DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and ENA2

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_010324.3	Gene:	ENA2 / 851609	SGDID:	S000002446	Length:	1091	Species:	Saccharomyces cerevisiae

Alignment Length:	1083	Identity:	289/1083 - (26%)
Similarity:	497/1083 - (45%)	Gaps:	178/1083 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAA 69
            |:.|.|::..|.||....|||.|:.....|..|.|.|..:.......:||.|..:.::.:|:::.
Yeast    18 HTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNAMIMVLVISM 82

  Fly    70 IISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDK 134
            .|||.:          ..::...||..::..|.::|:.||..|...:.:||........|:|..|
Yeast    83 AISFAV----------RDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIRNGK 137

  Fly   135 SGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAI---PD 196
            |  :.:.:|::||||:..|.|||.||||:|:  |.:.....|:|:|||||:.|.|..:.:   .:
Yeast   138 S--ETINSKDVVPGDICLVKVGDTIPADLRL--IETKNFDTDESLLTGESLPVSKDANLVFGKEE 198

  Fly   197 PRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMS--------------------E 241
            ..:|. |:.|:.||.:.|..|:|:|:||.|.|::.||||...:.                    .
Yeast   199 ETSVG-DRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWIS 262

  Fly   242 TEEIK---------TPLQQKLDEFGEQL---SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIY 294
            |:::.         |||.:||.:....|   :.:.::|.:|....::..           :.|||
Yeast   263 TKKVTGAFLGTNVGTPLHRKLSKLAVLLFWIAVLFAIIVMASQKFDVDK-----------RVAIY 316

  Fly   295 YFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTN 359
                |:.:|::.||..|..|:|..:::|...|..:|.|||.|.|:|.||..:.||||||||||..
Yeast   317 ----AICVALSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQG 377

  Fly   360 QMSVSRMFI--------------FDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIK------- 403
            :|...:::|              |:..|||.|....|.....::...|:|.:. |..|
Yeast   378 KMLARQIWIPRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGIL-QNFKDRLYEKD 441

  Fly   404 ---AADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLN--------SFSV 457
               ..|.|..|:......:.|.:.:..::....::..|:.||.|:.|.|.|::        ..|.
Yeast   442 LPEDIDMDLFQKWLETATLANIATVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTGEKST 506

  Fly   458 NKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDR--KSMSSYCTPLKASRLGTGPKLFVKGAPEG 520
            |:|. :...::::...|.....:.|...||..|.  |.|||    :..:.......::.|||.|.
Yeast   507 NQSN-ENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSS----VYYNNHNETYNIYGKGAFES 566

  Fly   521 VLERCT--HARVGTTKVPLT----SALKAKILALTGQYGTGRDTLRCLALA--------VADSPM 571
            ::..|:  :.:.|....|||    ..::..:      |....:.||.|..|        |.|..:
Yeast   567 IISCCSSWYGKDGVKITPLTDCDVETIRKNV------YSLSNEGLRVLGFASKSFTKDQVNDDQL 625

  Fly   572 KPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAIC 636
            |....:...:      |.:|.|:|::|:.||||.|...::.:...|||.|.::|||...||:||.
Yeast   626 KNITSNRATA------ESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIA 684

  Fly   637 RRIGVFA------EDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMN 695
            :.:|:..      ..|.......:|.:||.||..|.........:.:|..||.|.:::|.|....
Yeast   685 QEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRK 749

  Fly   696 EISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQ 759
            :..|||||||||:|:||.|.:||||| :|:.|:|.|:::||:||||:||::||||||.:.:|:::
Yeast   750 KFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQK 814

  Fly   760 FIRYLISSNIGEVVSIFLTAALGLPE-------ALIPVQLLWVNLVTDGLPATALGFNPPDLDIM 817
            |:..|::.|:.:  :::|...|...:       .|.||::||:.:||...||..||......|:|
Yeast   815 FVLQLLAENVAQ--ALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSCFPAMGLGLEKAAPDLM 877

  Fly   818 EKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSY-WQLTHHLSCLGGGD 881
            ::||..::.|:.:..:.....|.|..:..:.: |:....::.....:|.: ...|::.||   .|
Yeast   878 DRPPHDSEVGIFTWEVIIDTFAYGIIMTGSCM-ASFTGSLYGINSGRLGHDCDGTYNSSC---RD 938

  Fly   882 EFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITMPP-------------WCNLWL 933
            .::           :.:.|.:.:....::.|...:...:|...|.|             |.|.:|
Yeast   939 VYR-----------SRSAAFATMTWCALILAWEVVDMRRSFFRMHPDTDSPVKEFFRSIWGNQFL 992

  Fly   934 IGSMALSFTLHFVILYVDVLS-TVFQVTPLSAEEWITVMKFSI 975
            ..|:...|...|.::|:.|:: .||...|:.| ||...:.|:|
Yeast   993 FWSIIFGFVSAFPVVYIPVINDKVFLHKPIGA-EWGLAIAFTI 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	289/1083 (27%)
ENA2	NP_010324.3	ATPase-IID_K-Na	11..1055	CDD:130586	289/1083 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I3248
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820