Protein Alignment SERCA and ATP2C2

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001273456.2
• Gene: ATP2C2 / 9914
• HGNCID: 29103
• Length: 975
• Species: Homo sapiens
• Alignment Length: 1020
• Identity: 331/1020 - (32%)
• Similarity: 499/1020 - (48%)
• Gaps: 182/1020 - (17%)

  Fly    16 FGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEE 80
            |..|...||:...:...:..:|.||...:..:.:|:..|:||.:.|:.:||.:|::|   .|.:|
Human    69 FCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVS---VLTKE 130

  Fly    81 HEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEI 145
            :|:..:.....||::       .|...||..:|.::|.|.:..|.....:|:.|  :|.:.|:|:
Human   131 YEDAVSIATAVLVVV-------TVAFIQEYRSEKSLEELTKLVPPECNCLREGK--LQHLLAREL 186

  Fly   146 VPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQD---KKNI 207
            ||||:|.:|:||:||||||:|.:  |.|.:|:|..|||:....| ||:   |.....|   ..||
Human   187 VPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSK-TDS---PLTGGGDLTTLSNI 245

  Fly   208 LFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS----KVISVIC 268
            :|.||.|..|:.:|||||||.|:..|::...|...|..|||||:.:|..|:||:    .:|.:|.
Human   246 VFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIM 310

  Fly   269 VAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIV 333
            :..|              |..|..:..|.|.|:|||||||||||.|:...|.||..|||||..||
Human   311 LIGW--------------SQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIV 361

  Fly   334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVFLN 398
            :.||.||||||.||:|||||||||.|:|:|:::...|.        |..|::|..|:..|.|.|.
Human   362 KKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDG--------LRAEVSGVGYDGQGTVCLL 418

  Fly   399 GQRIKAADYDTLQELSTICI--------MCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455
            ..:      :.::|.|.:.:        :.|::.|..|..      :|:.||.||:.||.|::..
Human   419 PSK------EVIKEFSNVSVGKLVEAGCVANNAVIRKNAV------MGQPTEGALMALAMKMDLS 471

  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPK---LFVKGA 517
            .:..|.:.                |||  :.||.::|.|:..|:      |.|..:   .|:|||
Human   472 DIKNSYIR----------------KKE--IPFSSEQKWMAVKCS------LKTEDQEDIYFMKGA 512

  Fly   518 PEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDST 582
            .|.|:..||....|...:|||...::..|....:.|    :|....||:|..|      :||
Human   513 LEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMG----SLGLRVLALASGP------ELG--- 564

  Fly   583 KFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDED 647
                   .|||:|:||::||||..|.:::.....:|:.|.:||||...||.||.|.||:
Human   565 -------RLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGL------ 616

  Fly   648 TTGK--SYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPA 710
            ..||  :.||.|.|.:...|....|.:..:|.|..|:||.||::.||....|.||||||||||.|
Human   617 CNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVA 681

  Fly   711 LKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVS 774
            ||.|:|||||| :||.|:|.||.|:|.||:||:|::|||||:.|:.|:|.|:|:.:|::|..:..
Human   682 LKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSL 746

  Fly   775 IFLTAALGLPEALIPVQLLWVNLVTDGLPA-----------------------------TALGFN 810
            |.|:....||..|..:|:||:|::.||.||                             ..||..
Human   747 ITLSTVFNLPSPLNAMQILWINIIMDGPPAQRSSQKTEVCCTAVRLGVEGRGESTWAGRAGLGVE 811

  Fly   811 PPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLS 875
            |.|.|...:|||...:.::|..|..:.:.....:.:.|:      |:|..|.|:
Human   812 PVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTL------FIFWKEMPE----------- 859

  Fly   876 CLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALS 940
                 |.        .|.|...||..:..|..::.||:...|:.:.:..:....|...:.|:..|
Human   860 -----DR--------ASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGS 911

  Fly   941 FTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLK 985
            ......::|:..|..|||...|.|.:.:.:...:..|.:|.|.||
Human   912 ILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLK 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	331/1020 (32%)
ATP2C2	NP_001273456.2	ATPase-IIA2_Ca	55..960	CDD:130585	331/1020 (32%)
		Cation_ATPase_N	63..125	CDD:279080	15/55 (27%)
		E1-E2_ATPase	149..368	CDD:278548	97/240 (40%)
		Cation_ATPase	441..523	CDD:289987	30/111 (27%)
		COG4087	<625..709	CDD:226572	44/83 (53%)
		Cation_ATPase_C	756..957	CDD:279079	49/231 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730