DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and ECA3

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_563860.1	Gene:	ECA3 / 837550	AraportID:	AT1G10130	Length:	998	Species:	Arabidopsis thaliana

Alignment Length:	998	Identity:	555/998 - (55%)
Similarity:	703/998 - (70%)	Gaps:	32/998 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            |||.::::|.:.|:|||.||.:||:..|:..:.:.||.|.||.|:....|:|||:||||||||||
plant     1 MEDAYARSVSEVLDFFGVDPTKGLSDSQVVHHSRLYGRNVLPEEKRTPFWKLVLKQFDDLLVKIL 65

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            ::|||:|||||| ...|...|||:||.||||||.|||.|||..|.|||.|:|.|:.|:..:..|:
plant    66 IVAAIVSFVLAL-ANGETGLTAFLEPFVILLILAANAAVGVITETNAEKALEELRAYQANIATVL 129

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |.....|  :.|.|:||||:|||:||.|||||:|:..:.|.|.|:||:||||||.||.|..|...
plant   130 RNGCFSI--LPATELVPGDIVEVTVGCKIPADLRMIEMSSNTFRVDQAILTGESCSVEKDVDCTL 192

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260
            ...||.|||||||||||:|.||:.|.||||.|.:||:|.|...|.:|::..|||::||||||..|
plant   193 TTNAVYQDKKNILFSGTDVVAGRGRAVVIGVGSNTAMGSIHDSMLQTDDEATPLKKKLDEFGSFL 257

  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            :|||:.|||.||.:|||||:||:||| :.||||:||||||||||||||||||||:||||||||::
plant   258 AKVIAGICVLVWVVNIGHFSDPSHGG-FFKGAIHYFKIAVALAVAAIPEGLPAVVTTCLALGTKK 321

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||:.||||||||||||||||:|||||||||||||.||||::.:....| :.....||.::|:||.
plant   322 MARLNAIVRSLPSVETLGCTTVICSDKTGTLTTNMMSVSKICVVQSAE-HGPMINEFTVSGTTYA 385

  Fly   391 PIGEVF-LNGQRIK-AADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEK-- 451
            |.|.|| .||.::. .|....|..|:....:||||.:.||..|.::||:||:||.||.|||||
plant   386 PEGTVFDSNGMQLDLPAQSPCLHHLAMCSSLCNDSILQYNPDKDSYEKIGESTEVALRVLAEKVG 450

  Fly   452 LNSFSVNKSGLD---RRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLF 513
            |..|....|.|:   :...|..|....|.::||.:.|||:||||.||..|:..:..      .:|
plant   451 LPGFDSMPSALNMLSKHERASYCNHYWENQFKKVYVLEFTRDRKMMSVLCSHKQMD------VMF 509

  Fly   514 VKGAPEGVLERCTH--ARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEM 576
            .|||||.::.||..  .....:.||||:|.:|::.:..  |..|.:||||||||....|.
plant   510 SKGAPESIIARCNKILCNGDGSVVPLTAAGRAELESRF--YSFGDETLRCLALAFKTVPH----- 567

  Fly   577 DLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGV 641
              |..|..|..|.:|||:|:||||||||:||.|:::.|..|||||||:|||||:|||::||:||.
plant   568 --GQQTISYDNENDLTFIGLVGMLDPPREEVRDAMLACMTAGIRVIVVTGDNKSTAESLCRKIGA 630

  Fly   642 FAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVN 706
            |....|.:|.||:..||:.|...:|..|:.|..|||||||.||..:||.||..||:.||||||||
plant   631 FDNLVDFSGMSYTASEFERLPAVQQTLALRRMTLFSRVEPSHKRMLVEALQKQNEVVAMTGDGVN 695

  Fly   707 DAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGE 771
            ||||||||:|||||||||||||||::||||||||:|||:||.||||||||.||||||:|||||||
plant   696 DAPALKKADIGIAMGSGTAVAKSASDMVLADDNFASIVAAVAEGRAIYNNTKQFIRYMISSNIGE 760

  Fly   772 VVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFR 836
            ||.||:.|.||:|:.|.||||||||||||||||||:|||..|.|:|:..|||..|.:::||||||
plant   761 VVCIFVAAVLGIPDTLAPVQLLWVNLVTDGLPATAIGFNKQDSDVMKAKPRKVGEAVVTGWLFFR 825

  Fly   837 YMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMAL 901
            |:.||.|||.|||....||||:||.||||:|.:|.:..:|......:   .|.||.|.|..|:|:
plant   826 YLVIGVYVGLATVAGFIWWFVYSDGGPKLTYSELMNFETCALRETTY---PCSIFEDRHPSTVAM 887

  Fly   902 SVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEE 966
            :|||.:||.||:|:|||||||:.:.|..||||:||:.|:..||.:||||..|:.:|.|||||..|
plant   888 TVLVVVEMFNALNNLSENQSLLVITPRSNLWLVGSIILTMLLHVLILYVHPLAVLFSVTPLSWAE 952

  Fly   967 WITVMKFSIPVVLLDETLKFVAR 989
            |..|:..|.||:::||.|||::|
plant   953 WTAVLYLSFPVIIIDELLKFLSR 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	551/992 (56%)
ECA3	NP_563860.1	Cation_ATPase_N	4..72	CDD:279080	33/67 (49%)
		ATPase-IIA1_Ca	53..975	CDD:273452	533/944 (56%)
		E1-E2_ATPase	92..336	CDD:278548	154/246 (63%)
		Cation_ATPase	416..524	CDD:289987	47/113 (42%)
		COG4087	<604..>707	CDD:226572	62/102 (61%)
		Cation_ATPase_C	776..973	CDD:279079	110/199 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	241	1.000	Domainoid score	I581
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7635
Inparanoid	1	1.050	1011	1.000	Inparanoid score	I39
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		oto3006
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	LDO	PTHR42861
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X745
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840