Protein Alignment NVL and CG5776

DIOPT Version :10

• Sequence 1: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Sequence 2: NP_609585.1
• Gene: CG5776 / 34680
• FlyBaseID: FBgn0032450
• Length: 799
• Species: Drosophila melanogaster
• Alignment Length: 719
• Identity: 233/719 - (32%)
• Similarity: 363/719 - (50%)
• Gaps: 152/719 - (21%)

Human   237 EIQDSKDSSLLESDMKRKGKLK---------NKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEF- 291
            ::||:  .:||:.||..:...|         ||....:.|..|....|..|.|...:|.  |:|
  Fly   181 QLQDA--IALLKRDMVNRVFYKDSLIHMNFFNKSLTFRLERWQSTVEEALAGLSLDSKP--LQFI 241

Human   292 QISNV-----------------KFE------DVGGNDMTLKEVCKMLIHMRHPEVYHHL--GVVP 331
            |::||                 |..      .:||.|..|:.|.:   .|.:...:..|  |:..
  Fly   242 QVTNVTKLHLITDDANQQEEEQKISHRITKCQIGGLDRQLQLVEE---SMEYALGFRTLPAGLRV 303

Human   332 PRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFDFSGSNDPPASASQELDLPILKVAAPEIV 396
            .||:||:|..||||:::..|:...                     |....:..:.::::.:.|:.
  Fly   304 SRGLLLYGATGCGKSMVLEAMCAV---------------------AEERSQGHVQLIRINSGEVY 347

Human   397 SGVSGESEQKLRELFEQAVSN--APCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNV 459
            |...||:||||..:||:|.::  .|.::.|:::..:.||:|  :.|:.:|:....|:.:|.|::.
  Fly   348 SKFLGETEQKLGAIFERAYNHYPHPTLLLIEDVHNLCPKQE--NSDLVKRVSLAFLSLLDQLSSP 410

Human   460 AAT--ARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFD--F 520
            :..  ::..|:..:::.|:|.|::|||||.|.|:.||.|...:|..|::.|.:.:. .|..|  .
  Fly   411 SQLKGSKTFVLATSSQIDTLHPSIRRAGRLDNEVELGAPSSQARLEIVRCLIKSVE-HQLSDEEV 474

Human   521 CHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSET 585
            .|:|.:|.|:|||||..|. .|||         ||.|
  Fly   475 EHVASITHGYVGADLANLV-YAAM---------LQAQ---------------------------- 501

Human   586 QDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDI 650
                         .:||....:|          .||:.::|||.||..:..|||.|:|||...::
  Fly   502 -------------PNPLQMPHLQ----------AALTRIKPSAMREVLIECPNVQWSDIGGQSEL 543

Human   651 REELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM 715
            |..:..||..|:.:.|:|:.||:..|.|:|:.|||||.||::|||:|.||.|||:|:|||||.:|
  Fly   544 RLAMQQAIEWPLLHADKFQRLGIKPPRGILMFGPPGCSKTMIAKALATESKLNFLSIKGPELFSM 608

Human   716 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRE---TGASV--RVVNQLLTEMDGLEA 775
            :|||||||||:||::|:..||.::||||:||:...||:.:   :|:||  ||:.|||||:||:||
  Fly   609 WVGESERAVREVFRKARQVAPAIVFFDEIDAIGGERSEGDGSSSGSSVKERVLTQLLTELDGVEA 673

Human   776 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAI 840
            .|.|.|:|||||||:||.|:|||||:|:.|:||||....|..|||...:   ..|:..||::|.:
  Fly   674 LQNVTIVAATNRPDMIDKALLRPGRIDRILYVGLPQCEARREILKIKLR---AMPISNDVDMEKL 735

Human   841 AGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQ 905
            .  ...:.|:||::.|:..||::.||.|....:         .|....||.|.|.|....|.:..
  Fly   736 V--QLTEGYSGAEIQAVCHEAALRALEQSFEAE---------DVKWTDFEHALKAVPPRTSPELL 789

Human   906 IMYE 909
            .:||
  Fly   790 KLYE 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247
		CDC48	<277..917	CDD:273521	221/670 (33%)
CG5776	NP_609585.1	CDC48	183..797	CDD:273521	233/717 (32%)