DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERCA and Atp2c2

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_081198.1	Gene:	Atp2c2 / 69047	MGIID:	1916297	Length:	944	Species:	Mus musculus

Alignment Length:	1006	Identity:	338/1006 - (33%)
Similarity:	512/1006 - (50%)	Gaps:	159/1006 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFV 74
            |:....|..|.:.||:...:...:..:|.||..|:..:.:|:..|:||.:.|:.:||.::::|
Mouse    61 EELARAFHVDLDSGLSEFAVAQRRLVHGWNEFVTDNAEPVWKKYLDQFRNPLILLLLGSSVVS-- 123

  Fly    75 LALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQK 139
             .|.:|:|:..:      :.|.:||. ..||..||..:|.::|.|.:..|.....:|..|  ::.
Mouse   124 -VLTKEYEDAVS------IALAVLIV-VTVGFIQEYRSEKSLEELTKLVPPECNCLRDGK--LRH 178

  Fly   140 VRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQD- 203
            :.|:::||||:|.:|:||:||||||:|.:  |.|.:|:|..||| |.....||:   |.|...|
Mouse   179 MLARDLVPGDIVSLSMGDRIPADIRLTEV--TDLLVDESSFTGE-VEPCGKTDS---PLADGGDL 237

  Fly   204 --KKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS----K 262
              ..|::|.||.|..||.:|||||||..:..|::...|...|..|||||:.:|:.|:||:    .
Mouse   238 STLSNVVFMGTLVQCGKGQGVVIGTGEQSQFGEVFKMMRAEETPKTPLQKSMDKLGKQLTIFSFG 302

  Fly   263 VISVICVAVWAINIGHFNDPAHGGSWIKGA--IYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            :|.::.:.                .|::|.  :..|.:.|:|||||||||||.|:...|.||..|
Mouse   303 IIGLLMLV----------------GWVQGKPFLSMFTVGVSLAVAAIPEGLPIVVMVTLVLGVLR 351

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||||..||:.||.||||||.:|||||||||||.|:|:.:::...|....        |::|..|.
Mouse   352 MAKKRVIVKKLPIVETLGCCNVICSDKTGTLTANEMTATQLVTSDGFHA--------EVSGVGYS 408

  Fly   391 PIGEVFL--NGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLN 453
            ..|.|.|  :.:.||..|..::.:|.....:.|::.|..|..      :|:.||.||:|||.|:|
Mouse   409 GEGTVCLLPSKEVIKGFDNVSVGKLVEAGCVANNAVIRKNAV------MGQPTEGALVVLAMKMN 467

  Fly   454 SFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPK------- 511
                              .|.|:..:.::..:.||.::|.|:..|          |||
Mouse   468 ------------------LGSIKDSYVRKKEIPFSSEQKWMAVRC----------GPKSEDGEDI 504

  Fly   512 LFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEM 576
            .|:|||.|.|:..|:....|...:|||...|:.......:.|    :|....||:|..|
Mouse   505 YFMKGAFEEVIHHCSMYNNGGIPLPLTPQQKSYCQQEEKKMG----SLGLRVLALASGP------ 559

  Fly   577 DLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGV 641
            :||          .|||:|:||::||||..|.:::.....:|:.|.::|||...||.||.|.||:
Mouse   560 ELG----------RLTFLGLVGIIDPPRAGVKEAVQVLSESGVSVKMVTGDALETALAIGRTIGL 614

  Fly   642 FAEDEDTTGKSYSGREFDDLSPTEQKAAVARSR---LFSRVEPQHKSKIVEFLQSMNEISAMTGD 703
            ..|..    |:.||.|.:.   |||.|..||.|   :|.|..|:||.||::.||....|.|||||
Mouse   615 CNEKL----KAMSGEEVEG---TEQGALAARVRQVSVFFRTSPKHKVKIIKALQESGAIVAMTGD 672

  Fly   704 GVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISS 767
            ||||:.|||.|:|||||| :||.|:|.||.|:|.||:||:|:||||||:.|:.|:|.|:|:.:|:
Mouse   673 GVNDSVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMSAVEEGKGIFYNIKNFVRFQLST 737

  Fly   768 NIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGW 832
            :|..:..|.|:....||..|..:|:||||::.||.||.:||..|.|.|.:.:|||...:.:::..
Mouse   738 SIAALSLITLSTVCNLPSPLNAMQILWVNIIMDGPPAQSLGVEPVDRDALRRPPRSVGDTILNRA 802

  Fly   833 LFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAM 897
            |..|.:.      :|.|......|:|..|.|.                   .|.     |.|...
Mouse   803 LILRVLM------SAAVIIGGTLFIFWREIPA-------------------NGT-----STPRTT 837

  Fly   898 TMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPL 962
            |||.:..|..::.||::..|:.:.:..:..:.|...:.|:..|......::|...|..|||...|
Mouse   838 TMAFTCFVFFDLFNALSCRSQTKLIFEIGFFRNRMFLYSVLGSLLGQLAVIYAPPLQKVFQTENL 902

  Fly   963 SAEEWITVMKFSIPVVLLDETL----KFVAR 989
            ||.:.:.:...:..|.:|.|.|    ||::|
Mouse   903 SALDLLLLTGLASSVFILSELLKLWEKFLSR 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	337/1004 (34%)
Atp2c2	NP_081198.1	ATPase-IIA2_Ca	54..929	CDD:130585	335/1000 (34%)
		Cation_ATPase_N	61..123	CDD:279080	16/61 (26%)
		Interaction with ORAI1. /evidence=ECO:0000250\|UniProtKB:O75185	69..93		6/23 (26%)
		E1-E2_ATPase	135..366	CDD:278548	97/255 (38%)
		Cation_ATPase	439..521	CDD:289987	30/115 (26%)
		COG4087	584..707	CDD:226572	61/129 (47%)
		Cation_ATPase_C	754..927	CDD:279079	52/202 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730