DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and atp2c2

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_001072524.1	Gene:	atp2c2 / 779979	XenbaseID:	XB-GENE-5873516	Length:	1017	Species:	Xenopus tropicalis

Alignment Length:	999	Identity:	333/999 - (33%)
Similarity:	509/999 - (50%)	Gaps:	163/999 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLAL 77
            :.:...|.|.||:...:...:.|:..||...:....||:..|.||.:.|:.:||.:|::|.:.
Frog   139 VKYLQVDVESGLSECSVLQRRIKHSWNEFQVDNTDPIWKKYLGQFTNPLILLLLGSALVSIIT-- 201

  Fly    78 FEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRA 142
             :|:|:.    |...|.:||::..|.|   ||..:|.::|.|.:..|.....:|..|.  |.:.|
Frog   202 -KEYEDA----VSITVAILIVVTVAFV---QEYRSEKSLEELNKLVPPECNCIRDGKQ--QHLLA 256

  Fly   143 KEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQDKKNI 207
            :|:||||:|.:||||::|||||:  |.:|.|.:|:|..|||:....|...::.:...: ....||
Frog   257 RELVPGDVVCLSVGDRVPADIRL--IETTDLLVDESSFTGETEPCSKTHGSVDEASGI-ATLSNI 318

  Fly   208 LFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS----KVISVIC 268
            :|.||.|..|:.:|:|||.|..:..|::...|...|..|||||:.:|..|:|||    .:|.:|.
Frog   319 VFMGTLVRYGRGKGLVIGVGEKSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLSLFSFGIIGLIM 383

  Fly   269 VAVWAINIGHFNDPAHGGSWIKG--AIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNA 331
            :      ||          |::|  .:..|.|.|:|||||||||||.|:|..||||..|||.|..
Frog   384 L------IG----------WLQGKPLLSMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMANKRV 432

  Fly   332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVF 396
            ||:.||.||||||.:|||||||||||.|:|:.:::...|.        |..|:||..||..|.|.
Frog   433 IVKKLPIVETLGCCNVICSDKTGTLTANEMTATKLVTSDG--------LHAEVTGVGYEGKGYVS 489

  Fly   397 LNGQRIKAADYDTLQELSTICI--------MCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLN 453
            |      ....:.:.|.|::.|        :.|::.|..|..      :|:.||.||:||..|:.
Frog   490 L------LPSNEEVHEFSSVSIGKLVEAGCIANNAVIQNNTL------MGQPTEGALVVLGMKMG 542

  Fly   454 SFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAP 518
            ..:|:.:.:.                |||  :.||.:::.|:..|    ..|.......|:|||.
Frog   543 LSNVSDNYIR----------------KKE--IPFSSEQRWMAVKC----IERHNKEEIYFMKGAF 585

  Fly   519 EGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTK 583
            |.|::.||........:|:|.  :.|.|.|..:...|...||.||||...        :||
Frog   586 EEVIQHCTMYNSSGRSLPVTP--QQKSLYLQEEKNMGMQGLRVLALASGS--------ELG---- 636

  Fly   584 FYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDT 648
                  .|||:|:||::||||..|.:::.....:|:.|.:||||...||:||.|.||:      :
Frog   637 ------KLTFLGLVGIIDPPRAGVSEAVQILLESGVSVKMITGDALETAQAIGRNIGL------S 689

  Fly   649 TG--KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPAL 711
            .|  |:.||.|.|.:..:...:.|.:..:|.|..|:||.||::.||....|..|||||||||.||
Frog   690 NGHLKAISGEELDQIDESTLSSIVTKVSVFYRTSPKHKLKIIKALQKTGAIVGMTGDGVNDAVAL 754

  Fly   712 KKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSI 775
            |.|:||:||| :||.|:|.||:|:|.||:||:|::|:|||:.|:.|:|.|:|:.:|::|..:..|
Frog   755 KSADIGVAMGKTGTDVSKEAADMILVDDDFSTIMNAIEEGKGIFYNIKNFVRFQLSTSISALSLI 819

  Fly   776 FLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAI 840
            .|:..:.||..|..:|:||:|::.||.||.:||..|.|.|.:::|||.|.|.::|..|..:.:.
Frog   820 TLSTVMNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDAIKQPPRNAKEAILSRALILKILL- 883

  Fly   841 GFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLV 905
                 :||:..:...|||..|.|                       |.|:  .|...||..:..|
Frog   884 -----SATIIISGTLFVFWKEIP-----------------------DGKV--TPRTTTMTFTCFV 918

  Fly   906 TIEMLNAMNSLSENQSLITMPPWCN--LW------LIGSMALSFTLHFVILYVDVLSTVFQVTPL 962
            ..:|.||:...|.|:::..:..:.|  .|      ::|.||        ::|:..|..||....|
Frog   919 FFDMFNALACRSLNKTIFEIGLFKNRMFWYSVLGSILGQMA--------VIYIPPLQKVFLTQNL 975

  Fly   963 SAEEWITVMKFSIPVVLLDETLKF 986
            .|.:.:.:...:..|.:..|.:||
Frog   976 HALDLLFLAGLASSVFVASELIKF 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	333/999 (33%)
atp2c2	NP_001072524.1	P-type_ATPase_SPCA	158..998	CDD:319779	327/977 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930