Protein Alignment NVL and Nsf2

DIOPT Version :10

• Sequence 1: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Sequence 2: NP_788676.1
• Gene: Nsf2 / 41694
• FlyBaseID: FBgn0266464
• Length: 752
• Species: Drosophila melanogaster
• Alignment Length: 861
• Identity: 202/861 - (23%)
• Similarity: 340/861 - (39%)
• Gaps: 245/861 - (28%)

Human    95 DVSLCHPGFSALAQSWLTAVLTSQAQAILPPQPHRYTESYSDDDSSMEDYPDPQSANHMNSSLLS 159
            ::.|.|.|||.:.:.|.|..:..:    :..:|:|:..|                     :.:::
  Fly    60 ELPLGHVGFSLVQRKWATLSINQE----IDVRPYRFDAS---------------------ADIIT 99

Human   160 LYRKGNPDSVSNTPEMEQRETTSSTPRISSKT--------GSIPLKTPAKDSEGGWFIDKTPSVK 216
            |        ||...:..|::||:..|..|.:.        ..:||.           :.:|...:
  Fly   100 L--------VSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLT-----------VGQTLVFQ 145

Human   217 -KDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGK-LKNKGSKRKKEDLQEVDGEIEAV 279
             ||..||.|:.:......|.| :.|    ||.::...|.|: |.|...:.:|.:...::
  Fly   146 FKDKKFLGLAVKTLEAVDPRT-VGD----SLPKTRNVRFGRILGNTVVQFEKAENSVLN------ 199

Human   280 LQKKAKARGLEFQISNVKFE----DVGGNDMTLKEVCKMLIHMR--HPEVYHHLGVVPPRGVLLH 338
            ||.::|.:.:...|.|..::    .:||.|.....:.:.....|  .||:...||:...:|:||:
  Fly   200 LQGRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLY 264

Human   339 GPPGCGKTLLAHAIAGAECSGMITAHCSFDFSGSNDPPASASQELDLPILKVAAPEIVSGVSGES 403
            ||||.||||:|..|     ..|:.|         .:|..            |..|:|:....|||
  Fly   265 GPPGTGKTLMARQI-----GTMLNA---------REPKI------------VNGPQILDKYVGES 303

Human   404 EQKLRELFEQA--------VSNAPCIIFIDEIDAITPKR-EVA-SKDMERRIVAQLLTCMD---D 455
            |..:|.||.:|        .::...||..||||||...| .|| :..:...:|.|||..:|   .
  Fly   304 EANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQ 368

Human   456 LNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLR----LPQ 516
            |||      :||||.|||.|.:|.||.|.||.:.::.:.:|:|..|.:||....:::|    :..
  Fly   369 LNN------ILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIAS 427

Human   517 AFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEP 581
            ..|...:|..|..|.||:|..|.|.|...|:||::.                    .:.::..:|
  Fly   428 DVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIK--------------------ADSKVHVDP 472

Human   582 TSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVAL-SSVQPSAKREGFVTVPNVTWADIG 645
                                   |.|:.|.:...||:.|| :.::|:                .|
  Fly   473 -----------------------EAMEKLRVTRADFLHALDNDIKPA----------------FG 498

Human   646 ALEDIREEL------------TMAILAPVRNPDQFKAL---GLVTPAGVLLAGPPGCGKTLLAKA 695
            |.:::.|.|            |..:...:.:..|.||.   |||:   ||:.|.|..||:.||..
  Fly   499 AAQEMLENLLARGIINWGPPVTELLEDGMLSVQQAKATESSGLVS---VLIEGAPNSGKSALAAN 560

Human   696 VANESGLNFISVKGPELLNMYVGESERA----VRQVFQRAKNSAPCVIFFDEVDALC------PR 750
            :|..|...|:.|..||.:   ||.:|.|    :|::|..|..|....|..|.|:.|.      ||
  Fly   561 LAQLSDFPFVKVCSPEDM---VGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERLLDYGPIGPR 622

Human   751 RSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR 815
            .|:    .:::.:..||.:..  ...:::.|:..::|.|:::...:............|..|.:.
  Fly   623 YSN----LTLQALLVLLKKQP--PKGRKLLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENV 681

Human   816 LAILKTITKNGTKPPLDADV----NLEAIAGDLRCDCYTGADLSALVRE--ASICALRQEMARQK 874
            ||:|.           |:|:    .|::||..:     .|..|...:::  |.|..:||....|:
  Fly   682 LAVLD-----------DSDLFSPEELQSIARKM-----AGKRLCIGIKKLLALIDMIRQSEPHQR 730

Human   875 ------SGNEKGELKV 884
                  ...|:|.|::
  Fly   731 VIKFLSKMEEEGGLEM 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247
		CDC48	<277..917	CDD:273521	166/669 (25%)
Nsf2	NP_788676.1	CDC48_N	9..89	CDD:215012	7/32 (22%)
		CDC48_2	117..>170	CDD:215011	13/68 (19%)
		RecA-like_NSF-SEC18_r1-like	224..400	CDD:410912	68/207 (33%)
		CDC48	<225..>611	CDD:273521	131/482 (27%)