQFVERAIFYAYR--ISKTQPLLTNDQLIE 689

Human   566 DLPS------KGVQ-EERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSS 623
            .|..      :|:| .:|.|.:                .|.:.:..|::.|           |.|
  Fly   690 SLEHTNSYCLQGIQSNQRTGND----------------ADANEMRVEELPG-----------LES 727

Human   624 VQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG 688
            |                   :|.||::       ::.|.|.|..|.|..|...|||||.||||.|
  Fly   728 V-------------------VGVLEEV-------LMWPSRYPTIFNASPLRNQAGVLLYGPPGTG 766

Human   689 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSD 753
            ||.|...:|....|..|||||||||..|:|:||..||.:|.||:::.|||:||||.|:|.|:|..
  Fly   767 KTYLVSQLATSWNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGH 831

Human   754 RETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAI 818
            ..||.:.|||||||||:||:|..|.|.::|||:||:::|||:||.||:|:.:...||....|:.|
  Fly   832 DSTGVTDRVVNQLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRI 896

Human   819 LKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELK 883
            .:.::...:   ||..|:.:..||  :...|||||:.:::..|::.|:::.:|  :.|:||...|
  Fly   897 FEALSSTLS---LDECVDFDWFAG--KTANYTGADIQSILTSANMAAVKEALA--QFGHEKLAKK 954

Human   884 VS--HKHFEEAFKKVRSSISKKDQIMYERL------QESLSR 917
            :|  .||..|:|:..|.|:|..|...|.|.      :|..||
  Fly   955 ISLKQKHLIESFQTTRPSLSASDVAKYHRTYARFTNKEKTSR 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247	7/46 (15%)
		CDC48	<277..917	CDD:273521	198/683 (29%)
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729	10/74 (14%)
		CDC48	365..983	CDD:273521	199/713 (28%)
		RecA-like_PEX1_r2	728..885	CDD:410934	83/182 (46%)