DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP2B4 and PMCA

DIOPT Version :9

Sequence 1:	NP_001675.3	Gene:	ATP2B4 / 493	HGNCID:	817	Length:	1205	Species:	Homo sapiens
Sequence 2:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster

Alignment Length:	1246	Identity:	735/1246 - (58%)
Similarity:	894/1246 - (71%)	Gaps:	85/1246 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    16 ESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNPADLEKRRQVF 80
            :.|...:|.::.:||:|||.|.|:.:.:| ...||:..||.:|.|||.|||||:.||.|.||:.|
  Fly     5 DGRPAQYGISLKQLRELMEHRGREGVMKI-AENGGIHELCKKLYTSPNEGLSGSKADEEHRRETF 68

Human    81 GHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEA 145
            |.||||||.|||||.|||||||||||||||:||::||.||||:||.|:..:.        .|.|.
  Fly    69 GSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVL--------QEEEE 125

Human   146 QAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGD 210
            ..|||||.|||.|||:||:||||||:|||:||||||.|||.|.|||:||.|::.|:.|.:|:|||
  Fly   126 HHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGD 190

Human   211 IAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVG 275
            ||||||||||||||.|||.||||:||||||||||||||..|.|||:|||||||||||:|||||||
  Fly   191 IAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVG 255

Human   276 VNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKT--QDGVALEI---QPLNSQEGIDNE 335
            ||||.|||.||||...|::..:.||.||:....|:.|..|  .||.: :|   |..:.:|.:.:|
  Fly   256 VNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRS-QIKGSQAPSQRETVTSE 319

Human   336 --EKDKKAVKVP------------KKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDN 386
              :.:.:...:|            ||||||||.|||:||:|||.||..::.|||.|||:.|.|..
  Fly   320 ITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKT 384

Human   387 FVINRRPWLPECTPIYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 451
            |||:.:||    ...|....||..|||:||||||||||||||||:||||||||||||||||||||
  Fly   385 FVIDEKPW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLD 445

Human   452 ACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTS 516
            ||||||||||||||||||||.|||||||:||.....:.:|:.......|.:||..|||:||||||
  Fly   446 ACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTS 510

Human   517 KILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRN 581
            .|:.....|.||.||||||||||||||..|...||::|:|:.|:|..:|||||||||||.|||..
  Fly   511 NIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPR 575

Human   582 PNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDF- 645
            ||||:|:|:|||||||::||..|...:|....|....::.::|.|||||||||||||.:|||||
  Fly   576 PNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFV 640

Human   646 ----------DDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNI 700
                      .|.||:||:|..|:|.|||:.||||||||||||||||.||::|||||||||||||
  Fly   641 PGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNI 705

Human   701 NTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLV 765
            ||||:||:|||||.|.||||.||||||||.||:..|:::|..:||:|||||||||||||||:|||
  Fly   706 NTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLV 770

Human   766 KGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAV 830
            ||||||||.|:|:|||||||||||||||||||||||||||||||||||||||||||||:||||||
  Fly   771 KGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAV 835

Human   831 MWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPP 895
            ||||||||||:||||||||||||||||||.|||..|||||||||||||||||||.||||||||.|
  Fly   836 MWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFP 900

Human   896 TESLLKRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHY 960
            |..||.|:||||.||||||||||||||.|.||||:||.|:|.|:...||:|||...|::.|:||:
  Fly   901 TPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHF 965

Human   961 TIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLS 1025
            ||:|||||:|.||||||:|||||::||..|:..|.||.::.:.|.|.|:.|:::|...||..:|:
  Fly   966 TIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALT 1030

Human  1026 LSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKE---EITKDAEGLDEIDHAEMELR 1087
            |.|||||:|.|||.|:|||.|:::|||.|..:...|.|..:|   .:....|..|.|| ::.:.|
  Fly  1031 LDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSID-SDKKPR 1094

Human  1088 RGQILWFRGLNRIQTQIKVVKAFHSSLHESIQKPYNQKSIHSFMT------------HPEF---- 1136
            .|||||.|||.|:|||::|::||.|:| |.:.:..:..|:||..:            ||.:
  Fly  1095 AGQILWIRGLTRLQTQLRVIRAFRSTL-EDLNERRSMHSLHSLRSPRTGIPVAVGGGHPLYNFNL 1158

Human  1137 ----AIEEELPRTPLLDEEEEEN-------PDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQ 1190
                .|:.:..:.|.|..:.:.|       ||        :..:|.:......|.:|.:...:..
  Fly  1159 LNPNYIKHQQQQEPKLPPQTQLNVSSGMMSPD--------ISYIDEDPQQQQRTLHNGLTSQRSS 1215

Human  1191 LPQS-DSSLQS 1200
            :|.: .||.||
  Fly  1216 MPSNVPSSNQS 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP2B4	NP_001675.3	ATPase-IIB_Ca	20..1052	CDD:273668	686/1061 (65%)
ATP2B4	NP_001675.3	ATP_Ca_trans_C	1089..1135	CDD:403580	22/57 (39%)
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	687/1065 (65%)
		Cation_ATPase_N	36..104	CDD:279080	48/67 (72%)
		E1-E2_ATPase	172..448	CDD:278548	166/280 (59%)
		Cation_ATPase	505..598	CDD:289987	60/92 (65%)
		HAD_like	676..807	CDD:119389	107/130 (82%)
		Cation_ATPase_C	873..1051	CDD:279079	114/177 (64%)
		ATP_Ca_trans_C	1096..1142	CDD:289209	21/46 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158219
Domainoid	1	1.000	256	1.000	Domainoid score	I2040
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1374	1.000	Inparanoid score	I126
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm40424
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R99
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800