Protein Alignment SERCA and PMA2

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_015289.1
• Gene: PMA2 / 856071
• SGDID: S000005957
• Length: 947
• Species: Saccharomyces cerevisiae
• Alignment Length: 1001
• Identity: 254/1001 - (25%)
• Similarity: 407/1001 - (40%)
• Gaps: 251/1001 - (25%)

  Fly     4 GHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILL-L 67
            |.....|:.|:   |||..|||.|::...:||||.|:: .||.:|           |:||.|: .
Yeast   100 GQRVVPEKDLS---TDPAYGLTSDEVARRRKKYGLNQM-AEENES-----------LIVKFLMFF 149

  Fly    68 AAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQ 132
            ...|.||:..........:.:|:..||..:|:.||.||..||..|.|.::.||:.......|:|.
Yeast   150 VGPIQFVMEAAAILAAGLSDWVDVGVICALLLLNASVGFIQEFQAGSIVDELKKTLANTATVIRD 214

  Fly   133 DKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDP 197
            .:  :.::.|.|:|||:::::..|...|||.||. .....|:||||.:||||::..||..
Yeast   215 GQ--LIEIPANEVVPGEILQLESGTIAPADGRIV-TEDCFLQIDQSAITGESLAAEKHYG----- 271

  Fly   198 RAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSK 262
                    :.:||.:.|..|:|..||..||.:|.:|:....:.:...::....:.|:..|..|..
Yeast   272 --------DEVFSSSTVKTGEAFMVVTATGDNTFVGRAAALVGQASGVEGHFTEVLNGIGIILLV 328

  Fly   263 VISVICVAVWAINIGHFNDPAHGGSWIKGAIYY--------FKIAVALAVAAIPEGLPAVITTCL 319
            ::....:.||.                  |.:|        .:..:.:.:..:|.|||||:||.:
Yeast   329 LVIATLLLVWT------------------ACFYRTVGIVSILRYTLGITIIGVPVGLPAVVTTTM 375

  Fly   320 ALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGND---SSFLE 381
            |:|...:|||.|||:.|.::|:|....::|||||||||.|::|:...:..:.|..:|   ::.|.
Yeast   376 AVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVSPDDLMLTACLA 440

  Fly   382 FEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALI 446
            ........:.|.:.||.                        |.|:|.:.|.|.
Yeast   441 ASRKKKGLDAIDKAFLK------------------------SLIEYPKAKDAL------------ 469

  Fly   447 VLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLE---FSRDRKSMSSYCTPLKASRLGT 508
                                          ||:|   .||   |....|.:::.....:..|:
Yeast   470 ------------------------------TKYK---VLEFHPFDPVSKKVTAVVESPEGERI-- 499

  Fly   509 GPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKP 573
               :.|||||..||:...........|......|...||..|        .|.|.:|
Yeast   500 ---VCVKGAPLFVLKTVEEDHPIPEDVHENYENKVAELASRG--------FRALGVA-------- 545

  Fly   574 DEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRR 638
              ...|:.    .:|:    :||:..:||||.:...:|...|..|:|:.::|||....|:..||:
Yeast   546 --RKRGEG----HWEI----LGVMPCMDPPRDDTAQTINEARNLGLRIKMLTGDAVGIAKETCRQ 600

  Fly   639 IGVFAE--DEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMT 701
            :|:...  :.:..|....|    |:..:|....|..:..|:.|.||||.::||.||:...:.|||
Yeast   601 LGLGTNIYNAERLGLGGGG----DMPGSELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMT 661

  Fly   702 GDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLIS 766
            ||||||||:||||:.|||:...|..|:|||::|......|:|:.|::..|.|::.|..::.|.|:
Yeast   662 GDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIA 726

  Fly   767 SNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISG 831
                  :|:.|...||          ||:.::.:.|....:.|
Yeast   727 ------LSLHLEIFLG----------LWIAILNNSLDINLIVF---------------------- 753

  Fly   832 WLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHA 896
                    |..:...||:..|   :..:...|:...|.|..    |.|.....|:...|.|....
Yeast   754 --------IAIFADVATLTIA---YDNAPYAPEPVKWNLPR----LWGMSIILGIVLAIGSWITL 803

  Fly   897 MTMALSVLVTIEMLNAMN-------SLSENQSLITMPPWCNLWLI---------GSMALSFTLHF 945
            .||.|.....|:...|||       ||:||            |||         .|...|:.|..
Yeast   804 TTMFLPNGGIIQNFGAMNGVMFLQISLTEN------------WLIFVTRAAGPFWSSIPSWQLAG 856

  Fly   946 VILYVDVLSTVFQVTPLSAEEWITVM 971
            .:..||:::|:|.:....:|.|..::
Yeast   857 AVFAVDIIATMFTLFGWWSENWTDIV 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	253/1000 (25%)
PMA2	NP_015289.1	P-type_ATPase_H	116..903	CDD:319771	248/982 (25%)