Protein Alignment NVL and Fign

DIOPT Version :10

• Sequence 1: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Sequence 2: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 129/487 - (26%)
• Similarity: 218/487 - (44%)
• Gaps: 84/487 - (17%)

Human   497 DEASRERILQTLCRKLRLPQA-------FDFCHLAHLTP---GF---------VGADLMALCRE- 541
            ::|.:||..:.:....|..:.       |:..|.:...|   ||         ..:||.|...|
  Fly    45 EKAMKERCQKKITMSRRTKRGITHAGYLFEMPHNSVFEPECRGFYESCQQTEMASSDLQAPALEV 109

Human   542 AAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSET------------QDELQRLLG 594
            ::...|.:.:....|.|  .||..:..:|.:..::..:|.:|::            .|||::
  Fly   110 SSTYPVQQAVKSRPEGQ--FPESRNNSTKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKK--- 169

Human   595 LLRDQDPLSE-------------EQMQGLCIELNDFIVAL-----------SSVQPSAKR----- 630
              :::...||             :.:.|.....::|:..:           ||:.|:...
  Fly   170 --KNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSIPPALAHLDSKM 232

Human   631 ------EGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGK 689
                  |.......|.|.||..||..:.....||:.|:|.||.|..: ...|.||||.||||.||
  Fly   233 VDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGV-RCPPRGVLLFGPPGTGK 296

Human   690 TLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDR 754
            ||:||::|:::...|.|:....|.:.:||::|:.|:.:|..|....|.:||.||||:|..:||..
  Fly   297 TLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSAN 361

Human   755 ETGASVRVVNQLLTEMDGLEARQQ--VFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLA 817
            |..:::|:.|:.|..:||..:.::  |.::.|||||..:|.|:.|  |..:.|:|.||....|..
  Fly   362 ENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRR--RFVRRLYVPLPTREARQK 424

Human   818 ILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGEL 882
            |::.:. :..|..||....:|  ..:| .|.|:|||:..|.|.||:..||.....|....|..:|
  Fly   425 IIEKLI-HQVKHNLDVRQVIE--LAEL-TDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQL 485

Human   883 -KVSHKHFEEAFKKVRSSISKKDQIMYERLQE 913
             .|:...|::|.:.:..|:|.:|...:|...|
  Fly   486 PAVTMDDFKQALRVISKSVSSEDCKQFEAWNE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247
		CDC48	<277..917	CDD:273521	129/487 (26%)
Fign	NP_608763.2	PH-like	<4..50	CDD:473070	1/4 (25%)
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	66/187 (35%)
		AAA_lid_3	444..495	CDD:465537	18/53 (34%)
		Vps4_C	<480..520	CDD:462762	10/38 (26%)