DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and PMR1

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_011348.1	Gene:	PMR1 / 852709	SGDID:	S000003135	Length:	950	Species:	Saccharomyces cerevisiae

Alignment Length:	1022	Identity:	319/1022 - (31%)
Similarity:	520/1022 - (50%)	Gaps:	146/1022 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVEQSLNFFGTDPERGLTLDQIKANQKK--YGPNELPTEEGKSIWQLVLEQF-DDLLVKILLLAA 69
            :|:::|....||...||.... :||.::  |||||:..|:.:|:::..|..| :|.::.:|:.:|
Yeast    42 SVDEALEKLDTDKNGGLRSSN-EANNRRSLYGPNEITVEDDESLFKKFLSNFIEDRMILLLIGSA 105

  Fly    70 IISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDK 134
            ::|..:...:          :.:.|.|.:.....||..||..:|.::|||.:..|....::|..:
Yeast   106 VVSLFMGNID----------DAVSITLAIFIVVTVGFVQEYRSEKSLEALNKLVPAECHLMRCGQ 160

  Fly   135 SGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAI----- 194
            .  ..|.|..:||||||...:||:|||||||  |.:..|.||:|.||||:..|.|.:..|
Yeast   161 E--SHVLASTLVPGDLVHFRIGDRIPADIRI--IEAIDLSIDESNLTGENEPVHKTSQTIEKSSF 221

  Fly   195 ---PDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEF 256
               |:......::..|.:.||.|..|..:|:|:|||.:|:.|.:...|:..|:.|||||..:|:.
Yeast   222 NDQPNSIVPISERSCIAYMGTLVKEGHGKGIVVGTGTNTSFGAVFEMMNNIEKPKTPLQLTMDKL 286

  Fly   257 GEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLAL 321
            |:.||.|..::...:..:.|      ..|.||::    .|:|:|:|||||||||||.::|..|||
Yeast   287 GKDLSLVSFIVIGMICLVGI------IQGRSWLE----MFQISVSLAVAAIPEGLPIIVTVTLAL 341

  Fly   322 GTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTG 386
            |..||||:.||||.||||||||..:|||||||||||:|.|:||:::..|.: .|..:.|..:...
Yeast   342 GVLRMAKRKAIVRRLPSVETLGSVNVICSDKTGTLTSNHMTVSKLWCLDSM-SNKLNVLSLDKNK 405

  Fly   387 STYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEK 451
            .|....|       .:|....:.::|..||..:||:::  :::....|  :|..|:.||:   |:
Yeast   406 KTKNSNG-------NLKNYLTEDVRETLTIGNLCNNAS--FSQEHAIF--LGNPTDVALL---EQ 456

  Fly   452 LNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMS--------SYCTPLKASRLGT 508
            |.:|.:               .:|....:|...|.|:..||.|:        :.||
Yeast   457 LANFEM---------------PDIRNTVQKVQELPFNSKRKLMATKILNPVDNKCT--------- 497

  Fly   509 GPKLFVKGAPEGVLERCTH--ARVGTTKVPLTSALKAKI------LALTG--QYGTGRDTLRCLA 563
               ::||||.|.:||..|.  ...|.....||.|.||.|      :|..|  .:|..:     |.
Yeast   498 ---VYVKGAFERILEYSTSYLKSKGKKTEKLTEAQKATINECANSMASEGLRVFGFAK-----LT 554

  Fly   564 LAVADSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDN 628
            |:.:.:|:..|.:.            :|||.|::||.||||..|..:|.:....|:.:|:||||:
Yeast   555 LSDSSTPLTEDLIK------------DLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITGDS 607

  Fly   629 KATAEAICRRIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQS 693
            :.||..|.::||:...|...:  ..||.:.|::|..:....:....:|:|..|:||..||..|:.
Yeast   608 ENTAVNIAKQIGIPVIDPKLS--VLSGDKLDEMSDDQLANVIDHVNIFARATPEHKLNIVRALRK 670

  Fly   694 MNEISAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNM 757
            ..::.||||||||||||||.::||::||. ||.|||.|::|||.||:||:|::|:|||:.|:||:
Yeast   671 RGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFSTILTAIEEGKGIFNNI 735

  Fly   758 KQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPR 822
            :.|:.:.:|:::..:..:.|:.|..||..|..:|:||:|::.||.||.:||..|.|.::|:||||
Yeast   736 QNFLTFQLSTSVAALSLVALSTAFKLPNPLNAMQILWINILMDGPPAQSLGVEPVDHEVMKKPPR 800

  Fly   823 KADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVD 887
            |..:.:::..:..|.:.....:...||      ::|..|                      ...|
Yeast   801 KRTDKILTHDVMKRLLTTAACIIVGTV------YIFVKE----------------------MAED 837

  Fly   888 CKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDV 952
            .|:.:  ...||..:..|..:|.||:......:|:..:..:.|.....::.||.......:|:..
Yeast   838 GKVTA--RDTTMTFTCFVFFDMFNALACRHNTKSIFEIGFFTNKMFNYAVGLSLLGQMCAIYIPF 900

  Fly   953 LSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADGESPIY 999
            ..::|:...|...:.:.::..|..|.::||..|...||..:.:|..:
Yeast   901 FQSIFKTEKLGISDILLLLLISSSVFIVDELRKLWTRKKNEEDSTYF 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	316/1010 (31%)
PMR1	NP_011348.1	ATPase-IIA2_Ca	35..940	CDD:130585	318/1013 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720