Protein Alignment NVL and CG14183

DIOPT Version :10

• Sequence 1: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Sequence 2: NP_649172.3
• Gene: CG14183 / 40192
• FlyBaseID: FBgn0036931
• Length: 872
• Species: Drosophila melanogaster
• Alignment Length: 951
• Identity: 172/951 - (18%)
• Similarity: 326/951 - (34%)
• Gaps: 276/951 - (29%)

Human    11 NKLK------QRVIQYLTSNKCGKYVDIGV----LASDLQRVYSIDYGRRKRNAFRIQVEKVF-S 64
            |:||      ::.:.|..      |.::.|    |.:.|..:|...:..:||...|:.||... .
  Fly    25 NRLKKIEPPEEKAVSYKI------YAELYVLYVELVNKLSFIYHNTFQVQKRALVRVLVENATQQ 83

Human    65 IISSEKELKNLTELEDEHLAKRARQGEEDNDVSLCHPGFSALAQSWLTA--VLTSQAQAILPPQP 127
            ::..::|||:|...|..::.|                   ||....||.  ::..::...|..:|
  Fly    84 LMQLKEELKDLEMSEYIYIDK-------------------ALIARKLTPRDLVVWRSPQFLYRRP 129

Human   128 HRYTESYSDDDSSMEDYPDPQSA---------------NHMNSSLLSLYRKGNPDSVSNTPEMEQ 177
            .......:|:...|.|....:.|               .|..:....:|:...........::.|
  Fly   130 LDIQNIIADNRLYMNDEEKEEKAAQDWVPISEAVKLIQAHERARRARVYKSNIKYDKKKFLKVHQ 194

Human   178 RETTSSTPRISSK-------TGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFL--DLSCEKSNPKK 233
            |:      :|:.|       ..|||:|.....::                ||  |.|||....|.
  Fly   195 RK------KINYKFTFKPDQAMSIPVKRTIFSAD----------------FLKADESCENLIKKD 237

Human   234 PI--TEIQDSKDSSLLESDMKRK------GKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLE 290
            .:  |.|.|.:..|.::::...|      |....|..|.:|...:|:.|      .||.:.....
  Fly   238 DVADTAIDDEEALSAIQNNAACKIQSCWRGYKTRKIVKIRKRFKEELYG------MKKIRKLKRP 296

Human   291 FQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGA 355
            .|.:| ...::..|:|..|::.:..|::.:.|                      :|.|
  Fly   297 NQTAN-SIMEMYKNEMLKKKLDEDFINLINDE----------------------RTRL------- 331

Human   356 ECSGMITAHCSFDFSGSNDPPASASQELDLPILKVAAPEIVSGVSGESEQKLRELFE-------- 412
                                            |:..:|.::..:|.......:|.::
  Fly   332 --------------------------------LQFRSPWMMEDISDHIRAWFKEFYDATGNFHPY 364

Human   413 -QAVSNAPCIIFIDEIDAITP-------------KREVAS-KDMERRIVAQLLTCMDDLNNVAAT 462
             ..|.....::.|||  .:||             |.|:.. :|.|::...:....:..|....|.
  Fly   365 PDPVKQGTVLVVIDE--TMTPMEFQESLGKKPLSKAELKKLRDKEKKEKRKKKEKLKQLKMKEAK 427

Human   463 AR-------VLVIG----ATNRPDSLDPALRRAGRFDREI--CLGIPDEASRERILQTLCRKLRL 514
            .|       |:.||    |:...::::..:::..:..|.:  .|....:..:|.:.:....|:..
  Fly   428 RRKKLRDAGVIDIGYELTASKAIENIEETMKKYSKDWRNVDEYLNKNHDPIKEWVTEEQLAKIHQ 492

Human   515 PQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGT 579
                   .:..|...::..: ..|.|||        |.|..:::.|..::: .|.|  ::|:...
  Fly   493 -------EVRGLVDEYMRVE-YELLREA--------LAKDNDEKYKALKVK-YPKK--KKEKRKK 538

Human   580 EPTSETQDE-LQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWAD 643
            :|...|.|. |:.|...|:|...:.|       |...||             :.|:|..|.
  Fly   539 KPKDMTGDRTLESLYNELKDAGIIEE-------IGHRDF-------------DEFITDFNF---- 579

Human   644 IGALEDIREELTMAILAP----VRNPDQFKALGL-----VTPAGVLLAGPPGCGKTLLAKAVANE 699
              ..:|.|:|..:..|.|    ::...|...||:     ..|..:||.||...||.||.:.:|:|
  Fly   580 --VADDTRDEDGLTTLGPAKGDIKMVIQESMLGMGEFDVPKPKSLLLIGPLNSGKRLLCEIIASE 642

Human   700 SGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVN 764
            ....|::: .||....|..:.:..:..:.:.||...|.:::.:|...|..::...|   :|.:..
  Fly   643 LDAVFMNL-SPENTYKYAKDLKYFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPE---AVEINP 703

Human   765 QLLTE------MDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR----LAIL 819
            :||..      :..|:...::.::..:|.|...:..|.|  ...|.|.:   |..|.    |..|
  Fly   704 RLLGTSLASKILKPLKKNDKIVLVGTSNMPWAANGGIKR--AFQKVLLI---PKCDYGTSFLLWL 763

Human   820 KTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVRE 860
            :.:|:|.  |....:....|:|..|:  .|...|:...|:|
  Fly   764 ELMTENA--PDDMKEYAYSALARVLQ--AYNSGDIDDNVKE 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247	14/71 (20%)
		CDC48	<277..917	CDD:273521	114/640 (18%)
CG14183	NP_649172.3	Adgb_C_mid-like	<201..>278	CDD:412094	20/92 (22%)
		globin helix H	201..232	CDD:412094	10/46 (22%)
		IQCD	247..278	CDD:467745	5/30 (17%)
		IQ motif	259..277	CDD:412094	4/17 (24%)
		P-loop containing Nucleoside Triphosphate Hydrolases	617..750	CDD:476819	31/138 (22%)